<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">El-Dahshan, Adeeb</style></author><author><style face="normal" font="default" size="100%">Al-Gharabli, Samer I.</style></author><author><style face="normal" font="default" size="100%">Radetzki, Silke</style></author><author><style face="normal" font="default" size="100%">Al-Tel, Taleb H.</style></author><author><style face="normal" font="default" size="100%">Kumar, Pradeep</style></author><author><style face="normal" font="default" size="100%">Rademann, Joerg</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Flexible, polymer-supported synthesis of sphingosine derivatives provides ceramides with enhanced biological activity</style></title><secondary-title><style face="normal" font="default" size="100%">Bioorganic &amp; Medicinal Chemistry</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Apoptosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Ceramide</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipid rafts</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipids</style></keyword><keyword><style  face="normal" font="default" size="100%">Sphingosine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">OCT</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">19</style></number><publisher><style face="normal" font="default" size="100%">PERGAMON-ELSEVIER SCIENCE LTD</style></publisher><pub-location><style face="normal" font="default" size="100%">THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND</style></pub-location><volume><style face="normal" font="default" size="100%">22</style></volume><pages><style face="normal" font="default" size="100%">5506-5512</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;A polymer-supported route for the synthesis of sphingosine derivatives is presented based on the C-acylation of polymeric phosphoranylidene acetates with an Fmoc-protected amino acid. The approach enables the flexible variation of the sphingosine tail through a deprotection-decarboxylation sequence followed by E-selective Wittig olefination cleavage. D-Erythro-sphingosine analogs have been synthesized by diastereoselective reduction of the keto group employing LiAlH(O-tBu)(3) as reducing agent. The effect of ceramides and keto-ceramides on the proliferation of three cancer cell lines HEP G-2, PC-12 and HL-60 was investigated and a ceramide containing an aromatic sphingosine tail was identified as being most active. (C) 2014 Elsevier Ltd. All rights reserved.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">19</style></issue><custom3><style face="normal" font="default" size="100%">Foreign</style></custom3><custom4><style face="normal" font="default" size="100%">1.57</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Limbkar, Kedar</style></author><author><style face="normal" font="default" size="100%">Dhenge, Ankita</style></author><author><style face="normal" font="default" size="100%">Jadhav, Dipesh D.</style></author><author><style face="normal" font="default" size="100%">Thulasiram, Hirekodathakallu V.</style></author><author><style face="normal" font="default" size="100%">Kale, Vaijayanti</style></author><author><style face="normal" font="default" size="100%">Limaye, Lalita</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Oral feeding with polyunsaturated fatty acids fosters hematopoiesis and thrombopoiesis in healthy and bone marrow-transplanted mice</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Nutritional Biochemistry</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bone Marrow Transplantation (Bmt)</style></keyword><keyword><style  face="normal" font="default" size="100%">Cord Blood</style></keyword><keyword><style  face="normal" font="default" size="100%">Down-regulation</style></keyword><keyword><style  face="normal" font="default" size="100%">Ex-vivo Expansion</style></keyword><keyword><style  face="normal" font="default" size="100%">Hematopoiesis</style></keyword><keyword><style  face="normal" font="default" size="100%">Hematopoietic Stem Cells (Hscs)</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipid rafts</style></keyword><keyword><style  face="normal" font="default" size="100%">Myocardial-infarction</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyunsaturated Fatty Acids</style></keyword><keyword><style  face="normal" font="default" size="100%">Progenitor Cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Prostaglandin-e2</style></keyword><keyword><style  face="normal" font="default" size="100%">Self-renewal</style></keyword><keyword><style  face="normal" font="default" size="100%">Spleen Colonies</style></keyword><keyword><style  face="normal" font="default" size="100%">Stem-cell Proliferation</style></keyword><keyword><style  face="normal" font="default" size="100%">Thrombopoiesis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">sep</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">47</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;span style=&quot;color: rgb(51, 51, 51); font-family: arial, helvetica, sans-serif; font-size: 13px; background-color: rgb(248, 248, 248);&quot;&gt;Hematopoietic stem cells play the vital role of maintaining appropriate levels of cells in blood. Therefore, regulation of their fate is essential for their effective therapeutic use. Here we report the role of polyunsaturated fatty acids (PUFAs) in regulating hematopoiesis which has not been explored well so far. Mice were fed daily for 10 days with n-6/n-3 PUFAs, viz. linoleic acid (LA), arachidonic acid (AA), alpha-linolenic acid and docosahexanoic acid (DHA) in four separate test groups with phosphate-buffered saline fed mice as control set. The bone marrow cells of PUFA-fed mice showed a significantly higher hematopoiesis as assessed using side population, Lin-Sca-1(+)ckit+, colony-forming unit (CFU), long-term culture, CFU-spleen assay and engraftment potential as compared to the control set. Thrombopoiesis was also stimulated in PUFA-fed mice. A combination of DHA and AA was found to be more effective than when either was fed individually. Higher incorporation of PUFAs as well as products of their metabolism was observed in the bone marrow cells of PUFA-fed mice. A stimulation of the Wnt, CXCR4 and Notch1 pathways was observed in PUFA-fed mice. The clinical relevance of this study was evident when bone marrow-transplanted recipient mice, which were fed with PUFAs, showed higher engraftment of donor cells, suggesting that the bone marrow microenvironment may also be stimulated by feeding with PUFAs. These data indicate that oral administration of PUFAs in mice stimulates hematopoiesis and thrombopoiesis and could serve as a valuable supplemental therapy in situations of hematopoietic failure. (C) 2017 Elsevier Inc. All rights reserved.&lt;/span&gt;&lt;/p&gt;</style></abstract><custom3><style face="normal" font="default" size="100%">Foreign</style></custom3><custom4><style face="normal" font="default" size="100%">&lt;p&gt;4.668&lt;/p&gt;</style></custom4><section><style face="normal" font="default" size="100%">94-105</style></section></record></records></xml>