Asymmetric synthesis of (R)-(-)-baclofen via asymmetric dihydroxylation
| Title | Asymmetric synthesis of (R)-(-)-baclofen via asymmetric dihydroxylation |
| Publication Type | Journal Article |
| Year of Publication | 2007 |
| Authors | Thakur, VV, Paraskar, AS, Sudalai, A |
| Journal | Indian Journal of Chemistry Section B-Organic Chemistry including Medicinal Chemistry |
| Volume | 46 |
| Issue | 2 |
| Pagination | 326-330 |
| Date Published | FEB |
| Type of Article | Article |
| ISSN | 0376-4699 |
| Keywords | asymmetric dihydroxylation, baclofen, cyclic sulfate, gamma-aminobutyric acid, Parkinsons' disease |
| Abstract | A short and efficient asymmetric synthesis of (R)-(-)-baclofen, a selective GABA(B) agonist has been described with an overall yield of 14% and 85% ee. The Os-catalyzed Sharpless asymmetric dihydroxylation of alpha,beta-unsaturated olefin constitutes the key step in introducing stereogenic centers into the molecule. |
| Type of Journal (Indian or Foreign) | Indian |
| Impact Factor (IF) | 0.471 |
Divison category:
Chemical Engineering & Process Development