<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Patil, Sharvil S.</style></author><author><style face="normal" font="default" size="100%">Venugopal, Edakkal</style></author><author><style face="normal" font="default" size="100%">Bhat, Suresh K.</style></author><author><style face="normal" font="default" size="100%">Mahadik, Kakasaheb R.</style></author><author><style face="normal" font="default" size="100%">Paradkar, Anant R.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Microstructural elucidation of self-emulsifying system: effect of chemical structure</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmaceutical Research</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">emulsion</style></keyword><keyword><style  face="normal" font="default" size="100%">flurbiprofen</style></keyword><keyword><style  face="normal" font="default" size="100%">ibuprofen</style></keyword><keyword><style  face="normal" font="default" size="100%">ketoprofen</style></keyword><keyword><style  face="normal" font="default" size="100%">lamellar structure</style></keyword><keyword><style  face="normal" font="default" size="100%">self-emulsifying system</style></keyword><keyword><style  face="normal" font="default" size="100%">structural analogues</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2012</style></year><pub-dates><date><style  face="normal" font="default" size="100%">AUG</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">8</style></number><publisher><style face="normal" font="default" size="100%">SPRINGER/PLENUM PUBLISHERS</style></publisher><pub-location><style face="normal" font="default" size="100%">233 SPRING ST, NEW YORK, NY 10013 USA</style></pub-location><volume><style face="normal" font="default" size="100%">29</style></volume><pages><style face="normal" font="default" size="100%">2180-2188</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Self-emulsifying systems (SES) emulsify spontaneously to produce fine oil-in-water emulsion when introduced into aqueous phase. The self-emulsification process plays an important role during formation of emulsion. The objective of current work was to understand and explore the inner structuration of SES through controlled hydration and further to study the influence of additive on the same which ultimately governs performance of final formulation in terms of droplet size. Droplet size of final formulations containing structural analogues of ibuprofen was determined. Microstructural properties of intermediate hydrated regimes of SES were investigated using techniques such as small angle X-ray scattering, differential scanning calorimetry and rheology. The current work established inverse relationship between droplet size of the formulations containing structural analogues of ibuprofen and their Log P values. Microstructural analysis of intermediate hydrated regimes of the prepared samples showed formation of local lamellar structure. Structural analogues of ibuprofen significantly altered microstructure of lamellae which was well correlated with the droplet size of final formulations. In vitro drug release study showed increase in dissolution rate of lipophillic drugs when formulated as SES. The current work emphasizes the fact that tailor-made formulations can be prepared by controlling the properties of intermediate regimes.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">8</style></issue><custom3><style face="normal" font="default" size="100%">Foreign</style></custom3><custom4><style face="normal" font="default" size="100%">4.742
</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Patil, Sharvil S.</style></author><author><style face="normal" font="default" size="100%">Venugopal, Edakkal</style></author><author><style face="normal" font="default" size="100%">Bhat, Suresh K.</style></author><author><style face="normal" font="default" size="100%">Mahadik, Kakasaheb R.</style></author><author><style face="normal" font="default" size="100%">Paradkar, Anant R.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Mapping ion-induced mesophasic transformation in lyotropic in situ gelling system and its correlation with pharmaceutical performance</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmaceutical Research</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">cubic phase</style></keyword><keyword><style  face="normal" font="default" size="100%">hexagonal phase</style></keyword><keyword><style  face="normal" font="default" size="100%">liquid crystal</style></keyword><keyword><style  face="normal" font="default" size="100%">mesophasic transformation</style></keyword><keyword><style  face="normal" font="default" size="100%">sustained drug release</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2013</style></year><pub-dates><date><style  face="normal" font="default" size="100%">JUL</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">7</style></number><publisher><style face="normal" font="default" size="100%">SPRINGER/PLENUM PUBLISHERS</style></publisher><pub-location><style face="normal" font="default" size="100%">233 SPRING ST, NEW YORK, NY 10013 USA</style></pub-location><volume><style face="normal" font="default" size="100%">30</style></volume><pages><style face="normal" font="default" size="100%">1906-1914</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;To investigate influence of ion induced mesophasic transformation on pharmaceutical performance of in situ gelling system consisting of glyceryl monooleate. The prepared system showed mesophasic transformation during its conversion from sol to gel upon controlled hydration. The process of mesophasic transformation was studied by SAXS, DSC, rheology and plane polarized light microscopy. Further the influence of additives i.e. naproxen salts (sodium and potassium) and naproxen (base) on the process of mesophasic transformation was also elucidated. It was observed that addition of salt form of naproxen transformed W/O emulsions into cubic mesophase whereas addition of base form of naproxen formed reverse hexagonal (H-II) phase upon controlled hydration. The cubic mesophase formed by naproxen salts retarded the drug release for initial 3 h whereas H-II phase showed sustained drug release characteristics for naproxen base following Higuchi drug release kinetics. The current work suggests that formulations with tailor made pharmaceutical performance can be developed by selecting proper additives in the system so as to obtain the desired mesophase `on demand' thereby controlling drug release characteristics.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">7</style></issue><custom3><style face="normal" font="default" size="100%">Foreign</style></custom3><custom4><style face="normal" font="default" size="100%">3.952
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