Antisolvent based ultrasound-assisted batch and continuous flow precipitation of metformin hydrochloride particles

TitleAntisolvent based ultrasound-assisted batch and continuous flow precipitation of metformin hydrochloride particles
Publication TypeJournal Article
Year of Publication2021
AuthorsPal, S, Nikam, AV, Kulkarni, AA
JournalJournal of Flow Chemistry
Volume11
Issue2
Pagination181-192
Date PublishedJUN
Type of ArticleArticle
ISSN2062-249X
KeywordsContinuous antisolvent precipitation, Jet-reactor, Metformin, supersaturation, Ultrasound
Abstract

Small sized particles of the antidiabetic drug metformin hydrochloride (MET.HCl) were produced by antisolvent based precipitation using an ultrasound assisted inverted jet reactor (IJR). This novel approach was implemented as a small passive mixer in which intensified turbulent mixing of the solution and the antisolvent occurred under controlled conditions. The optimized conditions for antisolvent precipitation (ASP) were investigated by studying the effect of solute concentration, antisolvent to solvent ratio and antisolvent temperature in batch systems. The optimized batch precipitation conditions were successfully translated into continuous flow process for the ultrasound assisted inverted jet reactor. The ability of the proposed clogging free inverted jet reactor approach can provide a scaled up alternative pathway to micro and millifluidic devices for manufacturing of small sized API particles, such as, MET.HCl for the formulations and encapsulations on an industrial scale.

DOI10.1007/s41981-020-00137-y, Early Access Date = JAN 2021
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)2.786
Divison category: 
Chemical Engineering & Process Development

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