Antituberculosis agent diaportheone B: synthesis, absolute configuration assignment, and anti-TB activity of its analogues
| Title | Antituberculosis agent diaportheone B: synthesis, absolute configuration assignment, and anti-TB activity of its analogues |
| Publication Type | Journal Article |
| Year of Publication | 2012 |
| Authors | Swaroop, PSiva, Raut, GN, Gonnade, RG, Verma, P, Gokhale, RS, D. Reddy, S |
| Journal | Organic & Biomolecular Chemistry |
| Volume | 10 |
| Issue | 28 |
| Pagination | 5385-5394 |
| Date Published | MAY |
| ISSN | 1477-0520 |
| Abstract | First synthesis of diaportheone B, an antituberculosis agent isolated from endophytic fungus Diaporthe sp. P133 is reported using two complementary routes, a one step and a three-step sequence. The absolute configuration of diaportheone B was determined by using X-ray crystal structure analysis of its dibromo derivative. In addition, we have prepared several close analogues of diaportheone B and determined their anti-TB potential using Alamar-blue assay (H(37)Rv). |
| DOI | 10.1039/c2ob25831e |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.568 |
Divison category:
Center for Material Characterization (CMC)
Organic Chemistry