Beta, gamma-Bis-substituted PNA with configurational and conformational switch: preferred binding to cDNA/RNA and cell-uptake studies
| Title | Beta, gamma-Bis-substituted PNA with configurational and conformational switch: preferred binding to cDNA/RNA and cell-uptake studies |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Bose, T, Banerjee, A, Nahar, S, Maiti, S, Kumar, VA |
| Journal | Chemical Communications |
| Volume | 51 |
| Issue | 36 |
| Pagination | 7693-7696 |
| Date Published | MAR |
| Type of Article | Article |
| ISSN | 1359-7345 |
| Abstract | (S,S)- and (R,R)-beta,gamma-Bis-substituted PNAs were synthesized from the C-2 symmetric vicinal diamine system embedded in 1,4 dihydroxybutane and 1,4-dimethoxybutane scaffolds. (R,R)-beta,gamma-Bis-methoxymethyl-PNA derived from D-tartaric acid was found to be in the right configuration and conformation to be an excellent mimic of PNA, endowed with superior ability to enter into cells. |
| DOI | 10.1039/c5cc00891c |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 6.567 |
Divison category:
Organic Chemistry