<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jain, Prashant</style></author><author><style face="normal" font="default" size="100%">Shanthamurthy, Chethan D.</style></author><author><style face="normal" font="default" size="100%">Leviatan Ben-Arye, Shani</style></author><author><style face="normal" font="default" size="100%">Yehuda, Sharon</style></author><author><style face="normal" font="default" size="100%">Nandikol, Sharvani S.</style></author><author><style face="normal" font="default" size="100%">Thulasiram, V, Hirekodathakallu</style></author><author><style face="normal" font="default" size="100%">Padler-Karavani, Vered</style></author><author><style face="normal" font="default" size="100%">Kikkeri, Raghavendra</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Synthetic heparan sulfate ligands for vascular endothelial growth factor to modulate angiogenesis</style></title><secondary-title><style face="normal" font="default" size="100%">Chemical Communications</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">APR </style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">57</style></volume><pages><style face="normal" font="default" size="100%">3516-3519</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;We report the discovery of a potential heparan sulfate (HS) ligand to target several growth factors using 13 unique HS tetrasaccharide ligands. By employing an HS microarray and SPR, we deciphered the crucial structure-binding relationship of these glycans with the growth factors BMP2, VEGF(165), HB-EGF, and FGF2. Notably, GlcNHAc(6-O-SO3-)-IdoA(2-O-SO3-) (HT-2,6S-NAc) tetrasaccharide showed strong binding with the VEGF(165) growth factor. In vitro vascular endothelial cell proliferation, migration and angiogenesis was inhibited in the presence of VEGF(165) and HT-2,6S-NAc or HT-6S-NAc, revealing the potential therapeutic role of these synthetic HS ligands.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">28</style></issue><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">&lt;p&gt;Foreign&lt;/p&gt;</style></custom3><custom4><style face="normal" font="default" size="100%">&lt;p&gt;5.996&lt;/p&gt;</style></custom4></record></records></xml>