<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Singh, Bhuvnesh</style></author><author><style face="normal" font="default" size="100%">Tewari, Shreya</style></author><author><style face="normal" font="default" size="100%">Kaur, Manleen</style></author><author><style face="normal" font="default" size="100%">Sharma, Himanshu</style></author><author><style face="normal" font="default" size="100%">Vanka, Kumar</style></author><author><style face="normal" font="default" size="100%">Singh, Neetu</style></author><author><style face="normal" font="default" size="100%">Singh, Ravi P.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Bioinspired synthesis of bridged isochromane fused pyrazoles by a silver catalyzed cascade reaction and its application for antibacterial activity</style></title><secondary-title><style face="normal" font="default" size="100%">JACS Au</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Bridged [2.2.2] [3.3.1]</style></keyword><keyword><style  face="normal" font="default" size="100%">ROS</style></keyword><keyword><style  face="normal" font="default" size="100%">Stereoselective</style></keyword><keyword><style  face="normal" font="default" size="100%">Vinylogous aldol addition</style></keyword><keyword><style  face="normal" font="default" size="100%">[4+2] cycloaddition</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">AUG</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">5</style></volume><pages><style face="normal" font="default" size="100%">4184–4195</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;
	&lt;span style=&quot;color: rgb(21, 21, 21); font-family: Roboto, arial, sans-serif; font-size: 16px;&quot;&gt;A stereoselective silver catalyzed one pot vinylogous aldol addition followed by a cascade [4+2] cycloaddition reaction of α-arylidene pyrazolinones to&amp;nbsp;&lt;/span&gt;&lt;i style=&quot;box-sizing: border-box; outline: none; color: rgb(21, 21, 21); font-family: Roboto, arial, sans-serif; font-size: 16px;&quot;&gt;in situ&lt;/i&gt;&lt;span style=&quot;color: rgb(21, 21, 21); font-family: Roboto, arial, sans-serif; font-size: 16px;&quot;&gt;&amp;nbsp;generated isochromenylium ions has been developed, which provides an unprecedented bridged [2.2.2] [3.3.1] pentacyclic [5-6-6-6-6] skeleton consisting of an isochroman, chroman, and a pyrazole unit in one molecule with good to high yields as a single diastereomer. This method offers mild reaction conditions, wide substrate compatibility, excellent scalability and easy derivatization. A DFT study was carried out to clarify the reaction mechanism. It was exciting to observe that the unprecedented bridged isochromans synthesized here have shown excellent selectivity toward Gram-positive and Gram-negative bacteria. We demonstrate that while some structures are broad spectrum antibacterial there are two distinct structures that can be explored for selective activity.&lt;/span&gt;&lt;/p&gt;
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	Foreign&lt;/p&gt;
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	9.2&lt;/p&gt;
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