<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kadam, Mayur</style></author><author><style face="normal" font="default" size="100%">Jadhao, Nitin L.</style></author><author><style face="normal" font="default" size="100%">Gajbhiye, Jayant M.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Synthesis of pyrazole and 1,3,4-oxadiazole derivatives of pharmaceutical potential</style></title><secondary-title><style face="normal" font="default" size="100%">Prospects in Pharmaceutical Sciences</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Aug</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">https://prospects.wum.edu.pl/index.php/pps/article/view/235</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">22</style></volume><pages><style face="normal" font="default" size="100%">127–135</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;
	&lt;span style=&quot;color: rgb(33, 37, 41); font-family: Lato, sans-serif; font-size: 14px;&quot;&gt;Heterocyclic compounds are important molecules that serve as scaffolds or linkers for the core structure of numerous drug substances. In particular, pyrazole and 1,3,4-oxadiazole are compounds of great interest due to their comprehensive biological activities and interesting structural features. Here, we described an efficient and economical synthetic route leading to&amp;nbsp;&lt;/span&gt;&lt;em style=&quot;box-sizing: border-box; color: rgb(33, 37, 41); font-family: Lato, sans-serif; font-size: 14px;&quot;&gt;N&lt;/em&gt;&lt;span style=&quot;color: rgb(33, 37, 41); font-family: Lato, sans-serif; font-size: 14px;&quot;&gt;-phenyl substituted pyrazole and 1,3,4-oxadiazole derivatives. Retrosynthetic disconnective analysis showed that the&amp;nbsp;&lt;/span&gt;&lt;em style=&quot;box-sizing: border-box; color: rgb(33, 37, 41); font-family: Lato, sans-serif; font-size: 14px;&quot;&gt;N&lt;/em&gt;&lt;span style=&quot;color: rgb(33, 37, 41); font-family: Lato, sans-serif; font-size: 14px;&quot;&gt;-phenyl substituted pyrazole can be obtained from chalcone, accessible from the respective aldehyde, and acetophenone. The disubstituted 1,3,4-oxadiazole can be constructed from the respective aldehyde, which originates from pyrrole-containing compound, and formyl chloride. Based on our retrosynthetic analysis,&amp;nbsp;&lt;/span&gt;&lt;em style=&quot;box-sizing: border-box; color: rgb(33, 37, 41); font-family: Lato, sans-serif; font-size: 14px;&quot;&gt;N&lt;/em&gt;&lt;span style=&quot;color: rgb(33, 37, 41); font-family: Lato, sans-serif; font-size: 14px;&quot;&gt;-phenyl substituted pyrazole was obtained by cyclization of the respective chalcone with phenylhydrazine to give pyrazoline which was in turn converted into pyrazole by oxidative aromatization. Potassium carbonate and a catalytic amount of molecular iodine were used to oxidatively cyclize semicarbazones into 1,3,4-oxadiazoles in a transition metal-free process. Novel pyrazole and 1,3,4-oxadiazoles with potential biological activity are investigated as antituberculosis, anticonvulsant, antidiabetic, anticancer, and tyrosinase inhibitory agents.&lt;/span&gt;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><custom3><style face="normal" font="default" size="100%">&lt;p&gt;
	Foreign&lt;/p&gt;
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	0.1&lt;/p&gt;
</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gedam, Ashwin D.</style></author><author><style face="normal" font="default" size="100%">Katiya, Manish M.</style></author><author><style face="normal" font="default" size="100%">Dhonde, Madhukar G.</style></author><author><style face="normal" font="default" size="100%">Ganorkar, Kapil S.</style></author><author><style face="normal" font="default" size="100%">Thakare, Vijay J.</style></author><author><style face="normal" font="default" size="100%">Mandlik, Prashant R.</style></author><author><style face="normal" font="default" size="100%">Jadhao, Nitin L.</style></author><author><style face="normal" font="default" size="100%">Gajbhiye, Jayant M.</style></author><author><style face="normal" font="default" size="100%">Kumar, Ravi</style></author><author><style face="normal" font="default" size="100%">Vaval, Nayana</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Synthesized novel chromogenic reagent and sensor: detection and identification of dichlorvos</style></title><secondary-title><style face="normal" font="default" size="100%">Heliyon</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">DFT analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Dichlorvos</style></keyword><keyword><style  face="normal" font="default" size="100%">Gloyxal</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydrazone</style></keyword><keyword><style  face="normal" font="default" size="100%">Isoniazid</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">MAY</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">e31217</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;
	We developed a novel chromogenic reagent and sensor by selective approach, for the detection and identification of dichlorvos, which we tested with the thin layer chromatography method. For the first time, we reported in situ-generated glyoxal as a hydrolysis product, which then interacts with isoniazid to produce a yellow-colored cyclic compound. We used well-known spectroscopic techniques to confirm the chemical identity of the final product. We initially investigated the reaction using a variety of approaches, followed by attempts to establish the reaction mechanism using Density Functional Theory by Gaussian software.&lt;/p&gt;
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	Foreign&lt;/p&gt;
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	4&lt;/p&gt;
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