Chiral pool approach for the synthesis of functionalized amino acids: synthesis of antiepileptic drug (R)-lacosamide
Title | Chiral pool approach for the synthesis of functionalized amino acids: synthesis of antiepileptic drug (R)-lacosamide |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Aratikatla, EK, Bhattacharya, AK |
Journal | Tetrahedron Letters |
Volume | 56 |
Issue | 42 |
Pagination | 5802–5803 |
Date Published | AUG |
Abstract | An efficient total synthesis of (R)-lacosamide 1 has been achieved from N-Boc-N,O-isopropylidene-l-serinol 2 which could easily be obtained from natural l-serine. Our synthesis of 1 starting from 2 using chiral pool strategy resulted in 54% overall yield. |
DOI | 10.1016/j.tetlet.2015.08.077 |
Funding Agency | Council of Scientific & Industrial Research (CSIR) - India |
Type of Journal (Indian or Foreign) | Foreign |
Impact Factor (IF) | 2.347 |
Divison category:
Organic Chemistry