Biocatalyst mediated regio- and stereo-selective hydroxylation and epoxidation of (Z)-alpha-santalol
| Title | Biocatalyst mediated regio- and stereo-selective hydroxylation and epoxidation of (Z)-alpha-santalol |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Daramwar, PP, Srivastava, PLal, Kolet, SP, Thulasiram, HV |
| Journal | Organic & Biomolecular Chemistry |
| Volume | 12 |
| Issue | 7 |
| Pagination | 1048-1051 |
| Date Published | JAN |
| Type of Article | Article |
| ISSN | 1477-0520 |
| Abstract | Biocatalyst mediated regio- and stereo-selective hydroxylation and epoxidation on (Z)-alpha-santalol were achieved for the first time, using a fungal strain Mucor piriformis. Four novel metabolites were characterized as 10,11-cis-beta-epoxy-alpha-santalol, 5 alpha-hydroxy-(Z)-alpha-santalol, 10,11-dihydroxy-alpha-santalol and 5 alpha-hydroxy-10,11-cis-beta-epoxy-alpha-santalol. Using Amano PS lipase from Burkholderia cepacia, alpha- and beta-isomers of 10,11-cis-epoxy-alpha-santalol were resolved efficiently. |
| DOI | 10.1039/c3ob42174k |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.559 |
Divison category:
Organic Chemistry