Aryne insertion reactions leading to bioactive fused quinazolinones: diastereoselective total synthesis of cruciferane
|Title||Aryne insertion reactions leading to bioactive fused quinazolinones: diastereoselective total synthesis of cruciferane|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Vaidya, SD, Argade, NP|
Insertion reactions of an in situ generated arynes to a variety of suitably substituted 1,3-quinazolin-4-ones have been demonstrated for a new efficient one-step approach to a diverse range of fused quinazolinone architectures. The present protocol has been effectively utilized to accomplish the concise total synthesis of recently isolated bioactive natural products tryptanthrin, phaitanthrins A-C, and cruciferane.
|Type of Journal (Indian or Foreign)||Foreign|
|Impact Factor (IF)||6.324|