Attempted synthesis of the central 2,2-disubstituted pseudoindoxyl core of Austamide via a [Au]-catalyzed nitroalkyne cycloisomerization and intramolecular [3+2]-cycloaddition

TitleAttempted synthesis of the central 2,2-disubstituted pseudoindoxyl core of Austamide via a [Au]-catalyzed nitroalkyne cycloisomerization and intramolecular [3+2]-cycloaddition
Publication TypeJournal Article
Year of Publication2024
AuthorsHalnor, SV, Ramana, CV
JournalTetrahedron
Volume167
Pagination134301
Date PublishedNOV
Type of ArticleArticle
ISSN0040-4020
KeywordsAustamide, Gold catalysis, Intramolecular [3+2] cycloaddition, Nitroalkyne cycloisomerization
Abstract

Herein, we describe an Au-catalyzed cycloisomerization process of a nitroalkyne that was projected to construct the central 2,2-disubstituted pseudoindoxyl core of the natural product Austamide. Our intended strategy for forging the pseudoindoxyl core is based on the nitroalkyne cycloisomerization followed by a subsequent intramolecular [3 + 2] cycloaddition. However, the [3 + 2] cycloaddition occurred in an undesired manner, ultimately leading to a complex hexacyclic scaffold.

DOI10.1016/j.tet.2024.134301
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

2.1

Divison category: 
Organic Chemistry
Database: 
Web of Science (WoS)

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