Antibiotic natural product hunanamycin A: Lead identification towards anti-Salmonella agents
| Title | Antibiotic natural product hunanamycin A: Lead identification towards anti-Salmonella agents |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Shingare, RD, MacMillan, JB, D. Reddy, S |
| Journal | European Journal of Medicinal Chemistry |
| Volume | 236 |
| Pagination | 114245 |
| Date Published | JUN |
| Type of Article | Article |
| ISSN | 0223-5234 |
| Keywords | Antibiotic natural product, Hunanamycin A, Riboflavin synthase, Salmonella, Structure activity relationship |
| Abstract | Design and synthesis of library of compounds around the antibiotic natural product hunanamycin A scaffold and their biological evaluation are disclosed here. These efforts resulted in identification of a lead compound 36, which is a structurally simplified analogue of original hunanamycin A with impressive activity against Salmonella enterica and possesses other druggable properties. In addition, no acute oral toxicity was observed for compound 36 in Swiss albino mice dosed up to 2 g/kg. It has the potential to be developed for the treatment of food infections caused by Salmonella. (c) 2022 Published by Elsevier Masson SAS. |
| DOI | 10.1016/j.ejmech.2022.114245 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 7.088 |
Divison category:
Organic Chemistry
Database:
Web of Science (WoS)