<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kadam, Mayur</style></author><author><style face="normal" font="default" size="100%">Jadhao, Nitin L.</style></author><author><style face="normal" font="default" size="100%">Gajbhiye, Jayant M.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Synthesis of pyrazole and 1,3,4-oxadiazole derivatives of pharmaceutical potential</style></title><secondary-title><style face="normal" font="default" size="100%">Prospects in Pharmaceutical Sciences</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Aug</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://prospects.wum.edu.pl/index.php/pps/article/view/235</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">22</style></volume><pages><style face="normal" font="default" size="100%">127–135</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;
	&lt;span style=&quot;color: rgb(33, 37, 41); font-family: Lato, sans-serif; font-size: 14px;&quot;&gt;Heterocyclic compounds are important molecules that serve as scaffolds or linkers for the core structure of numerous drug substances. In particular, pyrazole and 1,3,4-oxadiazole are compounds of great interest due to their comprehensive biological activities and interesting structural features. Here, we described an efficient and economical synthetic route leading to&amp;nbsp;&lt;/span&gt;&lt;em style=&quot;box-sizing: border-box; color: rgb(33, 37, 41); font-family: Lato, sans-serif; font-size: 14px;&quot;&gt;N&lt;/em&gt;&lt;span style=&quot;color: rgb(33, 37, 41); font-family: Lato, sans-serif; font-size: 14px;&quot;&gt;-phenyl substituted pyrazole and 1,3,4-oxadiazole derivatives. Retrosynthetic disconnective analysis showed that the&amp;nbsp;&lt;/span&gt;&lt;em style=&quot;box-sizing: border-box; color: rgb(33, 37, 41); font-family: Lato, sans-serif; font-size: 14px;&quot;&gt;N&lt;/em&gt;&lt;span style=&quot;color: rgb(33, 37, 41); font-family: Lato, sans-serif; font-size: 14px;&quot;&gt;-phenyl substituted pyrazole can be obtained from chalcone, accessible from the respective aldehyde, and acetophenone. The disubstituted 1,3,4-oxadiazole can be constructed from the respective aldehyde, which originates from pyrrole-containing compound, and formyl chloride. Based on our retrosynthetic analysis,&amp;nbsp;&lt;/span&gt;&lt;em style=&quot;box-sizing: border-box; color: rgb(33, 37, 41); font-family: Lato, sans-serif; font-size: 14px;&quot;&gt;N&lt;/em&gt;&lt;span style=&quot;color: rgb(33, 37, 41); font-family: Lato, sans-serif; font-size: 14px;&quot;&gt;-phenyl substituted pyrazole was obtained by cyclization of the respective chalcone with phenylhydrazine to give pyrazoline which was in turn converted into pyrazole by oxidative aromatization. Potassium carbonate and a catalytic amount of molecular iodine were used to oxidatively cyclize semicarbazones into 1,3,4-oxadiazoles in a transition metal-free process. Novel pyrazole and 1,3,4-oxadiazoles with potential biological activity are investigated as antituberculosis, anticonvulsant, antidiabetic, anticancer, and tyrosinase inhibitory agents.&lt;/span&gt;&lt;/p&gt;
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	Foreign&lt;/p&gt;
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	0.1&lt;/p&gt;
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