<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kulkarni-Dwivedi, Neha</style></author><author><style face="normal" font="default" size="100%">Patel, Pratikshkumar R.</style></author><author><style face="normal" font="default" size="100%">Shravage, V. Bhupendra</style></author><author><style face="normal" font="default" size="100%">Umrani, Rinku D.</style></author><author><style face="normal" font="default" size="100%">Paknikar, Kishore M.</style></author><author><style face="normal" font="default" size="100%">Jadhav, Sachin H.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hyperthermia and doxorubicin release by Fol-LSMO nanoparticles induce apoptosis and autophagy in breast cancer cells</style></title><secondary-title><style face="normal" font="default" size="100%">Nanomedicine</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Apoptosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Autophagy</style></keyword><keyword><style  face="normal" font="default" size="100%">Breast cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">combination therapy</style></keyword><keyword><style  face="normal" font="default" size="100%">doxorubicin</style></keyword><keyword><style  face="normal" font="default" size="100%">Folic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">hyperthermia</style></keyword><keyword><style  face="normal" font="default" size="100%">LSMO</style></keyword><keyword><style  face="normal" font="default" size="100%">MDA-MB231 cells</style></keyword><keyword><style  face="normal" font="default" size="100%">PEG</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">OCT</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">1929-1949</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;
	Background: Studies on the anticancer effects of lanthanum strontium manganese oxide (LSMO) nanoparticles (NPs)-mediated hyperthermia at cellular and molecular levels are scarce. Materials &amp;amp; methods: LSMO NPs conjugated with folic acid (Fol-LSMO NPs) were synthesized, followed by doxorubicin-loading (DoxFol-LSMO NPs), and their effects on breast cancer cells were investigated. Results: Hyperthermia (45 degrees C) and combination treatments exhibited the highest (similar to 95%) anticancer activity with increased oxidative stress. The involvement of intrinsic mitochondria-mediated apoptotic pathway and induction of autophagy was noted. Cellular and molecular evidence confirmed the crosstalk between apoptosis and autophagy, involving Beclin1, Bcl2 and Caspase-3 genes with free reactive oxygen species presence. Conclusion: The study confirmed hyperthermia and doxorubicin release by Fol-LSMO NPs induces apoptosis and autophagy in breast cancer cells.&lt;/p&gt;
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