Base mediated approach for the synthesis of deoxybenzoins using γ-aryl-β-ketoesters and benzoyl chlorides
| Title | Base mediated approach for the synthesis of deoxybenzoins using γ-aryl-β-ketoesters and benzoyl chlorides |
| Publication Type | Journal Article |
| Year of Publication | 2025 |
| Authors | Choudhary, SSingh, Darole, RS, Krishna, GRama, Senthilkumar, B |
| Journal | RSC Advances |
| Volume | 15 |
| Issue | 39 |
| Pagination | 32424-32430 |
| Date Published | SEP |
| Type of Article | Article |
| Abstract | This study introduces a one-pot, transition metal-free strategy for synthesizing deoxybenzoins, overcoming the challenges of conventional methods. The reaction involves dual acylation of gamma-aryl beta-keto esters using K2CO3 in dioxane at 90 degrees C, followed by a concerted transformation to form deoxybenzoin. The protocol operates under mild conditions, tolerates a broad range of substrates, and produces minimal by-products, making it a practical, scalable alternative for accessing pharmaceutically relevant deoxybenzoins. |
| DOI | 10.1039/d5ra05242d |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 4.6 |
Divison category:
Organic Chemistry
Database:
Web of Science (WoS)
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