<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Walunj, Sameer</style></author><author><style face="normal" font="default" size="100%">Gupta, Rajesh</style></author><author><style face="normal" font="default" size="100%">Joshi, Swati P.</style></author><author><style face="normal" font="default" size="100%">Sabharwal, Sushma G.</style></author><author><style face="normal" font="default" size="100%">Joshi, Kalpana</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Lannea coromandelica attenuates glucagon and oxyntomodulin mediated cAMP formation in HEK cells stably-expressing human glucagon receptor</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Herbal Medicine</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">cAMP</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">Glucagon</style></keyword><keyword><style  face="normal" font="default" size="100%">Lannea coromandelica</style></keyword><keyword><style  face="normal" font="default" size="100%">Mechanism</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxyntomodulin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">SEP</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">3</style></number><publisher><style face="normal" font="default" size="100%">ELSEVIER GMBH, URBAN &amp; FISCHER VERLAG</style></publisher><pub-location><style face="normal" font="default" size="100%">OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY</style></pub-location><volume><style face="normal" font="default" size="100%">5</style></volume><pages><style face="normal" font="default" size="100%">153-157</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Antagonism of glucagon is a potential therapeutic approach for Type 2 diabetes mellitus (T2DM). The bark extract of Lannea coromandelica has been reported to have hypoglycemic or anti-diabetic effects on animal models and human subjects. The aim of this study was to elucidate the molecular mechanisms of L. coromandelica extract as a glucagon receptor antagonist. The aqueous extract of L. coromandelica bark attenuated glucagon-mediated cAMP formation in a concentration dependent manner with an IC50 value of 4.24 +/- 1.31 mu g/ml. It shifted a concentration response curve of glucagon towards the right with a 4, 21 and 40-fold change in IC50 at 6.25, 12.5 and 25 mu g/ml of extract, respectively. Additionally, it attenuated an oxyntomodulin-mediated cAMP response. The extract was found specifically to inhibit glucagon mediated cAMP formation since it was ineffective in reducing cAMP levels nonspecifically-elevated by forskolin. The data support that the aqueous extract of L. coromandelica antagonizes the glucagon receptor and has the potential to reduce glucagon mediated liver glucose output. (C) 2015 Elsevier GmbH. All rights reserved.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><custom3><style face="normal" font="default" size="100%">&lt;p&gt;Foreign&lt;/p&gt;</style></custom3><custom4><style face="normal" font="default" size="100%">1.2</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Javir, Gitanjali</style></author><author><style face="normal" font="default" size="100%">Joshi, Kalpana</style></author><author><style face="normal" font="default" size="100%">Khedkar, Vijay</style></author><author><style face="normal" font="default" size="100%">Rojatkar, Supada</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">6 alpha-Hydroxy-4[14], 10[15]-guainadien-8 beta, 12-olide induced cell cycle arrest via modulation of EMT and Wnt/beta-catenin pathway in HER-2 positive breast cancer cells</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Steroid Biochemistry and Molecular Biology</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">beta-Catenin</style></keyword><keyword><style  face="normal" font="default" size="100%">EMT</style></keyword><keyword><style  face="normal" font="default" size="100%">Guaianolide</style></keyword><keyword><style  face="normal" font="default" size="100%">HER-2 inhibitor</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">MAR</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">197</style></volume><pages><style face="normal" font="default" size="100%">105514</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Cyathocline purpurea has potential biological activities and has been widely used in traditional Chinese and Ayurvedic medicine. The aim of the present study is to elucidate the anticancer effect of its 6 alpha-hydroxy-4[14], 10 [15]-guainadien-8 beta, 12-olide (SRCP1) against HER-2 positive subtype of breast carcinoma. Anticancer effect of SRCP1 was assessed by cell viability, senescence, apoptosis, cell cycle, DNA synthesis, and gene expression assays. The activity was further validated by the molecular docking study. SRCP1 inhibits human HER-2 positive breast cancer growth via inhibition of DNA synthesis in a dose-dependent manner. SRCP1 induces cell cycle arrest at G(2)/M phase, late apoptosis, and necrosis. Further, it induces senescence causing reduction in migration via down-regulation of EMT. A remarkable increase in the number of necrotic cells and Annexin-V staining revealed that exposure to SRCP1 triggers late apoptosis. Treatment with SRCP1 increased E-cadherin, p21, p53, ER-alpha expression and decreased beta-catenin, MMP-9, snaill, TNF-alpha expression. SRCP1 showed binding affinity towards an active site of the HER-2 receptor. Our results of molecular docking and biological assays demonstrated the potent anticancer activity of SRCP1 in MDA-MB-453 cells via multiple pathways including EMT, TNF-alpha, and Wnt/beta-catenin signaling.&lt;/p&gt;
</style></abstract><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">&lt;p&gt;Foreign&lt;/p&gt;
</style></custom3><custom4><style face="normal" font="default" size="100%">&lt;p&gt;3.813&lt;/p&gt;
</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kashid, Shweta</style></author><author><style face="normal" font="default" size="100%">Joshi, Kalpana</style></author><author><style face="normal" font="default" size="100%">Nene, Sanjay</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparison of hydrodynamic characteristics of Tulsion and Siran immobilised beads in a fluidised bed bioreactor</style></title><secondary-title><style face="normal" font="default" size="100%">Biocatalysis and Agricultural Biotechnology</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">AUG</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">43</style></volume><pages><style face="normal" font="default" size="100%">102428</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;
	&lt;span style=&quot;box-sizing: border-box; margin: 0px; padding: 0px; color: rgb(46, 46, 46); font-family: ElsevierGulliver, Georgia, &amp;quot;Times New Roman&amp;quot;, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, Arial, Helvetica, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif; font-size: 16px;&quot;&gt;The fluidised bed reactors are successfully utilised in various bioprocesses to produce&amp;nbsp;&lt;a class=&quot;topic-link&quot; href=&quot;https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/high-value-products&quot; style=&quot;box-sizing: border-box; margin: 0px; padding: 0px; background-color: transparent; word-break: break-word; text-decoration-thickness: 1px; text-decoration-color: rgb(46, 46, 46); color: rgb(46, 46, 46); text-underline-offset: 1px;&quot; title=&quot;Learn more about high value products from ScienceDirect's AI-generated Topic Pages&quot;&gt;high value products&lt;/a&gt;&lt;span style=&quot;box-sizing: border-box; margin: 0px; padding: 0px;&quot;&gt;&amp;nbsp;using&amp;nbsp;&lt;a class=&quot;topic-link&quot; href=&quot;https://www.sciencedirect.com/topics/immunology-and-microbiology/immobilized-cell&quot; style=&quot;box-sizing: border-box; margin: 0px; padding: 0px; background-color: transparent; word-break: break-word; text-decoration-thickness: 1px; text-decoration-color: rgb(46, 46, 46); color: rgb(46, 46, 46); text-underline-offset: 1px;&quot; title=&quot;Learn more about immobilised cells from ScienceDirect's AI-generated Topic Pages&quot;&gt;immobilised cells&lt;/a&gt;&lt;span style=&quot;box-sizing: border-box; margin: 0px; padding: 0px;&quot;&gt;&lt;span style=&quot;box-sizing: border-box; margin: 0px; padding: 0px;&quot;&gt;&amp;nbsp;and enzymes. The present work aims at evaluating hydrodynamic characteristics of a three phase fluidised bed&amp;nbsp;&lt;a class=&quot;topic-link&quot; href=&quot;https://www.sciencedirect.com/topics/immunology-and-microbiology/bioreactor&quot; style=&quot;box-sizing: border-box; margin: 0px; padding: 0px; background-color: transparent; word-break: break-word; text-decoration-thickness: 1px; text-decoration-color: rgb(46, 46, 46); color: rgb(46, 46, 46); text-underline-offset: 1px;&quot; title=&quot;Learn more about bioreactor from ScienceDirect's AI-generated Topic Pages&quot;&gt;bioreactor&lt;/a&gt;&lt;span style=&quot;box-sizing: border-box; margin: 0px; padding: 0px;&quot;&gt;&amp;nbsp;using Tulsion® A-1X MP, Tulsion® ADS-400 and Tulsion® ADS-800,&amp;nbsp;&lt;a class=&quot;topic-link&quot; href=&quot;https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/polystyrene&quot; style=&quot;box-sizing: border-box; margin: 0px; padding: 0px; background-color: transparent; word-break: break-word; text-decoration-thickness: 1px; text-decoration-color: rgb(46, 46, 46); color: rgb(46, 46, 46); text-underline-offset: 1px;&quot; title=&quot;Learn more about polystyrene from ScienceDirect's AI-generated Topic Pages&quot;&gt;polystyrene&lt;/a&gt;&lt;span style=&quot;box-sizing: border-box; margin: 0px; padding: 0px;&quot;&gt;&amp;nbsp;and polyacrylic based three types of free and&amp;nbsp;&lt;a class=&quot;topic-link&quot; href=&quot;https://www.sciencedirect.com/topics/immunology-and-microbiology/immobilized-cell&quot; style=&quot;box-sizing: border-box; margin: 0px; padding: 0px; background-color: transparent; word-break: break-word; text-decoration-thickness: 1px; text-decoration-color: rgb(46, 46, 46); color: rgb(46, 46, 46); text-underline-offset: 1px;&quot; title=&quot;Learn more about immobilised cells from ScienceDirect's AI-generated Topic Pages&quot;&gt;immobilised cells&lt;/a&gt;&amp;nbsp;solid carriers viz. and comparing their performance with Siran® SIKUG41 glass beads. The hydrodynamic parameters such as particle density (cells and beads), drag coefficient, minimum and maximum&amp;nbsp;&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;a class=&quot;topic-link&quot; href=&quot;https://www.sciencedirect.com/topics/immunology-and-microbiology/fluidization&quot; style=&quot;box-sizing: border-box; margin: 0px; padding: 0px; background-color: transparent; word-break: break-word; text-decoration-thickness: 1px; text-decoration-color: rgb(46, 46, 46); color: rgb(46, 46, 46); text-underline-offset: 1px;&quot; title=&quot;Learn more about fluidisation from ScienceDirect's AI-generated Topic Pages&quot;&gt;fluidisation&lt;/a&gt;&amp;nbsp;velocity, particle settling velocity were estimated and compared in water and biological media (E2 and MSM) having varying rheological properties. The relationships between drag coefficient (C&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;span style=&quot;box-sizing: border-box; margin: 0px; padding: 0px; line-height: 0; position: relative; vertical-align: baseline; bottom: -0.25em; color: rgb(46, 46, 46); font-family: ElsevierGulliver, Georgia, &amp;quot;Times New Roman&amp;quot;, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, Arial, Helvetica, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif;&quot;&gt;D&lt;/span&gt;&lt;span style=&quot;color: rgb(46, 46, 46); font-family: ElsevierGulliver, Georgia, &amp;quot;Times New Roman&amp;quot;, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, Arial, Helvetica, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif; font-size: 16px;&quot;&gt;)–Reynolds numbers (N&lt;/span&gt;&lt;span style=&quot;box-sizing: border-box; margin: 0px; padding: 0px; line-height: 0; position: relative; vertical-align: baseline; bottom: -0.25em; color: rgb(46, 46, 46); font-family: ElsevierGulliver, Georgia, &amp;quot;Times New Roman&amp;quot;, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, Arial, Helvetica, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif;&quot;&gt;Re&lt;/span&gt;&lt;span style=&quot;color: rgb(46, 46, 46); font-family: ElsevierGulliver, Georgia, &amp;quot;Times New Roman&amp;quot;, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, Arial, Helvetica, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif; font-size: 16px;&quot;&gt;), superficial liquid velocity (U&lt;/span&gt;&lt;span style=&quot;box-sizing: border-box; margin: 0px; padding: 0px; line-height: 0; position: relative; vertical-align: baseline; bottom: -0.25em; color: rgb(46, 46, 46); font-family: ElsevierGulliver, Georgia, &amp;quot;Times New Roman&amp;quot;, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, Arial, Helvetica, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif;&quot;&gt;f&lt;/span&gt;&lt;span style=&quot;color: rgb(46, 46, 46); font-family: ElsevierGulliver, Georgia, &amp;quot;Times New Roman&amp;quot;, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, Arial, Helvetica, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif; font-size: 16px;&quot;&gt;)–void fraction(ε), expansion index(n)–N&lt;/span&gt;&lt;span style=&quot;box-sizing: border-box; margin: 0px; padding: 0px; line-height: 0; position: relative; vertical-align: baseline; bottom: -0.25em; color: rgb(46, 46, 46); font-family: ElsevierGulliver, Georgia, &amp;quot;Times New Roman&amp;quot;, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, Arial, Helvetica, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif;&quot;&gt;Re&lt;/span&gt;&lt;span style=&quot;color: rgb(46, 46, 46); font-family: ElsevierGulliver, Georgia, &amp;quot;Times New Roman&amp;quot;, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, Arial, Helvetica, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif; font-size: 16px;&quot;&gt;&amp;nbsp;were obtained.&lt;/span&gt;&lt;/p&gt;
</style></abstract><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">&lt;p&gt;
	Foreign&lt;/p&gt;
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