Antimycobacterial labdane diterpenes from leucas stelligera
| Title | Antimycobacterial labdane diterpenes from leucas stelligera |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Kulkarni, RR, Shurpali, K, Puranik, VG, Sarkar, D, Joshi, SP |
| Journal | Journal of Natural Products |
| Volume | 76 |
| Issue | 10 |
| Pagination | 1836-1841 |
| Date Published | OCT |
| ISSN | 0163-3864 |
| Abstract | Phytochemical investigation of the acetone extract of the aerial parts of Leucas stelligera afforded four new compounds (1-4) belonging to the labdane diterpene series as well as two known flavones, velutin (5) and chrysoeriol (6). Structure elucidation of the new compounds was carried out using ID and 2D NMR spectroscopic data and single-crystal X-ray crystallography of compound 1. Compounds 1-4 exhibited selective antimycobacterial activity against Mycobacterium tuberculosis with IC50 values in the range 5.02-9.80 mu g/mL. |
| DOI | 10.1021/np400002p |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 3.947 |
Divison category:
Biochemical Sciences
Center for Material Characterization (CMC)
Organic Chemistry