<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Venugopal, Edakkal</style></author><author><style face="normal" font="default" size="100%">Bhat, Suresh K.</style></author><author><style face="normal" font="default" size="100%">Vallooran, Jijo J.</style></author><author><style face="normal" font="default" size="100%">Mezzenga, Raffaele</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phase behavior of lipid-based lyotropic liquid crystals in presence of colloidal nanoparticles</style></title><secondary-title><style face="normal" font="default" size="100%">Langmuir</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2011</style></year><pub-dates><date><style  face="normal" font="default" size="100%">AUG</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">16</style></number><publisher><style face="normal" font="default" size="100%">AMER CHEMICAL SOC</style></publisher><pub-location><style face="normal" font="default" size="100%">1155 16TH ST, NW, WASHINGTON, DC 20036 USA</style></pub-location><volume><style face="normal" font="default" size="100%">27</style></volume><pages><style face="normal" font="default" size="100%">9792-9800</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;We have investigated the microstructure and phase behavior of monoglyceride-based lyotropic liquid crystals in the presence of hydrophilic silica colloidal particles of size comparable to or slightly exceeding the repeat units of the different liquid crystalline phases. Using small angle X-ray scattering (SAXS) and differential scanning calorimetry (DSC), we compare the structural properties of the neat mesophases with those of the systems containing silica colloidal particles. It is found that the colloidal particles always macrophase separate in inverse bicontinuous cubic phases of gyroid (Ia3d) and double diamond (Pn3m) symmetries. SAXS data for the inverse columnar hexagonal phase (H(II)) and lamellar phase (L(alpha)) suggest that a low volume fraction of the nanoparticles can be accommodated within the mesophases, but that at concentrations above a given threshold, the particles do macrophase separate also in these systems. The behavior is interpreted in terms of the enthalpic and entropic interactions of the nanoparticles with the lamellar and hexagonal phases, and we propose that, in the low concentration limit, the nanoparticles are acting as point defects within the mesophases and, upon further increase in concentration, initiate nucleation of nanoparticles dusters, leading to a macroscopic phase separation.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">16</style></issue><custom3><style face="normal" font="default" size="100%">Foreign</style></custom3><custom4><style face="normal" font="default" size="100%">4.186
</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Patil, Sharvil S.</style></author><author><style face="normal" font="default" size="100%">Venugopal, Edakkal</style></author><author><style face="normal" font="default" size="100%">Bhat, Suresh K.</style></author><author><style face="normal" font="default" size="100%">Mahadik, Kakasaheb R.</style></author><author><style face="normal" font="default" size="100%">Paradkar, Anant R.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Microstructural elucidation of self-emulsifying system: effect of chemical structure</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmaceutical Research</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">emulsion</style></keyword><keyword><style  face="normal" font="default" size="100%">flurbiprofen</style></keyword><keyword><style  face="normal" font="default" size="100%">ibuprofen</style></keyword><keyword><style  face="normal" font="default" size="100%">ketoprofen</style></keyword><keyword><style  face="normal" font="default" size="100%">lamellar structure</style></keyword><keyword><style  face="normal" font="default" size="100%">self-emulsifying system</style></keyword><keyword><style  face="normal" font="default" size="100%">structural analogues</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2012</style></year><pub-dates><date><style  face="normal" font="default" size="100%">AUG</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">8</style></number><publisher><style face="normal" font="default" size="100%">SPRINGER/PLENUM PUBLISHERS</style></publisher><pub-location><style face="normal" font="default" size="100%">233 SPRING ST, NEW YORK, NY 10013 USA</style></pub-location><volume><style face="normal" font="default" size="100%">29</style></volume><pages><style face="normal" font="default" size="100%">2180-2188</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Self-emulsifying systems (SES) emulsify spontaneously to produce fine oil-in-water emulsion when introduced into aqueous phase. The self-emulsification process plays an important role during formation of emulsion. The objective of current work was to understand and explore the inner structuration of SES through controlled hydration and further to study the influence of additive on the same which ultimately governs performance of final formulation in terms of droplet size. Droplet size of final formulations containing structural analogues of ibuprofen was determined. Microstructural properties of intermediate hydrated regimes of SES were investigated using techniques such as small angle X-ray scattering, differential scanning calorimetry and rheology. The current work established inverse relationship between droplet size of the formulations containing structural analogues of ibuprofen and their Log P values. Microstructural analysis of intermediate hydrated regimes of the prepared samples showed formation of local lamellar structure. Structural analogues of ibuprofen significantly altered microstructure of lamellae which was well correlated with the droplet size of final formulations. In vitro drug release study showed increase in dissolution rate of lipophillic drugs when formulated as SES. The current work emphasizes the fact that tailor-made formulations can be prepared by controlling the properties of intermediate regimes.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">8</style></issue><custom3><style face="normal" font="default" size="100%">Foreign</style></custom3><custom4><style face="normal" font="default" size="100%">4.742
</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Patil, Sharvil S.</style></author><author><style face="normal" font="default" size="100%">Venugopal, Edakkal</style></author><author><style face="normal" font="default" size="100%">Bhat, Suresh K.</style></author><author><style face="normal" font="default" size="100%">Mahadik, Kakasaheb R.</style></author><author><style face="normal" font="default" size="100%">Paradkar, Anant R.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Probing influence of mesophasic transformation on performance of self-emulsifying system: effect of ion</style></title><secondary-title><style face="normal" font="default" size="100%">Molecular Pharmaceutics</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">emulsion</style></keyword><keyword><style  face="normal" font="default" size="100%">lamellar structure</style></keyword><keyword><style  face="normal" font="default" size="100%">liquid crystal</style></keyword><keyword><style  face="normal" font="default" size="100%">Microstructure</style></keyword><keyword><style  face="normal" font="default" size="100%">Naproxen</style></keyword><keyword><style  face="normal" font="default" size="100%">self-emulsifying system</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2012</style></year><pub-dates><date><style  face="normal" font="default" size="100%">FEB</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">2</style></number><publisher><style face="normal" font="default" size="100%">AMER CHEMICAL SOC</style></publisher><pub-location><style face="normal" font="default" size="100%">1155 16TH ST, NW, WASHINGTON, DC 20036 USA</style></pub-location><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">318-324</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Self-emulsifying systems are mixtures of oils and surfactants, ideally isotropic, sometimes including cosolvents, which emulsify under conditions of gentle agitation, similar to those which would be encountered in the gastrointestinal tract. The process of self-emulsification has remained the center of attraction for most researchers. Controlled hydration of self-emulsifying systems shows formation of an intermediate gel phase which upon rupture forms an emulsion. Current work was undertaken to understand and explore the microstructural properties of intermediate gel phase which are believed to influence the performance (droplet size) of the final formulation. The effect of additives on microstructural properties of intermediate gel phase has also been investigated. Microstructural elucidation of hydrated samples of intermediate regimes was done by using techniques such as small angle X-ray scattering, differential scanning calorimetry and rheology. Samples from intermediate regimes showed formation of local lamellar structure which swelled with hydration. In the present work, the effect of addition of salt form of naproxen (sodium and potassium) and naproxen (base) on microstructural properties of intermediate regimes was investigated. Systems containing naproxen salts formed larger droplets whereas naproxen base formed smaller ones. Microstructural properties of intermediate lamellar structures were well correlated with performance of the final formulation. The current studies indicate that by controlling the properties of intermediate regimes optimized formulations with desired performance can be tailor-made.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><custom3><style face="normal" font="default" size="100%">Foreign</style></custom3><custom4><style face="normal" font="default" size="100%">4.57
</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Patil, Sharvil S.</style></author><author><style face="normal" font="default" size="100%">Venugopal, Edakkal</style></author><author><style face="normal" font="default" size="100%">Bhat, Suresh K.</style></author><author><style face="normal" font="default" size="100%">Mahadik, Kakasaheb R.</style></author><author><style face="normal" font="default" size="100%">Paradkar, Anant R.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Mapping ion-induced mesophasic transformation in lyotropic in situ gelling system and its correlation with pharmaceutical performance</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmaceutical Research</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">cubic phase</style></keyword><keyword><style  face="normal" font="default" size="100%">hexagonal phase</style></keyword><keyword><style  face="normal" font="default" size="100%">liquid crystal</style></keyword><keyword><style  face="normal" font="default" size="100%">mesophasic transformation</style></keyword><keyword><style  face="normal" font="default" size="100%">sustained drug release</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2013</style></year><pub-dates><date><style  face="normal" font="default" size="100%">JUL</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">7</style></number><publisher><style face="normal" font="default" size="100%">SPRINGER/PLENUM PUBLISHERS</style></publisher><pub-location><style face="normal" font="default" size="100%">233 SPRING ST, NEW YORK, NY 10013 USA</style></pub-location><volume><style face="normal" font="default" size="100%">30</style></volume><pages><style face="normal" font="default" size="100%">1906-1914</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;To investigate influence of ion induced mesophasic transformation on pharmaceutical performance of in situ gelling system consisting of glyceryl monooleate. The prepared system showed mesophasic transformation during its conversion from sol to gel upon controlled hydration. The process of mesophasic transformation was studied by SAXS, DSC, rheology and plane polarized light microscopy. Further the influence of additives i.e. naproxen salts (sodium and potassium) and naproxen (base) on the process of mesophasic transformation was also elucidated. It was observed that addition of salt form of naproxen transformed W/O emulsions into cubic mesophase whereas addition of base form of naproxen formed reverse hexagonal (H-II) phase upon controlled hydration. The cubic mesophase formed by naproxen salts retarded the drug release for initial 3 h whereas H-II phase showed sustained drug release characteristics for naproxen base following Higuchi drug release kinetics. The current work suggests that formulations with tailor made pharmaceutical performance can be developed by selecting proper additives in the system so as to obtain the desired mesophase `on demand' thereby controlling drug release characteristics.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">7</style></issue><custom3><style face="normal" font="default" size="100%">Foreign</style></custom3><custom4><style face="normal" font="default" size="100%">3.952
</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Venugopal, Edakkal</style></author><author><style face="normal" font="default" size="100%">Aswal, Vinod K.</style></author><author><style face="normal" font="default" size="100%">Kumaraswamy, Guruswamy</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Nanoparticle size controls aggregation in lamellar nonionic surfactant mesophase</style></title><secondary-title><style face="normal" font="default" size="100%">Langmuir</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2013</style></year><pub-dates><date><style  face="normal" font="default" size="100%">AUG</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">31</style></number><publisher><style face="normal" font="default" size="100%">AMER CHEMICAL SOC</style></publisher><pub-location><style face="normal" font="default" size="100%">1155 16TH ST, NW, WASHINGTON, DC 20036 USA</style></pub-location><volume><style face="normal" font="default" size="100%">29</style></volume><pages><style face="normal" font="default" size="100%">9643-9650</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;We show that the size of silica nanoparticles influences the nature of their aggregation in an aqueous solution of a relatively hydrophobic nonionic surfactant, C12E4. We present results for dispersions of silica nanopartides with sizes varying from 8 to 26 nm, in a 75: 25 C12E4/water system, that forms a lamellar phase, L-alpha, at room temperature. Addition of silica particles does not affect the formation of the L-alpha phase. Nanoparticles smaller than about 11 nm aggregate irreversibly in the C12E4/water system. However, nanoparticles larger than about 15 nm aggregate in the L-alpha phase, but are dispersed at temperatures above the L-alpha order-disorder temperature. Thus, in contrast to the smaller particles, aggregation of silica nanopartides larger than about 15 nm is reversible with temperature. We use small-angle neutron scattering (SANS) demonstrate that these results can be explained by the size-dependent wrapping of nanoparticles by surfactant bilayers. Larger particles, above 15 nm in size, are sterically stabilized by the formation of an adsorbed surfactant bilayer. The cost of bilayer bending inhibits adsorption onto the highly curved surfaces of smaller particles, and these ``bare'' particles aggregate irreversibly.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">31</style></issue><custom3><style face="normal" font="default" size="100%">Foreign</style></custom3><custom4><style face="normal" font="default" size="100%">3.993</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Deshpande, Sonal</style></author><author><style face="normal" font="default" size="100%">Venugopal, Edakkal</style></author><author><style face="normal" font="default" size="100%">Ramagiri, Shobha</style></author><author><style face="normal" font="default" size="100%">Bellare, Jayesh R.</style></author><author><style face="normal" font="default" size="100%">Kumaraswamy, Guruswamy</style></author><author><style face="normal" font="default" size="100%">Singh, Neetu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Enhancing cubosome functionality by coating with a single layer of poly-epsilon-lysine</style></title><secondary-title><style face="normal" font="default" size="100%">ACS Applied Materials &amp; Interfaces</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">bioconjugation</style></keyword><keyword><style  face="normal" font="default" size="100%">cubosomes</style></keyword><keyword><style  face="normal" font="default" size="100%">drug delivery vehicle</style></keyword><keyword><style  face="normal" font="default" size="100%">dual loading</style></keyword><keyword><style  face="normal" font="default" size="100%">theranostics</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">OCT</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">19</style></number><publisher><style face="normal" font="default" size="100%">AMER CHEMICAL SOC</style></publisher><pub-location><style face="normal" font="default" size="100%">1155 16TH ST, NW, WASHINGTON, DC 20036 USA</style></pub-location><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">17126-17133</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;We report the preparation and characterization of monoolein cubosomes that can be easily surface modified through adsorption of a single layer of cationic poly-epsilon-lysine. Poly-epsilon-lysine coated cubosomes show remarkable stability in serum solution, are nontoxic and, are readily internalized by HeLa cells. The poly-epsilon-lysine coating provides chemical handles for further bioconjugation of the cubosome surface. We also demonstrate that the initial release rate of a hydrophilic drug, Naproxen sodium, from the cubosomes is retarded with just a single layer of polymer. Interestingly, cubosomes loaded with Naproxen sodium, recently shown to have anticancer properties, cause more apoptosis in HeLa cells when compared to free unencapsulated drug.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">19</style></issue><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">&lt;p&gt;Foreign&lt;br&gt;&amp;nbsp;&lt;/p&gt;</style></custom3><custom4><style face="normal" font="default" size="100%">&lt;p&gt;5.76&lt;br&gt;&amp;nbsp;&lt;/p&gt;</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Patil, Sharvil S.</style></author><author><style face="normal" font="default" size="100%">Venugopal, Edakkal</style></author><author><style face="normal" font="default" size="100%">Bhat, Suresh K.</style></author><author><style face="normal" font="default" size="100%">Mahadik, Kakasaheb R.</style></author><author><style face="normal" font="default" size="100%">Paradkar, Anant R.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Exploring microstructural changes in structural analogues of ibuprofen-hosted in situ gelling system and its influence on pharmaceutical performance</style></title><secondary-title><style face="normal" font="default" size="100%">AAPS Pharmscitech</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">flurbiprofen</style></keyword><keyword><style  face="normal" font="default" size="100%">hexagonal phase</style></keyword><keyword><style  face="normal" font="default" size="100%">ibuprofen</style></keyword><keyword><style  face="normal" font="default" size="100%">ketoprofen</style></keyword><keyword><style  face="normal" font="default" size="100%">liquid crystal</style></keyword><keyword><style  face="normal" font="default" size="100%">sustained drug release</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">OCT</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">5</style></number><publisher><style face="normal" font="default" size="100%">SPRINGER</style></publisher><pub-location><style face="normal" font="default" size="100%">233 SPRING ST, NEW YORK, NY 10013 USA</style></pub-location><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1153-1159</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;The present work explores inner structuration of in situ gelling system consisting of glyceryl monooleate (GMO) and oleic acid (OA). The system under study involves investigation of microstructural changes which are believed to govern the pharmaceutical performance of final formulation. The changes which are often termed mesophasic transformation were analysed by small angle Xray scattering (SAXS), differential scanning calorimetry (DSC), rheology and plane polarised light (PPL) microscopy. The current work revealed transformation of blank system from W/O emulsion to reverse hexagonal structure upon addition of structural analogues of ibuprofen. Such transformations are believed to occur due to increased hydrophobic volume within system as probed by SAXS analysis. The findings of SAXS studies were well supported by DSC, rheology and PPL microscopy. The study established inverse relationship between log P value of structural analogues of ibuprofen and the degree of binding of water molecules to surfactant chains. Such relationship had pronounced effect on sol-gel transformation process. The prepared in situ gelling system showed sustained drug release which followed Higuchi model.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><custom3><style face="normal" font="default" size="100%">&lt;p&gt;Foreign&lt;/p&gt;</style></custom3><custom4><style face="normal" font="default" size="100%">1.954</style></custom4></record></records></xml>