H5IO6, as an efficient reagent for the aromatization of tetrahydro-β-carbolines: total synthesis of norharman, harmane, harmine, kumujian-C, and orthoscuticellines B
| Title | H5IO6, as an efficient reagent for the aromatization of tetrahydro-β-carbolines: total synthesis of norharman, harmane, harmine, kumujian-C, and orthoscuticellines B |
| Publication Type | Journal Article |
| Year of Publication | 2026 |
| Authors | Sabane, JK, Gaikwad, SV, Gajbhiye, JM, Kumar, P |
| Journal | ChemistrySelect |
| Volume | 11 |
| Issue | 10 |
| Pagination | e04252 |
| Date Published | MAR |
| Type of Article | Article |
| ISSN | 2365-6549 |
| Keywords | aromatization, beta-carboline, H5IO6, Harmine, orthoscuticellines, Oxidative |
| Abstract | A new method is reported for the synthesis of beta-carbolines and their derivatives using H5IO6 in DMSO solvent. The method is mild and efficient for oxidative decarboxylation and aromatization of tetrahydro beta-carbolines (TH beta C), resulting in good to excellent yields (70% to 88%) of beta-carbolines. This protocol has further been utilized for the synthesis of beta-carbolines based natural products, for examples, norharmane, harmane, harmine, Kumujian-C, and Orthoscuticellines A and B. |
| DOI | 10.1002/slct.202504252 |
| Type of Journal (Indian or Foreign) | Foreign |
| Impact Factor (IF) | 2 |
Divison category:
Organic Chemistry
Database:
Web of Science (WoS)
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