Active pharmaceutical ingredient (api) from an estuarine fungus, microdochium nivale (Fr.)

TitleActive pharmaceutical ingredient (api) from an estuarine fungus, microdochium nivale (Fr.)
Publication TypeJournal Article
Year of Publication2011
AuthorsBhosale, SH, Patil, KB, Parameswaran, PS, Naik, CG, Jagtap, TG
JournalJournal of Environmental Biology
Date PublishedSEP
Keywordsantifungal, Cyclosporine A, Estuarine environment, Microdochium nivale

Various marine habitats sustain variety of bio-sources of ecological and biotech potentials. Pharmaceutical potential compound Cyclosporine A was reported from marine fungus Microdochium nivale associated with Porteresia coarctata, a marine salt marsh grass from mangrove environment distributed along the Central West Coast (CWC) of India. This study involves association of M. nivale with P. coarctata plant, fermentation conditions, purification of Cyclosporine A, chemical characterization etc. Its antifungal inhibition and MIC (Minimum inhibitory concentration) against Aspergillus strains (A. niger, A. japonicus, A. fresenii), yeasts and dermatophytes (Candida sp., Cryptococcus neoformans, Trichophyton mentagrophytes, T tonsurans, T violaceum, Microsporium gypsum and Fusarium sp.) were evaluated. However, the MIC against A. japonicus, C. neoformans, Candida sp. and T. tonsurans were confirmed to be as low as 12.5-25 mg disc(-1). The antifungal properties of Cyclosporine A against Aspergillus species, yeast and dermatophytes revealed that Cyclosporine A would be a potential compound for life threatening diseases caused by above fungi in both human and animals. Furthermore, we have reported herewith another source of Cyclosporin A derived from filamentous fungus, M. nivale. occurring in marine environment.

Type of Journal (Indian or Foreign)Indian
Impact Factor (IF)0.97
Divison category: 
Biochemical Sciences