<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Darole, Ratanamala S.</style></author><author><style face="normal" font="default" size="100%">Bagad, Pooja K.</style></author><author><style face="normal" font="default" size="100%">Gonnade, Rajesh G.</style></author><author><style face="normal" font="default" size="100%">Alagarasu, Kalichamy</style></author><author><style face="normal" font="default" size="100%">Punekar, Madhura</style></author><author><style face="normal" font="default" size="100%">Shukla, Shridhar</style></author><author><style face="normal" font="default" size="100%">Parashar, Deepti</style></author><author><style face="normal" font="default" size="100%">Senthilkumar, Beeran</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Synthesis of novel rhodamine type anthrone Spiro-lactam (ASL) analogues and evaluation of antiviral activity against dengue and chikungunya viruses</style></title><secondary-title><style face="normal" font="default" size="100%">European Journal of Medicinal Chemistry </style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anthrone Spiro-lactam</style></keyword><keyword><style  face="normal" font="default" size="100%">Chikungunya virus</style></keyword><keyword><style  face="normal" font="default" size="100%">dengue virus</style></keyword><keyword><style  face="normal" font="default" size="100%">Rhodamine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">DEC </style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">261</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;
	A series of Rhodamine type Anthrone-Spirolactam (ASL) derivatives Benzylimin-Anthrone-Spirolactam (ASL-1 to ASL-10) and Benzamide-Anthrone-Spirolactam (ASL-11 and ASL-12) were synthesized via a simple condensation reaction between Anthrone Spiro-lactamine (2) and various aromatic aldehyde and acyl chlorides respectively. Since rhodamine-based compounds were reported to have antiviral activity, the ASL derivatives were examined for in vitro antiviral activity against dengue and chikungunya viruses. Among all the analogues, ASL-3, ASL-6, ASL-7, ASL-8, ASL-9 and ASL-10 were the most potent against dengue virus (DENV) and exerted around one log reduction in virus titre under post -treatment conditions. At the same time ASL-3 was effective under cotreatment conditions. Two analogues ASL-6 and ASL-12 exerted anti-chikungunya virus (CHIKV) activity under post -treatment conditions. In silico docking studies revealed that the ASL derivatives interacted with the proteins of DENV and CHIKV. Together, the results suggest the anti-DENV and CHIKV activity of ASL derivatives which may be exploited further for therapeutic purposes.&lt;/p&gt;
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	Foreign&lt;/p&gt;
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	6.7&lt;/p&gt;
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