<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mohapatra, Debendra K.</style></author><author><style face="normal" font="default" size="100%">Pramanik, Chintnoy</style></author><author><style face="normal" font="default" size="100%">Chorghade, Mukund S.</style></author><author><style face="normal" font="default" size="100%">Gurjar, Mukund K.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Short and efficient synthetic strategy for the total syntheses of (S)-(+)- and (R)-(-)-Plakolide A</style></title><secondary-title><style face="normal" font="default" size="100%">European Journal of Organic Chemistry</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cross-coupling</style></keyword><keyword><style  face="normal" font="default" size="100%">epoxidation</style></keyword><keyword><style  face="normal" font="default" size="100%">inhibitors</style></keyword><keyword><style  face="normal" font="default" size="100%">olefination</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2007</style></year><pub-dates><date><style  face="normal" font="default" size="100%">OCT</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">30</style></number><publisher><style face="normal" font="default" size="100%">WILEY-V C H VERLAG GMBH</style></publisher><pub-location><style face="normal" font="default" size="100%">PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY</style></pub-location><pages><style face="normal" font="default" size="100%">5059-5063</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Concise and efficient total syntheses of anticancer agents (S)(+)-Plakolide A and (R)-(-)-Plakolide A were accomplished in eight steps and an overall yield of 39 % starting from geraniol. The key steps in our strategy are Sharpless asymmetric epoxidation, double elimination, and Stille coupling reactions.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">30</style></issue><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">Foreign</style></custom3><custom4><style face="normal" font="default" size="100%">3.068</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bande, Omprakash P.</style></author><author><style face="normal" font="default" size="100%">Jadhav, Vrushali H.</style></author><author><style face="normal" font="default" size="100%">Puranik, Vedavati G.</style></author><author><style face="normal" font="default" size="100%">Dhavale, Dilip D.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Highly diastereoselective 1,3-dipolar cycloaddition of a D-galactose-derived nitrone with dimethyl maleate: synthesis of polyhydroxylated perhydroazaazulenes</style></title><secondary-title><style face="normal" font="default" size="100%">Synlett</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">1</style></keyword><keyword><style  face="normal" font="default" size="100%">3-dipolar nitrone olefin cycloaddition (DNOC)</style></keyword><keyword><style  face="normal" font="default" size="100%">diastereoselectivity</style></keyword><keyword><style  face="normal" font="default" size="100%">Iminosugars</style></keyword><keyword><style  face="normal" font="default" size="100%">inhibitors</style></keyword><keyword><style  face="normal" font="default" size="100%">nitrone</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2009</style></year><pub-dates><date><style  face="normal" font="default" size="100%">JUL</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">12</style></number><publisher><style face="normal" font="default" size="100%">GEORG THIEME VERLAG KG</style></publisher><pub-location><style face="normal" font="default" size="100%">RUDIGERSTR 14, D-70469 STUTTGART, GERMANY</style></pub-location><pages><style face="normal" font="default" size="100%">1959-1963</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;An intermolecular 1,3-dipolar cycloaddition of a D-galactose-derived nitrone with dimethyl maleate was found to be perfectly diastereoselective at the nitrone carbon to give exclusive formation of isoxazolidine. The N-O bond reductive cleavage in isoxazolidine followed by lactam reduction afforded a pyrrolidine ring skeleton with sugar appendage that on acetonide cleavage and reductive amino-cyclization gave hitherto unknown hydroxymethyl-substituted hexa- and pentahydroxy perhydroazaazulenes.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">12</style></issue><custom3><style face="normal" font="default" size="100%">Foreign</style></custom3><custom4><style face="normal" font="default" size="100%">2.447</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bose, Debojit</style></author><author><style face="normal" font="default" size="100%">Jayaraj, Gopal Gunanathan</style></author><author><style face="normal" font="default" size="100%">Suryawanshi, Hemant</style></author><author><style face="normal" font="default" size="100%">Agarwala, Prachi</style></author><author><style face="normal" font="default" size="100%">Pore, Subrata Kumar</style></author><author><style face="normal" font="default" size="100%">Banerjee, Rajkumar</style></author><author><style face="normal" font="default" size="100%">Maiti, Souvik</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Tuberculosis drug streptomycin as a potential cancer therapeutic: inhibition of miR-21 function by directly targeting its precursor</style></title><secondary-title><style face="normal" font="default" size="100%">Angewandte Chemie-International Edition</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Apoptosis</style></keyword><keyword><style  face="normal" font="default" size="100%">drug discovery</style></keyword><keyword><style  face="normal" font="default" size="100%">Gene expression</style></keyword><keyword><style  face="normal" font="default" size="100%">inhibitors</style></keyword><keyword><style  face="normal" font="default" size="100%">RNA</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2012</style></year><pub-dates><date><style  face="normal" font="default" size="100%">DEC</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">4</style></number><publisher><style face="normal" font="default" size="100%">WILEY-BLACKWELL</style></publisher><pub-location><style face="normal" font="default" size="100%">COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA</style></pub-location><volume><style face="normal" font="default" size="100%">51</style></volume><pages><style face="normal" font="default" size="100%">1019-1023</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">&lt;p&gt;Foreign&lt;/p&gt;</style></custom3><custom4><style face="normal" font="default" size="100%">13.734</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kumar, Asheesh</style></author><author><style face="normal" font="default" size="100%">Sakpal, Tushar</style></author><author><style face="normal" font="default" size="100%">Kumar, Rajnish</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Influence of low-dosage hydrate inhibitors on methane clathrate hydrate formation and dissociation kinetics</style></title><secondary-title><style face="normal" font="default" size="100%">Energy Technology</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">gas uptake</style></keyword><keyword><style  face="normal" font="default" size="100%">hydrates</style></keyword><keyword><style  face="normal" font="default" size="100%">inhibitors</style></keyword><keyword><style  face="normal" font="default" size="100%">kinetics</style></keyword><keyword><style  face="normal" font="default" size="100%">thermal stimulation</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">JUL</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">7, SI</style></number><publisher><style face="normal" font="default" size="100%">WILEY-V C H VERLAG GMBH</style></publisher><pub-location><style face="normal" font="default" size="100%">BOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY</style></pub-location><volume><style face="normal" font="default" size="100%">3</style></volume><pages><style face="normal" font="default" size="100%">717-725</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;This work investigates the effect of low-dosage hydrate inhibitors (LDHIs) on methane hydrate formation and dissociation. The hydrate inhibitors used in this study were the sodium salt of polyacrylic acid, a polysaccharide chitosan, and the linear sulfated polysaccharide i-carrageenan; the inhibiting behavior of these additives were compared with that of the commonly used hydrate inhibitor polyvinylpyrrolidone for methane hydrate formation. A LDHI concentration of 1wt% was found to increase the induction time relative to that at a LDHI concentration of 0.1wt%. Chitosan was found to be better than the others in reducing nucleation and the growth rate of the hydrate at a concentration of 1wt%. At a lower concentration of 0.1wt%, nucleation inhibition was minimal, however, growth inhibition was significant. The effect of these inhibitors on the decomposition rate of the hydrate was also studied, and the decomposition kinetics at a constant driving force in excess of three-phase equilibrium is reported.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">7</style></issue><custom3><style face="normal" font="default" size="100%">&lt;p&gt;Foreign&lt;/p&gt;</style></custom3><custom4><style face="normal" font="default" size="100%">2.483</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sinha, N.</style></author></authors><secondary-authors><author><style face="normal" font="default" size="100%">Chowdhury, S.</style></author></secondary-authors><tertiary-authors><author><style face="normal" font="default" size="100%">Sarkar, R. R.</style></author></tertiary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Deciphering structural stability and binding mechanisms of potential antagonists with smoothened protein</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Biomolecular Structure and Dynamics</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">inhibitors</style></keyword><keyword><style  face="normal" font="default" size="100%">Pi–Pi Interaction</style></keyword><keyword><style  face="normal" font="default" size="100%">Smoothened Protein</style></keyword><keyword><style  face="normal" font="default" size="100%">Structural stability</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">SEP</style></date></pub-dates></dates><pages><style face="normal" font="default" size="100%">1-21</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Identification of new potential inhibitors against Hedgehog pathway activator protein Smoothened (SMO) is considered to be of higher importance to improvise the future cancer therapeutics. Different SMO inhibitors/drugs (e.g. Cyclopamine, Vismodegib, Taladegib) used till date are found to be associated with several drug-related resistivity and toxicity. To explore the ability of new drug/inhibitor molecules, which can show better/similar binding and dynamic stability as compared to known inhibitors, virtual screening against SMO is performed followed by the comparative docking and molecular dynamic studies. ‘ZINC12368305’ is found to be the best molecule among the entire data-set, as it shows the highest binding affinity and stable conformations. Here, an integrative approach using Dynamic Graph Theory is introduced to gain the molecular insights of the structural integrity of these protein complexes at the residue level by analyzing the corresponding Protein Contact Networks along the Molecular Dynamics trajectories. The study further focuses to understand the detailed binding mechanisms of available inhibitor/drug molecules along with the newly predicted molecule. It is observed that a unique big cluster of low fluctuating residues at the vicinity of the drug binding pocket of the SMO in ZINC12368305-bound complex is present and driving it toward a more stable region. A close inspection on this site reveals the presence of a stable Pi–Pi interaction between the pyrazole group-associated phenanthrene ring of ZINC12368305 and aromatic ring of Phe484 of SMO, which could be the potential factor of ZINC12368305 to create a more stable complex with SMO as compared to the other inhibitors.</style></abstract><work-type><style face="normal" font="default" size="100%">Article in Press</style></work-type><custom3><style face="normal" font="default" size="100%">Foreign</style></custom3><custom4><style face="normal" font="default" size="100%">2.3</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sunny, Lisni P.</style></author><author><style face="normal" font="default" size="100%">Srikanth, Priya</style></author><author><style face="normal" font="default" size="100%">Sunitha, Anju Kunhiraman</style></author><author><style face="normal" font="default" size="100%">Tembulkar, Niyoti</style></author><author><style face="normal" font="default" size="100%">Abraham, Jancy Nixon</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Tryptophan-cardanol fluorescent nanoparticles inhibit alpha-synuclein aggregation and disrupt amyloid fibrils</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Peptide Science</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">alpha-synuclein</style></keyword><keyword><style  face="normal" font="default" size="100%">amyloid fibrils</style></keyword><keyword><style  face="normal" font="default" size="100%">Cardanol</style></keyword><keyword><style  face="normal" font="default" size="100%">inhibitors</style></keyword><keyword><style  face="normal" font="default" size="100%">Tryptophan</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">APR</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">28</style></volume><pages><style face="normal" font="default" size="100%">e3374</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;
	Protein misfolding and aggregation play a vital role in several human diseases such as Parkinson's, Alzheimer's, and prion diseases. The development of nanoparticles that modulate aggregation could be potential drug candidates for these neurodegenerative disorders. Parkinson's disease pathogenesis is closely associated with the accumulation of alpha-synuclein oligomers and fibrils in the substantia nigra of the brain. This report discusses the interactions of novel tryptophan-cardanol nanoparticles with alpha-synuclein protein monomers and fibrils. These nanoparticles could effectively disrupt alpha-synuclein fibrils and inhibit fibril formation at low concentrations such as 5 mu M. The tryptophan-cardanol nanoparticles inhibit fibril formation from unstructured protein resulting in spherical nanostructures. These nanoparticles could also disassemble amyloid fibrils; the complete disappearance of fibrils was evident after 48 h of incubation with tryptophan-cardanol. The transmission electron microscopy (TEM) micrographs after the incubation did not show any remnants of the peptide aggregates or oligomers. The thioflavin T fluorescence after the disassembly was diminished compared with that of fibrils also supports the inhibitory effect of the nanoparticles. Also, these nanoparticles did not reduce the viability of the SH-SY5Y cells. These findings suggest that the tryptophan-cardanol nanoparticles showed sufficiently high inhibitory activity and may have therapeutic potential for synucleinopathies.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">&lt;p&gt;
	Foreign&lt;/p&gt;
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	2.408&lt;/p&gt;
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