Base-catalyzed mukaiyama-type aldol additions, a continued quest for stereoselectivity

TitleBase-catalyzed mukaiyama-type aldol additions, a continued quest for stereoselectivity
Publication TypeJournal Article
Year of Publication2013
AuthorsSutar, RL, Joshi, NN
JournalTetrahedron-Asymmetry
Volume24
Issue21-22
Pagination1345-1363
Date PublishedNOV
ISSN0957-4166
Abstract

Base-catalyzed reactions of silyl enolates with carbonyl compounds are an attractive variant of conventional directed aldol reactions. Over the past two decades, the reaction has gained prominence due to its inherent advantage for stereoselective manipulations. The present review provides a brief account of developments in this area. Various approaches are grouped together in order to provide the salient features of each conceptual development. It appears that the methods which generate nascent chiral enolates or cationic siliconium species have the biggest influence on the stereoselectivity. (C) 2013 Elsevier Ltd. All rights reserved.

DOI10.1016/j.tetasy.2013.09.012
Type of Journal (Indian or Foreign)Foreign
Impact Factor (IF)2.165
Divison category: 
Organic Chemistry