Cu(ii)/I2 mediated synthesis of α-keto esters via C(sp2)-C(sp) bond cleavage of 1,2-alkynediones followed by C-O bond formation
| Title | Cu(ii)/I2 mediated synthesis of α-keto esters via C(sp2)-C(sp) bond cleavage of 1,2-alkynediones followed by C-O bond formation |
| Publication Type | Journal Article |
| Year of Publication | 2026 |
| Authors | Naveed, A, Sawant, SD |
| Journal | New Journal of Chemistry |
| Volume | 50 |
| Issue | 12 |
| Pagination | 5076-5080 |
| Date Published | MAR |
| Type of Article | Article |
| ISSN | 1144-0546 |
| Abstract | Herein, we disclose an efficient method for the synthesis of alpha-keto esters through a copper(ii)/iodine-mediated reaction. The transformation involves the selective cleavage of the C(sp2)-C(sp) bond of 1,2-alkynediones, which is subsequently followed by C-O bond formation with alcohols. This protocol offers a broad substrate scope, accommodating a wide range of substrates to furnish the desired alpha-keto esters in good yields. |
| DOI | 10.1039/d6nj00240d |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2.5 |
Divison category:
Organic Chemistry
Database:
Web of Science (WoS)
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