Catalytic enantioselective 1,3-alkyl shift in alkyl aryl ethers: efficient synthesis of optically active 3,3 '-diaryloxindoles
| Title | Catalytic enantioselective 1,3-alkyl shift in alkyl aryl ethers: efficient synthesis of optically active 3,3 '-diaryloxindoles |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Gade, AB, Bagle, PN, Shinde, PS, Bhardwaj, V, Banerjee, S, Chande, A, Patil, NT |
| Journal | Angewandte Chemie-International Edition |
| Volume | 57 |
| Issue | 20 |
| Pagination | 5735-5739 |
| Date Published | MAY |
| Abstract | Reported is the first organocatalytic asymmetric 1,3-alkyl shift in alkyl aryl ethers for the synthesis of chiral 3,3'-diaryloxindoles using a chiral Bronsted acid catalyst. Preliminary results showed that each enantiomer of the 3,3'-diaryloxindole, and a racemic mixture, showed different antiproliferative activities against HeLa cell lines by using an MTT assay. |
| DOI | 10.1002/anie.201801650 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 11.994 |
Divison category:
Organic Chemistry
Physical and Materials Chemistry