Silica-supported orthophosphoric acid (H3PO4·SiO2) as an environmentally friendly, heterogeneous catalyst for one-pot synthesis of 4-substituted 1,5-benzodiazepines
| Title | Silica-supported orthophosphoric acid (H3PO4·SiO2) as an environmentally friendly, heterogeneous catalyst for one-pot synthesis of 4-substituted 1,5-benzodiazepines |
| Publication Type | Journal Article |
| Year of Publication | 2025 |
| Authors | Kattimani, MS, Khyadage, PH, Mitragotri, SD, Kulkarni, MA, Wadgaonkar, PP |
| Journal | Chemistry of Heterocyclic Compounds |
| Volume | 61 |
| Issue | 9-10 |
| Pagination | 485-490 |
| Date Published | OCT |
| Type of Article | Article |
| ISSN | 0009-3122 |
| Keywords | 4-substituted 1, 5-benzodiazepine, aldehydes, dimedone, o-Phenylenediamine, silica-supported orthophosphoric acid |
| Abstract | An efficient, environmentally friendly protocol was developed for the synthesis of 4-substituted 1,5-benzodiazepines via a one-pot three-component reaction. o-Phenylenediamines, dimedone, and aldehydes were reacted in the presence of silica-supported orthophosphoric acid (H3PO4 & centerdot;SiO2) as an environmentally friendly, heterogeneous catalyst at 70 degrees C to produce 4-substituted 1,5-benzodiazepines. High to excellent yields, metal-free, environmentally friendly, reusable catalyst, and faster reactivity are the notable features of the developed protocol. |
| DOI | 10.1007/s10593-026-03447-6 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 1.2 |
Divison category:
Polymer Science & Engineering
Database:
Web of Science (WoS)
Add new comment