<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Avhad, V. Shankarrao</style></author><author><style face="normal" font="default" size="100%">Choudhari, Shakeb N.</style></author><author><style face="normal" font="default" size="100%">Ambade, V. Ashootosh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Photo and pH dual stimuli-responsive block copolymer micelles with defined incorporation of o-nitrobenzyl units in poly(ε-caprolactone) ε-caprolactone) block for controlled release</style></title><secondary-title><style face="normal" font="default" size="100%">European Polymer Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">drug delivery</style></keyword><keyword><style  face="normal" font="default" size="100%">micelles</style></keyword><keyword><style  face="normal" font="default" size="100%">O-nitrobenzyl</style></keyword><keyword><style  face="normal" font="default" size="100%">pH-responsive</style></keyword><keyword><style  face="normal" font="default" size="100%">Photoresponsive</style></keyword><keyword><style  face="normal" font="default" size="100%">Poly(epsilon-caprolactone)</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">NOV</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">220</style></volume><pages><style face="normal" font="default" size="100%">113501</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;
	A series of dual stimuli-responsive block copolymers with varying content of photocleavable o-nitrobenzyl (ONB) ester group pendent in the hydrophobic poly(epsilon-caprolactone) block and pH-cleavable acetal linkage at the junction with hydrophilic poly(ethylene glycol) block is synthesized. The hydrophobic block is a random copolymer synthesized by ring-opening copolymerization of epsilon-caprolactone and ONB-substituted epsilon-caprolactone containing varying compositions of the two monomers. Kinetics of polymerization shows that ONBfunctionalized monomer has lower reactivity than that of the unsubstituted monomer. The series of block copolymers shows self-assembly into well-defined spherical micelles of average size of 150-200 nm in aqueous solution. Photocleavage of ONB groups is studied by NMR and UV-vis spectroscopy, and its extent is determined. The two stimuli viz. . UV light and pH are used individually as well as simultaneously to study the controlled release of the encapsulated drug Camptothecin and the synergistic effect of the two stimuli is demonstrated. The effect of varying content of ONB groups is observed on drug release profile. MTT assay showed non-cytotoxic nature of the polymer. Cell uptake and photoinduced release of doxorubicin (DOX) from the micelles in MDAMB-231 cells is demonstrated.&lt;/p&gt;
</style></abstract><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">&lt;p&gt;
	Foreign&lt;/p&gt;
</style></custom3><custom4><style face="normal" font="default" size="100%">&lt;p&gt;
	6&lt;/p&gt;
</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Basutkar, Nitin B.</style></author><author><style face="normal" font="default" size="100%">Surapaneni, Sai Geetika</style></author><author><style face="normal" font="default" size="100%">Alam, Md. Shafi</style></author><author><style face="normal" font="default" size="100%">Ambade, Ashootosh V.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Visible light and pH-responsive star copolymer and doxorubicin-polymer conjugate micelles for combination drug delivery and bioimaging</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of macromolecular science part A- pure and applied chemistry</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">BODIPY</style></keyword><keyword><style  face="normal" font="default" size="100%">drug conjugate</style></keyword><keyword><style  face="normal" font="default" size="100%">micelles</style></keyword><keyword><style  face="normal" font="default" size="100%">pH-responsive</style></keyword><keyword><style  face="normal" font="default" size="100%">visible light-responsive</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">FEB </style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">61</style></volume><pages><style face="normal" font="default" size="100%">105-116</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;
	Amphiphilic 3-arm star copolymer containing visible light-cleavable BODIPY group and pH-responsive imine bonds at the junction of hydrophilic poly(ethylene glycol) (PEG) and two poly(epsilon-caprolactone) (PCL) arms was synthesized by the combination of ring-opening polymerization (ROP) and click chemistry. The formation and stimuli-responsive disruption of micelles were analyzed using dynamic light scattering and transmission electron microscopy. Dual stimuli-responsive release of anticancer drugs Doxorubicin (Dox) and Camptothecin (CPT) from the micelles was studied. Micellar assemblies containing Dox conjugated to PEG-BODIPY through imine bonds were prepared and controlled release of Dox in response to visible light and pH was shown. CPT and Dox-loaded star copolymer micelles as well as CPT loaded Dox-conjugated micelles were used in cellular uptake studies on MDA-MB 231 cells, and the synergistic effect of the two stimuli on the release of the two drugs was demonstrated inside the cells. Micellar assemblies also showed excellent bioimaging properties in the cellular uptake studies. [GRAPHICS]&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">&lt;p&gt;
	Foreign&lt;/p&gt;
</style></custom3><custom4><style face="normal" font="default" size="100%">&lt;p&gt;
	2.5&lt;/p&gt;
</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Patil, Anil M.</style></author><author><style face="normal" font="default" size="100%">Nawghare, Indrajeet S.</style></author><author><style face="normal" font="default" size="100%">Siby, Jesna</style></author><author><style face="normal" font="default" size="100%">Bankar, Priyanka M.</style></author><author><style face="normal" font="default" size="100%">Dastager, Syed G.</style></author><author><style face="normal" font="default" size="100%">Rode, Chandrashekhar V.</style></author><author><style face="normal" font="default" size="100%">Nithyanandhan, Jayaraj</style></author><author><style face="normal" font="default" size="100%">Ambade, Ashootosh V.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">pH-Responsive and antimicrobial polymer synthesis in continuous flow and effect of pendant alkylamine on the squaraine dye photocatalyst activity</style></title><secondary-title><style face="normal" font="default" size="100%">ACS Applied Polymer Materials</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">alkylaminoethyl methacrylate</style></keyword><keyword><style  face="normal" font="default" size="100%">Antimicrobial</style></keyword><keyword><style  face="normal" font="default" size="100%">continuous flowprocess</style></keyword><keyword><style  face="normal" font="default" size="100%">PET-RAFT</style></keyword><keyword><style  face="normal" font="default" size="100%">pH-responsive</style></keyword><keyword><style  face="normal" font="default" size="100%">self-aggregation</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2026</style></year><pub-dates><date><style  face="normal" font="default" size="100%">MAY</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">6287-6300</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;
	pH-responsive and antimicrobial polymers were synthesized by photoinduced electron transfer-reversible addition-fragmentation chain transfer (PET-RAFT) polymerization under blue light (lambda max = 485 nm) using a scalable continuous flow method. The effect of pendant alkylamino groups with different alkyl substituents on methacrylate monomers under blue light is investigated in the absence of a tertiary alkylamine reagent and in the presence of cyanopentanoic acid dithiobenzoate and 4-cyano-4-[(dodecylsulfanylthiocarbonyl) sulfanyl]pentanoic acid as RAFT agents. The rate of polymerization is found to vary with the size of the alkyl chain and with the tertiary, secondary, or quaternary nature of the amino group. The ability of pendant alkylamino groups to transfer electrons to the photocatalyst is shown using cyclic voltammetry and fluorescence quenching experiments; the tendency to suppress dye aggregation is observed using UV-vis spectroscopy; and the rates of polymerization could be correlated with the trend in these results. The mechanism of polymerization is proposed to follow a reductive or oxidative electron transfer pathway depending on the nature of the pendant group. Statistical and diblock copolymers with 2-hydroxyethyl methacrylate are synthesized in batch and continuous flow processes with a comparative study of kinetics in the two methods. The synthesis of high-molecular-weight homopolymer (55,000 g/mol) and statistical copolymer (85,000 g/mol) of N,N-diisopropylaminoethyl methacrylate is shown in continuous flow. The solution self-assembly of diblock copolymers is studied, and the pH-responsive morphology change leading to disassembly is shown. The antimicrobial properties of polymers with a quaternary ammonium pendant group are evaluated. The thermal degradation of statistical copolymers is analyzed.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">9</style></issue><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">&lt;p&gt;
	Foreign&lt;/p&gt;
</style></custom3><custom4><style face="normal" font="default" size="100%">&lt;p&gt;
	5.0&lt;/p&gt;
</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Avhad, Shankarrao V.</style></author><author><style face="normal" font="default" size="100%">Surapaneni, Sai Geetika</style></author><author><style face="normal" font="default" size="100%">Purohit, Poorvi M.</style></author><author><style face="normal" font="default" size="100%">Ambade, Ashootosh V.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Redox- and pH-responsive block copolymer nanocarriers with dual drug conjugation through dynamic covalent and hydrogen bonds</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Applied Polymer Science</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">biodegradable</style></keyword><keyword><style  face="normal" font="default" size="100%">copolymers</style></keyword><keyword><style  face="normal" font="default" size="100%">DOX-conjugate</style></keyword><keyword><style  face="normal" font="default" size="100%">drug delivery systems</style></keyword><keyword><style  face="normal" font="default" size="100%">methotrexate</style></keyword><keyword><style  face="normal" font="default" size="100%">micelles</style></keyword><keyword><style  face="normal" font="default" size="100%">pH-responsive</style></keyword><keyword><style  face="normal" font="default" size="100%">redox-responsive</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2026</style></year><pub-dates><date><style  face="normal" font="default" size="100%">MAR</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">143</style></volume><pages><style face="normal" font="default" size="100%">e70205</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;
	Loading of multiple drugs in a nanocarrier with high entrapment efficiency is important for combination therapy in cancer treatment. Here, a block copolymer comprising hydrophobic poly(epsilon-caprolactone) block with a defined number of pendent propargyl groups, polyethylene glycol monomethyl ether as a hydrophilic block, and a redox-responsive disulfide group at the block junction is synthesized using click chemistry and ring-opening polymerization (ROP). Benzaldehyde and thymine groups are introduced in the side chains for selective attachment of anti-cancer drugs, doxorubicin (DOX) and methotrexate (MTX), via the formation of pH-responsive imine linkage and hydrogen bonds, respectively. The drug-conjugated block copolymers are assembled into spherical micelles of &amp;lt; 200 nm, and the preferential release of DOX and MTX in response to acidic pH and redox conditions is shown. At pH 5, DOX release was 59.5%, and MTX release was 40% compared to 13% and 12% at pH 7.4, whereas at pH 5 with 10 mM GSH, a DOX release of 81.5% was observed after 48 h. Cellular uptake of drug-conjugated micelles and their apoptosis compared to free DOX in the MDA-MB-231 breast cancer cells is demonstrated. Caveolae-mediated endocytosis was found to be the major pathway used by drug-loaded nanocarriers.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">10</style></issue><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">&lt;p&gt;
	Foreign&lt;/p&gt;
</style></custom3><custom4><style face="normal" font="default" size="100%">&lt;p&gt;
	2.8&lt;/p&gt;
</style></custom4></record></records></xml>