<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>5</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Manikkam, Radhakrishnan</style></author><author><style face="normal" font="default" size="100%">Pati, Premalata</style></author><author><style face="normal" font="default" size="100%">Thangavel, Shanmugasundaram</style></author><author><style face="normal" font="default" size="100%">Venugopal, Gopikrishnan</style></author><author><style face="normal" font="default" size="100%">Joseph, Jerrine</style></author><author><style face="normal" font="default" size="100%">Ramasamy, Balagurunathan</style></author><author><style face="normal" font="default" size="100%">Dastager, Syed G.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Distribution and bioprospecting potential of actinobacteria from Indian mangrove ecosystems</style></title><secondary-title><style face="normal" font="default" size="100%">Microbial Diversity in Ecosystem Sustainability and Biotechnological Applications</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2019</style></year></dates><publisher><style face="normal" font="default" size="100%">Springer, Singapore</style></publisher><pages><style face="normal" font="default" size="100%">319-353</style></pages><isbn><style face="normal" font="default" size="100%">978-981-13-8315-1</style></isbn><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Actinobacteria are the ecologically and economically important prokaryotes with the unprecedented ability to produce novel metabolites. They are widely distributed in nature due to their physiological and metabolic versatility. Actinobacteria from marine ecosystem are recognized as a promising source for novel bioactive metabolites. Notably, mangroves are the most fertile and productive marine ecosystem due to their ecophysiological conditions and vast microbial diversity. At the global level, there are many novel actinobacteria which have been reported from mangrove ecosystems and also explored for their bioprospecting potential. However, in India, microbiologists have explored actinobacteria from selected mangrove ecosystems for the past five decades with special reference to culturable diversity and antimicrobial, antimycobacterial, anticancer, and enzymatic activities. So far, around 22 rare actinobacterial genera have been reported from the Indian mangrove ecosystems. However, several other novel actinobacteria with promising bioprospecting potential are yet to be explored. Hence, research on actinobacteria in the Indian mangrove ecosystem is still in its infancy. This chapter will describe the exploratory research work carried out on the importance, diversity, antimicrobial and enzymatic activity, biodegradation, and nanotechnological potency of actinobacteria from the Indian mangrove ecosystems. This chapter will enable researchers to identify the gaps to be bridged for further research on Indian mangrove actinobacteria and exploit their potential to the maximum benefit to mankind.</style></abstract><custom3><style face="normal" font="default" size="100%">Foreign</style></custom3><custom4><style face="normal" font="default" size="100%">NA</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kaari, Manigundan</style></author><author><style face="normal" font="default" size="100%">Joseph, Jerrine</style></author><author><style face="normal" font="default" size="100%">Manikkam, Radhakrishnan</style></author><author><style face="normal" font="default" size="100%">Kalyanasundaram, Revathy</style></author><author><style face="normal" font="default" size="100%">Sivaraj, Anbarasu</style></author><author><style face="normal" font="default" size="100%">Anbalmani, Sivarajan</style></author><author><style face="normal" font="default" size="100%">Murthy, Sangeetha</style></author><author><style face="normal" font="default" size="100%">Sahu, Amit Kumar</style></author><author><style face="normal" font="default" size="100%">Said, Madhukar</style></author><author><style face="normal" font="default" size="100%">Dastager, Syed G.</style></author><author><style face="normal" font="default" size="100%">Ramasamy, Balagurunathan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Novel finding: 2,4-Di-tert-butylphenol from streptomyces bacillaris ANS2 effective against mycobacterium tuberculosis and cancer cell lines</style></title><secondary-title><style face="normal" font="default" size="100%">Applied Biochemistry and Biotechnology </style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">2</style></keyword><keyword><style  face="normal" font="default" size="100%">4-Di-tert-butylphenol</style></keyword><keyword><style  face="normal" font="default" size="100%">anti-cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-tubercular</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking</style></keyword><keyword><style  face="normal" font="default" size="100%">Streptomyces bacillaris</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">NOV</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">195</style></volume><pages><style face="normal" font="default" size="100%">6572-6585</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;
	The aim of the present study is to identify actinobacteria Streptomyces bacillaris ANS2 as the source of the potentially beneficial compound 2,4-di-tert-butylphenol, describe its chemical components, and assess its anti-tubercular (TB) and anti-cancer properties. Ethyl acetate was used in the agar surface fermentation of S. bacillaris ANS2 to produce the bioactive metabolites. Using various chromatographic and spectroscopy analyses, the potential bioactive metabolite separated and identified as 2,4-di-tert-butylphenol (2,4-DTBP). The lead compound 2,4-DTBP inhibited 78% and 74% of relative light unit (RLU) decrease against MDR Mycobacterium tuberculosis at 100ug/ml and 50ug/ml concentrations, respectively. The Wayne model was used to assess the latent/dormant potential in M. tuberculosis H37RV at various doses, and the MIC for the isolated molecule was found to be 100ug/ml. Furthermore, the molecular docking of 2,4-DTBP was docked using Autodock Vinasuite onto the substrate binding site of the target Mycobacterium lysine aminotransferase (LAT) and the grid box was configured for the docking run to cover the whole LAT dimer interface. At a dosage of 1 mg/ml, the anti-cancer activity of the compound 2,4-DTBP was 88% and 89% inhibited against the HT 29 (colon cancer) and HeLa (cervical cancer) cell lines. According to our literature survey, this present finding may be the first report on anti-TB activity of 2,4-DTBP and has the potential to become an effective natural source and the promising pharmaceutical drug in the future.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">11</style></issue><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">&lt;p&gt;
	Foreign&lt;/p&gt;
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</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kaari, Manigundan</style></author><author><style face="normal" font="default" size="100%">Manikkam, Radhakrishnan</style></author><author><style face="normal" font="default" size="100%">Joseph, Jerrine</style></author><author><style face="normal" font="default" size="100%">Krishnan, Sakthivel</style></author><author><style face="normal" font="default" size="100%">Annamalai, Kishore Kumar</style></author><author><style face="normal" font="default" size="100%">Khan, Abujunaid</style></author><author><style face="normal" font="default" size="100%">Rajput, Vinay</style></author><author><style face="normal" font="default" size="100%">Dastager, Syed Gulam</style></author><author><style face="normal" font="default" size="100%">Dharne, Mahesh S.</style></author><author><style face="normal" font="default" size="100%">Umar, Md</style></author><author><style face="normal" font="default" size="100%">Venugopal, Gopikrishnan</style></author><author><style face="normal" font="default" size="100%">Alexander, Balamurugan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Integrated genomic and functional analysis of Streptomyces sp. UP1A-1 for bacterial wilt control and solanaceae yield increase</style></title><secondary-title><style face="normal" font="default" size="100%">Gene Reports</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">DEC</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">37</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;
	&lt;em style=&quot;box-sizing: border-box; margin: 0px; padding: 0px; color: rgb(31, 31, 31); font-family: ElsevierGulliver, Georgia, &amp;quot;Times New Roman&amp;quot;, Times, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif, sans-serif; font-size: 16px;&quot;&gt;Ralstonia solanacearum&lt;/em&gt;&lt;span style=&quot;color: rgb(31, 31, 31); font-family: ElsevierGulliver, Georgia, &amp;quot;Times New Roman&amp;quot;, Times, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif, sans-serif; font-size: 16px;&quot;&gt;&amp;nbsp;is one of the most destructive soil-borne pathogen, causing bacterial wilt to the solanaceae vegetables.&amp;nbsp;&lt;/span&gt;&lt;em style=&quot;box-sizing: border-box; margin: 0px; padding: 0px; color: rgb(31, 31, 31); font-family: ElsevierGulliver, Georgia, &amp;quot;Times New Roman&amp;quot;, Times, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif, sans-serif; font-size: 16px;&quot;&gt;Streptomyces&lt;/em&gt;&lt;span style=&quot;color: rgb(31, 31, 31); font-family: ElsevierGulliver, Georgia, &amp;quot;Times New Roman&amp;quot;, Times, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif, sans-serif; font-size: 16px;&quot;&gt;&amp;nbsp;sp. UP1A-1 isolated from healthy solanaceae rhizosphere soil, exhibited the lowest disease incidence and increased fruit yield of solanaceae vegetables. However, the genomic and functional properties of UP1A-1 are unclear. Therefore, we conducted the present study to elucidate the genomic characteristics of UP1A-1 by whole genome sequencing. The results indicate that the genome of&amp;nbsp;&lt;/span&gt;&lt;em style=&quot;box-sizing: border-box; margin: 0px; padding: 0px; color: rgb(31, 31, 31); font-family: ElsevierGulliver, Georgia, &amp;quot;Times New Roman&amp;quot;, Times, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif, sans-serif; font-size: 16px;&quot;&gt;Streptomyces&lt;/em&gt;&lt;span style=&quot;color: rgb(31, 31, 31); font-family: ElsevierGulliver, Georgia, &amp;quot;Times New Roman&amp;quot;, Times, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif, sans-serif; font-size: 16px;&quot;&gt;&amp;nbsp;sp. UP1A-1 consists of 8,252,902&amp;nbsp;bp and contains 72.42&amp;nbsp;%&amp;nbsp;G&amp;nbsp;+&amp;nbsp;C. We identified the genes that confer plant growth promoting (PGP) function, which include those involved in siderophore production, indole-3-acetic acid biosynthesis, phosphate solubilization, nitrogen metabolism, and potassium metabolism. We also identified several other genes, such as chitinase, peroxidase, superoxide dismutase, catalase, proline biosynthesis, and glucose dehydrogenase, which are believed to be involved in the control of wilt disease. These genes revealed that the strain UP1A-1 has physiologically adapted to varied environmental conditions and could potentially control both abiotic and biotic stresses.&lt;/span&gt;&lt;/p&gt;
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	Foreign&lt;/p&gt;
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	1&lt;/p&gt;
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