<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Pandey, SK</style></author><author><style face="normal" font="default" size="100%">Kumar, P</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Stereoselective syntheses of (+)-alpha- and (-)-beta-conhydrine from L-aspartic acid</style></title><secondary-title><style face="normal" font="default" size="100%">Tetrahedron Letters</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alkylation</style></keyword><keyword><style  face="normal" font="default" size="100%">conhydrine</style></keyword><keyword><style  face="normal" font="default" size="100%">Grignard reaction</style></keyword><keyword><style  face="normal" font="default" size="100%">Piperidine alkaloids</style></keyword><keyword><style  face="normal" font="default" size="100%">stereoselectivity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2005</style></year><pub-dates><date><style  face="normal" font="default" size="100%">JUN</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">23</style></number><publisher><style face="normal" font="default" size="100%">PERGAMON-ELSEVIER SCIENCE LTD</style></publisher><pub-location><style face="normal" font="default" size="100%">THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND</style></pub-location><volume><style face="normal" font="default" size="100%">46</style></volume><pages><style face="normal" font="default" size="100%">4091-4093</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;An efficient synthesis of (+)-alpha-conhydrine 1 and (-)-beta-conhydrine 2 has been achieved by. diastereo selective alkylation of an amino aldehyde derivative 7 with ethylmagnesium bromide or diethylzinc. (c) 2005 Elsevier Ltd. All rights reserved.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">23</style></issue><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">&lt;p&gt;Foreign&lt;/p&gt;</style></custom3><custom4><style face="normal" font="default" size="100%">2.347</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kale, Ajaykumar S.</style></author><author><style face="normal" font="default" size="100%">Sakle, Prathmesh S.</style></author><author><style face="normal" font="default" size="100%">Gumaste, Vikas K.</style></author><author><style face="normal" font="default" size="100%">Deshmukh, Abdul Rakeeb A. S.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">4-Formylazetidin-2-one as a useful building block for the formal synthesis of xylo-(2S,3R,4R)-phytosphingosine and threo-(2S,3S)-sphingosine</style></title><secondary-title><style face="normal" font="default" size="100%">Synthesis-Stuttgart </style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">azetidin-2-one</style></keyword><keyword><style  face="normal" font="default" size="100%">beta-lactam</style></keyword><keyword><style  face="normal" font="default" size="100%">Grignard reaction</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytosphingosine</style></keyword><keyword><style  face="normal" font="default" size="100%">Sphingosine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2007</style></year><pub-dates><date><style  face="normal" font="default" size="100%">SEP</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">17</style></number><publisher><style face="normal" font="default" size="100%">GEORG THIEME VERLAG KG</style></publisher><pub-location><style face="normal" font="default" size="100%">RUDIGERSTR 14, D-70469 STUTTGART, GERMANY</style></pub-location><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">2631-2636</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Stereoselective formal synthesis of xylo-(2S,3R,4R)-phytosphingosine and threo-(2S,3S)-sphingosine is described starting from an enantiopure formyl-substituted P-lactam. Grignard reaction of the N-Boc-protected-beta-lactam carbonyl group, followed by further transformations, provides a common intermediate for xylo-(2S,3R,4R)-phytosphingosine and threo-(2S,3S)-sphingosine.&lt;/p&gt;</style></abstract><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">&lt;p&gt;Foreign&lt;/p&gt;</style></custom3><custom4><style face="normal" font="default" size="100%">2.652</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Pandey, Satyendra Kumar</style></author><author><style face="normal" font="default" size="100%">Kumar, Pradeep</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Efficient total synthesis of (-)-(3S,6R)-3,6-dihydroxy-10-methylundecanoic acid</style></title><secondary-title><style face="normal" font="default" size="100%">European Journal of Organic Chemistry</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">cyclic sulfate</style></keyword><keyword><style  face="normal" font="default" size="100%">Dihydroxylation</style></keyword><keyword><style  face="normal" font="default" size="100%">Grignard reaction</style></keyword><keyword><style  face="normal" font="default" size="100%">hydroboration-oxidation</style></keyword><keyword><style  face="normal" font="default" size="100%">Jacobsen's hydrolytic kinetic resolution (HKR)</style></keyword><keyword><style  face="normal" font="default" size="100%">regio selectivity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2007</style></year><pub-dates><date><style  face="normal" font="default" size="100%">JAN</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">2</style></number><publisher><style face="normal" font="default" size="100%">WILEY-V C H VERLAG GMBH</style></publisher><pub-location><style face="normal" font="default" size="100%">PO BOX 10 11 61, D-69451 WEINHEIM, GERMANY</style></pub-location><pages><style face="normal" font="default" size="100%">369-373</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;An efficient enantioselective synthesis of (-)-(3S,6R)-3,6-dihydroxy-10-methylundecanoic acid (1) from epichlorohydrin is described. The key steps include Jacobsen's HKR, Sharpless asymmetric dihydroxylation, regioselective opening of epoxide and cyclic sulfate. ((c) Wiley-VCH Verlag GmbH &amp;amp; Co. KGaA, 69451 Weinheim, Germany, 2007).&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">Foreign</style></custom3><custom4><style face="normal" font="default" size="100%">3.068</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Chavan, Subhash P.</style></author><author><style face="normal" font="default" size="100%">Khobragade, Dushant A.</style></author><author><style face="normal" font="default" size="100%">Thakkar, Mahesh</style></author><author><style face="normal" font="default" size="100%">Kalkote, Uttam R.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Practical synthesis of (+/-)-venlafaxine</style></title><secondary-title><style face="normal" font="default" size="100%">Synthetic Communications</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antidepressant</style></keyword><keyword><style  face="normal" font="default" size="100%">Grignard reaction</style></keyword><keyword><style  face="normal" font="default" size="100%">Michael addition</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2007</style></year><pub-dates><date><style  face="normal" font="default" size="100%">NOV</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">22-24</style></number><publisher><style face="normal" font="default" size="100%">TAYLOR &amp; FRANCIS INC</style></publisher><pub-location><style face="normal" font="default" size="100%">325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA</style></pub-location><volume><style face="normal" font="default" size="100%">37</style></volume><pages><style face="normal" font="default" size="100%">3901-3906</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;A practical total synthesis of antidepressant (+/-)-venlafaxine is disclosed.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">22-24</style></issue><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">&lt;p&gt;Foreign&lt;/p&gt;</style></custom3><custom4><style face="normal" font="default" size="100%">1.065</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tiwari, Dharmendra Kumar</style></author><author><style face="normal" font="default" size="100%">Shaikh, Ashif Y.</style></author><author><style face="normal" font="default" size="100%">Pavase, Laxmikant S.</style></author><author><style face="normal" font="default" size="100%">Gumaste, Vikas K.</style></author><author><style face="normal" font="default" size="100%">Deshmukh, Abdul Rakeeb A. S.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Stereoselective synthesis of 3-alkylidene/alkylazetidin-2-ones from azetidin-2,3-diones</style></title><secondary-title><style face="normal" font="default" size="100%">Tetrahedron</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">3-diones</style></keyword><keyword><style  face="normal" font="default" size="100%">azetidin-2</style></keyword><keyword><style  face="normal" font="default" size="100%">azetidin-2-ones</style></keyword><keyword><style  face="normal" font="default" size="100%">beta-lactam</style></keyword><keyword><style  face="normal" font="default" size="100%">Grignard reaction</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2007</style></year><pub-dates><date><style  face="normal" font="default" size="100%">MAR</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">11</style></number><publisher><style face="normal" font="default" size="100%">PERGAMON-ELSEVIER SCIENCE LTD</style></publisher><pub-location><style face="normal" font="default" size="100%">THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND</style></pub-location><volume><style face="normal" font="default" size="100%">63</style></volume><pages><style face="normal" font="default" size="100%">2524-2534</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Azetidin-2,3-diones have been used as synthons for the synthesis of C-3 alkylidene/alkylazetidin-2-ones. Some of the 3-alkylazetidin-2-ones are well known for their cholesterol absorption inhibitor activity. A regio and stereoselective Grignard reaction on a keto group followed by dehydration using PPh3/CCl4 reagent is a key step in this synthesis. Hydrogenation of the 3-alkylideneazetidin-2-ones provided stereoselectively cis-3-alkylazetidin-2-ones in very good yields. (c) 2006 Published by Elsevier Ltd.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">11</style></issue><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">Foreign</style></custom3><custom4><style face="normal" font="default" size="100%">2.645</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Pandey, Satyendra Kumar</style></author><author><style face="normal" font="default" size="100%">Pandey, Menaka</style></author><author><style face="normal" font="default" size="100%">Kumar, Pradeep</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Concise synthesis of protected (2S,4R)-4-hydroxyornithine</style></title><secondary-title><style face="normal" font="default" size="100%">Tetrahedron Letters</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Epoxide</style></keyword><keyword><style  face="normal" font="default" size="100%">Grignard reaction</style></keyword><keyword><style  face="normal" font="default" size="100%">hydroxyornithine</style></keyword><keyword><style  face="normal" font="default" size="100%">Jacobsen's HKR</style></keyword><keyword><style  face="normal" font="default" size="100%">Natural product</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2008</style></year><pub-dates><date><style  face="normal" font="default" size="100%">MAY</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">20</style></number><publisher><style face="normal" font="default" size="100%">PERGAMON-ELSEVIER SCIENCE LTD</style></publisher><pub-location><style face="normal" font="default" size="100%">THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND</style></pub-location><volume><style face="normal" font="default" size="100%">49</style></volume><pages><style face="normal" font="default" size="100%">3297-3299</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;A short synthesis of the nonproteinogenic amino acid, (2S,4R)-4-hydroxyornithine is described. Starting from racemic benzyl glycidol, the scaffold of the target compound was constructed in high enantio- and diastereoselectivity using Jacobsen's hydrolytic kinetic resolution (HKR) and regioselective opening of an epoxide as key steps. (c) 2008 Elsevier Ltd. All rights reserved.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">20</style></issue><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">Foreign</style></custom3><custom4><style face="normal" font="default" size="100%">2.347</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Shingate, Bapurao B.</style></author><author><style face="normal" font="default" size="100%">Liazra, Braja G.</style></author><author><style face="normal" font="default" size="100%">Salunke, Deepak B.</style></author><author><style face="normal" font="default" size="100%">Pore, Vandana S.</style></author><author><style face="normal" font="default" size="100%">Shirazi, Fazal</style></author><author><style face="normal" font="default" size="100%">Deshpande, Mukund V.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Stereoselective synthesis and antimicrobial activity of steroidal C-20 tertiary alcohols with thiazole/pyridine side chain</style></title><secondary-title><style face="normal" font="default" size="100%">European Journal of Medicinal Chemistry</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antibacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Antifungal activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Grignard reaction</style></keyword><keyword><style  face="normal" font="default" size="100%">Steroid side chain</style></keyword><keyword><style  face="normal" font="default" size="100%">Steroidal ketones</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2011</style></year><pub-dates><date><style  face="normal" font="default" size="100%">SEP</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">9</style></number><publisher><style face="normal" font="default" size="100%">ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER</style></publisher><pub-location><style face="normal" font="default" size="100%">23 RUE LINOIS, 75724 PARIS, FRANCE</style></pub-location><volume><style face="normal" font="default" size="100%">46</style></volume><pages><style face="normal" font="default" size="100%">3681-3689</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Stereoselective synthesis of novel steroidal C-20 tertiary alcohols with thiazole and pyridine side chain using Grignard reaction of steroidal ketones and thiazole/pyridine magnesium bromide have been realized. These molecules were evaluated in vitro for their antifungal and antibacterial activities. Most of the compounds exhibited significant antifungal and antibacterial activity against all the tested strains. (C) 2011 Elsevier Masson SAS. All rights reserved.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">9</style></issue><custom3><style face="normal" font="default" size="100%">Foreign</style></custom3><custom4><style face="normal" font="default" size="100%">3.83</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kalshetti, Manojkumar G.</style></author><author><style face="normal" font="default" size="100%">Argade, Narshinha P.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Stereoselective synthesis of subincanadine alkaloids framework</style></title><secondary-title><style face="normal" font="default" size="100%">Indian Journal of Chemistry Section B-Organic Chemistry Including Medicinal Chemistry</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">(S)-Acetoxysuccinimide</style></keyword><keyword><style  face="normal" font="default" size="100%">alane reduction</style></keyword><keyword><style  face="normal" font="default" size="100%">condensation</style></keyword><keyword><style  face="normal" font="default" size="100%">Grignard reaction</style></keyword><keyword><style  face="normal" font="default" size="100%">indolizinoindolone</style></keyword><keyword><style  face="normal" font="default" size="100%">PCC-oxidation</style></keyword><keyword><style  face="normal" font="default" size="100%">stereoselective Pictet-Spengler cyclization</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">JUN</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">58</style></volume><pages><style face="normal" font="default" size="100%">669-673</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Starting from, N-tosyltryptamine and (S)-acetoxysuccinic anhydride, a facile synthesis of (-)-indolizinoindolone has been demonstrated as a basic structural outline of bioactive subincanadine alkaloids. Regioselective Grignard reaction with (S)-acetoxysuccinimide, stereoselective intramolecular cyclization to form (-)-indolizinoindolone skeleton and TiCl4 induced condensation with acetaldehyde for stereoselective generation of exocyclic carbon carbon double bond are the key features.</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">Indian</style></custom3><custom4><style face="normal" font="default" size="100%">0.388</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Majumder, Binoy</style></author><author><style face="normal" font="default" size="100%">Pandey, Ganesh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Synthesis of 2-azabicyclo[m.n.0]-alkanes and their application towards the synthesis of strychnos and stemona classes of alkaloids</style></title><secondary-title><style face="normal" font="default" size="100%">European Journal of Organic Chemistry</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">alkaloids</style></keyword><keyword><style  face="normal" font="default" size="100%">amines</style></keyword><keyword><style  face="normal" font="default" size="100%">Grignard reaction</style></keyword><keyword><style  face="normal" font="default" size="100%">Michael addition</style></keyword><keyword><style  face="normal" font="default" size="100%">Natural products</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">JUL </style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">2020</style></volume><pages><style face="normal" font="default" size="100%">3883-3888</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;2-Azabicyclo[m.n.0]alkane ring systems, the conceptual precursors towards the synthesis of Strychnos and Stemona classes of alkaloids, were synthesized from tert-butyl 2-(phenylsulfonyl)-7-aza-bicyclo[2.2.1]hept-2-ene-7-carboxylate by alkyl Grignard reaction and intramolecular cyclisation of the in situ generated ring opening product 2. The synthesized cis-hexahydroindole 3 and cis-octahydro-benzo[b]azepine 5 scaffolds were utilized to construct the advanced intermediates 25 and 35, respectively, towards the synthesis of the corresponding Strychnos and Stemona classes of alkaloids.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">25</style></issue><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">&lt;p&gt;Foreign&lt;/p&gt;
</style></custom3><custom4><style face="normal" font="default" size="100%">&lt;p&gt;2.889&lt;/p&gt;
</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Wankhede, Pranali</style></author><author><style face="normal" font="default" size="100%">Kulkarni, Amol A.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Continuous flow telescopic synthesis of 3-methoxy propiophenone by the grignard reaction</style></title><secondary-title><style face="normal" font="default" size="100%">Organic Process Research &amp; Development</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">batch and continuous reaction</style></keyword><keyword><style  face="normal" font="default" size="100%">flow chemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Grignard reaction</style></keyword><keyword><style  face="normal" font="default" size="100%">heterogeneous kinetics</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">JAN</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">29</style></volume><pages><style face="normal" font="default" size="100%">450-459</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;
	The synthesis of 3-methoxypropiophenone 1, a crucial intermediate in the production of the analgesic tapentadol hydrochloride, was investigated using a multistep continuous flow process. The approach is based on the Grignard reaction. A series of continuously stirred tank reactors (CSTRs) were employed: the first reactors facilitated the continuous generation of Grignard reagents 3, which then reacted with propionitrile in the next CSTR to yield 1. This was followed by quenching, neutralization, and phase separation, conducted under varying temperatures and residence times. When compared to a 50% yield from an optimized batch synthesis protocol, a continuous flow synthesis helped achieve an 84% yield of the desired product in a much shorter reaction time. A kinetic model was developed to predict the Grignard reagent formation and product yield, revealing that the mass transfer effect is insignificant at a higher stirring rate. The approach is highly scalable for the synthesis of pharmaceutical intermediates.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">&lt;p&gt;
	Foreign&lt;/p&gt;
</style></custom3><custom4><style face="normal" font="default" size="100%">&lt;p&gt;
	3.4&lt;/p&gt;
</style></custom4></record></records></xml>