Anti-cancer therapeutic potential of quinazoline based small molecules via global upregulation of miRNAs

TitleAnti-cancer therapeutic potential of quinazoline based small molecules via global upregulation of miRNAs
Publication TypeJournal Article
Year of Publication2014
AuthorsNahar, S, Bose, D, Panja, SKumar, Saha, S, Maiti, S
JournalChemical Communications
Volume50
Issue35
Pagination4639-4642
Date PublishedMAR
Type of ArticleArticle
ISSN1359-7345
Abstract

Three quinazoline based small molecules showed global upregulation of miRNA expression with a selective enrichment of tumor suppressor miRNAs. The target genes of the upregulated miRNAs were predicted to be enriched for apoptotic pathways. Apoptotic induction following treatment with quinazoline compounds was confirmed by in cellulo studies. Thus, these small molecules having the core structural moiety (2,4-diphenyl-quinazoline) can be used as scaffolds to design activators of miRNA expression paving the way for novel anti-cancer drugs.

DOI10.1039/c3cc49337g
Type of Journal (Indian or Foreign)Foreign
Impact Factor (IF)6.567
Divison category: 
Biochemical Sciences