Amino functionalized novel cholic acid derivatives induce HIV-1 replication and syncytia formation in T cells
| Title | Amino functionalized novel cholic acid derivatives induce HIV-1 replication and syncytia formation in T cells |
| Publication Type | Journal Article |
| Year of Publication | 2006 |
| Authors | Salunke, DB, Ravi, DS, Pore, VS, Mitra, D, Hazra, BG |
| Journal | Journal of Medicinal Chemistry |
| Volume | 49 |
| Issue | 8 |
| Pagination | 2652-2655 |
| Date Published | APR |
| Type of Article | Article |
| ISSN | 0022-2623 |
| Abstract | Synthesis of C-11 azido/amino functionalized cholic acid derivatives has been achieved in excellent yields. Contrary to the previous prediction of analogous compounds to be HIV-1 protease inhibitors, in the present study these novel cholic acid derivatives induced host cell fusion during the progress of HIV-1 infection and produced multinucleated giant cells. This is the first report of syncytia induction and enhancement of viral replication in HIV-1 infected T cells by cholic acid derivatives. |
| DOI | 10.1021/jm051114u |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 5.589 |
Divison category:
Organic Chemistry