<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Padhye, Preeti</style></author><author><style face="normal" font="default" size="100%">Alam, Aftab</style></author><author><style face="normal" font="default" size="100%">Ghorai, Suvankar</style></author><author><style face="normal" font="default" size="100%">Chattopadhyay, Sarnit</style></author><author><style face="normal" font="default" size="100%">Poddar, Pankaj</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Doxorubicin-conjugated beta-NaYF4:Gd3+/Tb3+ multifunctional, phosphor nanorods: a multimodal, luminescent, magnetic probe for simultaneous optical and magnetic resonance imaging and an excellent pH-triggered anti-cancer drug delivery nanovehicle</style></title><secondary-title><style face="normal" font="default" size="100%">Nanoscale</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">OCT</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">46</style></number><publisher><style face="normal" font="default" size="100%">ROYAL SOC CHEMISTRY</style></publisher><pub-location><style face="normal" font="default" size="100%">THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND</style></pub-location><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">19501-19518</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Herein, we report the fabrication of a multifunctional nanoprobe based on highly monodispersed, optically and magnetically active, biocompatible, PEI-functionalized, highly crystalline beta-NaYF4:Gd3+/Tb3+ nanorods as an excellent multi-modal optical/magnetic imaging tool and a pH-triggered intracellular drug delivery nanovehicle. The static and dynamic photoluminescence spectroscopy showed the presence of sharp emission peaks, with long lifetimes (similar to 3.5 milliseconds), suitable for optical imaging. The static magnetic susceptibility measurements at room temperature showed a strong paramagnetic signal (chi similar to 3.8 x 10(-5) emu g(-1) Oe(-1)). The nuclear magnetic resonance (NMR) measurements showed fair T-1 relaxivity (r(1) = 1.14 s(-1) mM(-1)) and magnetic resonance imaging gave enhanced T-1-weighted MRI images with increased concentrations of beta-NaYF4:Gd3+/Tb3+ making them suitable for simultaneous magnetic resonance imaging. In addition, an anticancer drug, doxorubicin (DOX) was conjugated to the amine-functionalized beta-NaYF4:Gd3+/Tb3+ nanorods via pH-sensitive hydrazone bond linkages enabling them as a pH-triggered, site-specific drug delivery nanovehicle for DOX release inside tumor cells. A comparison between in vitro DOX release studies undertaken in normal physiological (pH 7.4) and acidic (pH 5.0) environments showed an enhanced DOX dissociation (similar to 80%) at pH 5.0. The multifunctional material was also applied as an optical probe to confirm the conjugation of DOX and to monitor DOX release via a fluorescence resonance energy transfer (FRET) mechanism. The DOX-conjugated beta-NaYF4:Gd3+/Tb3+ nanorods exhibited a cytotoxic effect on MCF-7 breast cancer cells and their uptake by MCF-7 cells was demonstrated using confocal laser scanning microscopy and flow cytometry. The comparative cellular uptakes of free DOX and DOX-conjugated beta-NaYF4:Gd3+/Tb3+ nanorods were studied in tumor microenvironment conditions (pH 6.5) using confocal imaging, which showed an increased uptake of DOX-conjugated beta-NaYF4:Gd3+/Tb3+ nanorods. Thus, DOX-conjugated beta-NaYF4:Get(3+)/Tb3+ nanorods combining pH-triggered drug delivery, efficient luminescence and paramagnetic properties are promising for a potential multifunctional platform for cancer therapy, biodetection, and optical and magnetic resonance imaging.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">46</style></issue><custom3><style face="normal" font="default" size="100%">&lt;p&gt;Foreign&lt;/p&gt;</style></custom3><custom4><style face="normal" font="default" size="100%">7.76</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Malik, Monika</style></author><author><style face="normal" font="default" size="100%">Padhye, Preeti</style></author><author><style face="normal" font="default" size="100%">Poddar, Pankaj</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%"> Downconversion luminescence-based nanosensor for label-free detection of explosives </style></title><secondary-title><style face="normal" font="default" size="100%">Acs Omega</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">FEB</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">4</style></volume><pages><style face="normal" font="default" size="100%">4259-4268</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;We report &lt;span class=&quot;hitHilite&quot;&gt;a&lt;/span&gt; selective and sensitive &lt;span class=&quot;hitHilite&quot;&gt;nanosensor&lt;/span&gt; probe based on polyethylenimine (PEI)-capped downconverting nanophosphors beta-NaYF4:Gd3+, Tb3+@PEI &lt;span class=&quot;hitHilite&quot;&gt;for&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;detection&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;of&lt;/span&gt; 2,4,6-trinitrotoluene (TNT), &lt;span class=&quot;hitHilite&quot;&gt;both&lt;/span&gt; in water and buffer media. These downconverting phosphors were synthesized via &lt;span class=&quot;hitHilite&quot;&gt;a&lt;/span&gt; hydrothermal route and are known to show excellent chemical, thermal, and photostability. They emit sharp emission peaks centered at similar to 488, 544, 584, and 619 nm, among which &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; peak at similar to 544 nm was remarkably quenched (similar to 90%) &lt;span class=&quot;hitHilite&quot;&gt;by&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; addition &lt;span class=&quot;hitHilite&quot;&gt;of&lt;/span&gt; TNT without giving any new emission peak. &lt;span class=&quot;hitHilite&quot;&gt;The&lt;/span&gt; sensing mechanism is based on &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;formation&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;of&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;a&lt;/span&gt; Meisenheimer &lt;span class=&quot;hitHilite&quot;&gt;complex&lt;/span&gt; between &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;electron&lt;/span&gt;-rich amine-functionalized beta-NaYF4:Gd3+, Tb3+ nanophosphors and &lt;span class=&quot;hitHilite&quot;&gt;electron&lt;/span&gt;-deficient TNT molecule, which was prominently visualized &lt;span class=&quot;hitHilite&quot;&gt;by&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; change in &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; color &lt;span class=&quot;hitHilite&quot;&gt;of&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; solution &lt;span class=&quot;hitHilite&quot;&gt;from&lt;/span&gt; whitish to brownish yellow, enabling visual &lt;span class=&quot;hitHilite&quot;&gt;detection&lt;/span&gt;, followed &lt;span class=&quot;hitHilite&quot;&gt;by&lt;/span&gt; luminescence resonance energy &lt;span class=&quot;hitHilite&quot;&gt;transfer&lt;/span&gt; between &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; nanophosphors and &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;complex&lt;/span&gt;. &lt;span class=&quot;hitHilite&quot;&gt;A&lt;/span&gt; linear range &lt;span class=&quot;hitHilite&quot;&gt;for&lt;/span&gt; TNT &lt;span class=&quot;hitHilite&quot;&gt;detection&lt;/span&gt; was obtained &lt;span class=&quot;hitHilite&quot;&gt;from&lt;/span&gt; 0.1 to 300 mu M &lt;span class=&quot;hitHilite&quot;&gt;with&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;a&lt;/span&gt; limit &lt;span class=&quot;hitHilite&quot;&gt;of&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;detection&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;as&lt;/span&gt; low &lt;span class=&quot;hitHilite&quot;&gt;as&lt;/span&gt; 119.9 nM. This method displayed excellent selectivity toward TNT over other nitroaromatic compounds, which had no influence on &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;detection&lt;/span&gt;. Moreover, various other classes &lt;span class=&quot;hitHilite&quot;&gt;of&lt;/span&gt; analytes, viz., amino acids, pesticides, and sugars, did not quench &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; luminescence intensity &lt;span class=&quot;hitHilite&quot;&gt;of&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; nanophosphors. This developed &lt;span class=&quot;hitHilite&quot;&gt;nanosensor&lt;/span&gt; probe possesses high, stable fluorescence brightness and capability &lt;span class=&quot;hitHilite&quot;&gt;for&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; selective and sensitive on-site recognition &lt;span class=&quot;hitHilite&quot;&gt;of&lt;/span&gt; TNT molecules in aqueous media, avoiding complicated strategies and instruments. Thus, this work promises to pave ways to many applications in &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;detection&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;of&lt;/span&gt; ultratrace analytes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">&lt;p&gt;Foreign&lt;/p&gt;
</style></custom3><custom4><style face="normal" font="default" size="100%">&lt;p&gt;&lt;span class=&quot;jhHeader_impact&quot;&gt;2.584&lt;/span&gt;&lt;/p&gt;
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