Carbohydrate-based synthesis of the C13-C22 fragment of amphidinolide X
| Title | Carbohydrate-based synthesis of the C13-C22 fragment of amphidinolide X |
| Publication Type | Journal Article |
| Year of Publication | 2012 |
| Authors | Gurjar, MK, Yellol, GS, Mohapatra, DK |
| Journal | European Journal of Organic Chemistry |
| Issue | 9 |
| Pagination | 1753-1758 |
| Date Published | MAR |
| ISSN | 1434-193X |
| Keywords | Cytotoxicity, Macrolides, Mitsunobu inversion, Natural products, Wittig reactions |
| Abstract | A facile carbohydrate-based route was developed for the synthesis of the tetrahydrofuran (C13C22) fragment of amphidinolide X. Starting from L-sorbose, the key reactions followed include the stereoselective synthesis of a quaternary center at C1, BartonMcCombie deoxygenation at C2, Mitsunobu inversion at C3, and chain elongation by a Wittig reaction at C5. |
| DOI | 10.1002/ejoc.201101605 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.344 |
Divison category:
Organic Chemistry