Choline-amino acid-derived bio-ionic liquids for solubility enhancement of zafirlukast

TitleCholine-amino acid-derived bio-ionic liquids for solubility enhancement of zafirlukast
Publication TypeJournal Article
Year of Publication2022
AuthorsGaikwad, N, Kudal, S, Avachat, AM
JournalAAPS Pharmscitech
Date PublishedMAY
Type of ArticleArticle
KeywordsAmino acids, choline chloride, Ionic liquid, solubility, zafirlukast

This study investigated the application of bio-ionic liquids (ILs) prepared from choline as cation and amino acid as anion for solubility enhancement of poorly water-soluble drug, Zafirlukast (ZFL). Herein, the solubility of ZFL in water and mixtures of water and ILs was assessed using UV spectroscopy at two temperature points 25 degrees C and 37 degrees C with increasing concentrations of IL. ZFL solubility was found to improve linearly with increasing concentration of [Ch][Pro] in water, representing 35- to 37-fold improvement in ZFL solubility at maximum concentration of [Ch][Pro] (1% w/v) compared to when only pure water was present. Also, the effect of IL on ZFL solubility was analyzed using NMR, DSC, and TGA. These results clearly suggest that ZFL solubility was increased by forming hydrogen bonds with selected [Ch][Pro] IL. Toxicity study of ILs was tested against gram-positive and gram-negative bacteria. Since IL solvent was found to increase the solubility of ZFL, this may serve as ``functional excipient solvent'' for solubility enhancement in its commercialized formulations.

Type of Journal (Indian or Foreign)


Impact Factor (IF)


Divison category: 
Polymer Science & Engineering
Web of Science (WoS)

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