Attempted synthesis of the central 2,2-disubstituted pseudoindoxyl core of Austamide via a [Au]-catalyzed nitroalkyne cycloisomerization and intramolecular [3+2]-cycloaddition
Title | Attempted synthesis of the central 2,2-disubstituted pseudoindoxyl core of Austamide via a [Au]-catalyzed nitroalkyne cycloisomerization and intramolecular [3+2]-cycloaddition |
Publication Type | Journal Article |
Year of Publication | 2024 |
Authors | Halnor, SV, Ramana, CV |
Journal | Tetrahedron |
Volume | 167 |
Pagination | 134301 |
Date Published | NOV |
Type of Article | Article |
ISSN | 0040-4020 |
Keywords | Austamide, Gold catalysis, Intramolecular [3+2] cycloaddition, Nitroalkyne cycloisomerization |
Abstract | Herein, we describe an Au-catalyzed cycloisomerization process of a nitroalkyne that was projected to construct the central 2,2-disubstituted pseudoindoxyl core of the natural product Austamide. Our intended strategy for forging the pseudoindoxyl core is based on the nitroalkyne cycloisomerization followed by a subsequent intramolecular [3 + 2] cycloaddition. However, the [3 + 2] cycloaddition occurred in an undesired manner, ultimately leading to a complex hexacyclic scaffold. |
DOI | 10.1016/j.tet.2024.134301 |
Type of Journal (Indian or Foreign) | Foreign |
Impact Factor (IF) | 2.1 |
Divison category:
Organic Chemistry
Database:
Web of Science (WoS)
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