<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kumar, S.</style></author><author><style face="normal" font="default" size="100%">Patil, H. S.</style></author><author><style face="normal" font="default" size="100%">Sharma, P.</style></author><author><style face="normal" font="default" size="100%">Kumar, D.</style></author><author><style face="normal" font="default" size="100%">Dasari, Sreekanth</style></author><author><style face="normal" font="default" size="100%">Puranik, Vedavati G.</style></author><author><style face="normal" font="default" size="100%">Thulasiram, H. V.</style></author><author><style face="normal" font="default" size="100%">Kundu, G. C.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Andrographolide inhibits osteopontin expression and breast tumor growth through down regulation of PI3 Kinase/Akt signaling pathway</style></title><secondary-title><style face="normal" font="default" size="100%">Current Molecular Medicine</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Andrographolide</style></keyword><keyword><style  face="normal" font="default" size="100%">angiogenesis and breast tumor</style></keyword><keyword><style  face="normal" font="default" size="100%">migration</style></keyword><keyword><style  face="normal" font="default" size="100%">osteopontin</style></keyword><keyword><style  face="normal" font="default" size="100%">PI 3 kinase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2012</style></year><pub-dates><date><style  face="normal" font="default" size="100%">SEP</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">8</style></number><publisher><style face="normal" font="default" size="100%">BENTHAM SCIENCE PUBL LTD</style></publisher><pub-location><style face="normal" font="default" size="100%">EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES</style></pub-location><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">952-966</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Breast cancer is one of the most common cancers among women in India and around the world. Despite recent advancement in the treatment of breast cancer, the results of chemotherapy to date remain unsatisfactory, prompting a need to identify natural agents that could target cancer efficiently with least side effects. Andrographolide (Andro) is one such molecule which has been shown to possess inhibitory effect on cancer cell growth. In this study, Andro, a natural diterpenoid lactone isolated from Andrographis paniculata has been shown to inhibit breast cancer cell proliferation, migration and arrest cell cycle at G2/M phase and induces apoptosis through caspase independent pathway. Our experimental evidences suggest that Andro attenuates endothelial cell motility and tumor-endothelial cell interaction. Moreover, Andro suppresses breast tumor growth in orthotopic NOD/SCID mice model. The anti-tumor activity of Andro in both in vitro and in vivo model was correlated with down regulation of PI3 kinase/Akt activation and inhibition of pro-angiogenic molecules such as OPN and VEGF expressions. Collectively, these results demonstrate that Andro may act as an effective anti-tumor and anti-angiogenic agent for the treatment of breast cancer.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">8</style></issue><custom3><style face="normal" font="default" size="100%">&lt;p&gt;Foreign&lt;/p&gt;</style></custom3><custom4><style face="normal" font="default" size="100%">&lt;p&gt;4.197&lt;/p&gt;</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gaur, A. S.</style></author><author><style face="normal" font="default" size="100%">Bhardwaj, A.</style></author><author><style face="normal" font="default" size="100%">Sharma, A.</style></author><author><style face="normal" font="default" size="100%">John, L.</style></author><author><style face="normal" font="default" size="100%">Vivek, M. R.</style></author><author><style face="normal" font="default" size="100%">Tripathi, N.</style></author><author><style face="normal" font="default" size="100%">Bharatam, P. V.</style></author><author><style face="normal" font="default" size="100%">Kumar, R.</style></author><author><style face="normal" font="default" size="100%">Janardhan, S.</style></author><author><style face="normal" font="default" size="100%">Mori, A.</style></author><author><style face="normal" font="default" size="100%">Banerji, A.</style></author><author><style face="normal" font="default" size="100%">Lynn, A. M.</style></author><author><style face="normal" font="default" size="100%">Hemrom, A. J.</style></author><author><style face="normal" font="default" size="100%">Passi, A.</style></author><author><style face="normal" font="default" size="100%">Singh, A.</style></author><author><style face="normal" font="default" size="100%">Kumar, A.</style></author><author><style face="normal" font="default" size="100%">Muvva, C.</style></author><author><style face="normal" font="default" size="100%">Madhuri, C.</style></author><author><style face="normal" font="default" size="100%">Choudhury, C.</style></author><author><style face="normal" font="default" size="100%">Kumar, D. A.</style></author><author><style face="normal" font="default" size="100%">Pandit, D.</style></author><author><style face="normal" font="default" size="100%">Bharti, D. R.</style></author><author><style face="normal" font="default" size="100%">Kumar, D.</style></author><author><style face="normal" font="default" size="100%">Singam, E. A.</style></author><author><style face="normal" font="default" size="100%">Raghava, G. P.</style></author><author><style face="normal" font="default" size="100%">Sailaja, H.</style></author><author><style face="normal" font="default" size="100%">Jangra, H.</style></author><author><style face="normal" font="default" size="100%">Raithatha, K.</style></author><author><style face="normal" font="default" size="100%">Tanneeru, K.</style></author><author><style face="normal" font="default" size="100%">Chaudhary, K.</style></author><author><style face="normal" font="default" size="100%">Karthikeyan, M.</style></author><author><style face="normal" font="default" size="100%">Prasanthi, M.</style></author><author><style face="normal" font="default" size="100%">Kumar, N.</style></author><author><style face="normal" font="default" size="100%">Yedukondalu, N.</style></author><author><style face="normal" font="default" size="100%">Rajput, N. K.</style></author><author><style face="normal" font="default" size="100%">Saranya, P. S.</style></author><author><style face="normal" font="default" size="100%">Narang, P.</style></author><author><style face="normal" font="default" size="100%">Dutta, Prantu</style></author><author><style face="normal" font="default" size="100%">Krishnan, R.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Assessing therapeutic potential of molecules: molecular property diagnostic suite for tuberculosis</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Chemical Sciences</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">chemical analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Chemoinformatics</style></keyword><keyword><style  face="normal" font="default" size="100%">computational chemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Diagnosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Drug discovery portal</style></keyword><keyword><style  face="normal" font="default" size="100%">Information analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Libraries</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular graphics</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecules</style></keyword><keyword><style  face="normal" font="default" size="100%">Neglected diseases</style></keyword><keyword><style  face="normal" font="default" size="100%">Open science</style></keyword><keyword><style  face="normal" font="default" size="100%">Portals</style></keyword><keyword><style  face="normal" font="default" size="100%">tuberculosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Web-based technology</style></keyword><keyword><style  face="normal" font="default" size="100%">Websites</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">MAY</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">129</style></volume><pages><style face="normal" font="default" size="100%">515-531</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Abstract: Molecular Property Diagnostic Suite (MPDS TB) is a web tool (http://mpds.osdd.net) designed to assist the in silico drug discovery attempts towards Mycobacterium tuberculosis (Mtb). MPDS TB tool has nine modules which are classified into data library (1–3), data processing (4–5) and data analysis (6–9). Module 1 is a repository of literature and related information available on the Mtb. Module 2 deals with the protein target analysis of the chosen disease area. Module 3 is the compound library consisting of 110.31 million unique molecules generated from public domain databases and custom designed search tools. Module 4 contains tools for chemical file format conversions and 2D to 3D coordinate conversions. Module 5 helps in calculating the molecular descriptors. Module 6 specifically handles QSAR model development tools using descriptors generated in the Module 5. Module 7 integrates the AutoDock Vina algorithm for docking, while module 8 provides screening filters. Module 9 provides the necessary visualization tools for both small and large molecules. The workflow-based open source web portal, MPDS TB 1.0.1 can be a potential enabler for scientists engaged in drug discovery in general and in anti-TB research in particular. Graphical Abstract: SYNOPSIS: A web-based MPDS TB Galaxy tool is developed for assessing therapeutic potential of molecules. MPDS TB is categorized into Data Library, Data Processing and Data Analysis. It can be a potential enabler for scientists engaged in drug discovery in general and in anti-TB research in particular. [Figure not available: see fulltext.] © 2017, Indian Academy of Sciences.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">Indian</style></custom3><custom4><style face="normal" font="default" size="100%">1.254</style></custom4></record></records></xml>