<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mane, Pramod C.</style></author><author><style face="normal" font="default" size="100%">Shinde, Manish D.</style></author><author><style face="normal" font="default" size="100%">Varma, Sanjana</style></author><author><style face="normal" font="default" size="100%">Chaudhari, Bhushan P.</style></author><author><style face="normal" font="default" size="100%">Fatehmulla, Amanullah</style></author><author><style face="normal" font="default" size="100%">Shahabuddin, M.</style></author><author><style face="normal" font="default" size="100%">Amalnerkar, Dinesh P.</style></author><author><style face="normal" font="default" size="100%">Aldhafiri, Abdullah M.</style></author><author><style face="normal" font="default" size="100%">Chaudhari, Ravindra D.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Highly sensitive label-free bio-interfacial colorimetric sensor based on silk fibroin-gold nanocomposite for facile detection of chlorpyrifos pesticide</style></title><secondary-title><style face="normal" font="default" size="100%">Scientific Reports</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">MAR</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">4198</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Herein, the preparation of gold nanoparticles-silk fibroin (SF-AuNPs) dispersion and its label-free colorimetric detection of the organophosphate pesticide, namely chlorpyrifos, at ppb level are reported. The silk fibroin solution was extracted from B. mori silk after performing degumming, dissolving and dialysis steps. This fibroin solution was used for synthesis of gold nanoparticles in-situ without using any external reducing and capping agent. X-ray Diffractometry (XRD), Field Emission Transmission Electron Microscopy (FETEM) along with Surface Plasmon Resonance based optical evaluation confirmed generation of gold nanoparticles within SF matrix. The resultant SF-AuNPs dispersion exhibited rapid and excellent colorimetric pesticide sensing response even at 10 ppb concentration. Effect of additional parameters viz. pH, ionic concentration and interference from other pesticide samples was also studied. Notably, SF-AuNPs dispersion exhibited selective colorimetric pesticide sensing response which can be calibrated. Furthermore, this method was extended to various simulated real life samples such as tap water, soil and agricultural products including plant residues to successfully detect the presence of chlorpyrifos pesticide. The proposed colorimetric sensor system is facile yet effective and can be employed by novice rural population and expert researchers alike. It can be exploited as preliminary tool for label-free colorimetric chlorpyrifos pesticide sensing in water and agricultural products.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">&lt;p&gt;Foreign&lt;/p&gt;
</style></custom3><custom4><style face="normal" font="default" size="100%">&lt;p&gt;3.998&lt;/p&gt;
</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jaiswal, Neha</style></author><author><style face="normal" font="default" size="100%">Chaudhari, Ravindra D.</style></author><author><style face="normal" font="default" size="100%">Chaudhari, Bhushan P.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Understanding fundamentals of hepatocellular carcinoma to design next-generation chitosan nano-formulations: Beyond chemotherapy stride</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Drug Delivery Science and Technology</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">chitosan nanoparticles</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatocellular carcinoma</style></keyword><keyword><style  face="normal" font="default" size="100%">Pathophysiology</style></keyword><keyword><style  face="normal" font="default" size="100%">Surface biomarkers</style></keyword><keyword><style  face="normal" font="default" size="100%">Targeted Drug Delivery</style></keyword><keyword><style  face="normal" font="default" size="100%">Tumor microenvironment</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">AUG</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">58</style></volume><pages><style face="normal" font="default" size="100%">101723</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Hepatocellular carcinoma (HCC) is the deadliest form of liver cancer. Clinically, the main strategies currently being used for the treatment of HCC are surgery, radiotherapy and chemotherapy. Conventional chemotherapy has major drawbacks such as poor bioavailability, high-dose requirements, adverse side effects, low therapeutic indices, and non-specific drug targeting. Therefore, targeted drug delivery systems are fast becoming new tools for the selective killing of cancer cells. Chitosan (CS) is a biodegradable, biocompatible, cationic and natural biopolymer that also exhibits anti-cancer property which is now being explored as a promising candidate for targeted drug delivery. This review outlines an overview of the causative agents, microenvironment, pathophysiology, surface-biomarkers and physiological barriers of HCC. Then, the cellular internalization pathways of nanomedicine and the important physicochemical properties of delivery agents are discussed. The benefits of targeted therapy over conventional therapy with regard to HCC are also discussed. The main objective of this review was to summarize the current knowledge in the field of chitosan-based drug delivery for the management of HCC along with its limitations in a comprehensive and systematic way. This review attempts to provide a holistic roadmap for designing the next-generation chitosan-based drug delivery systems for HCC management.&lt;/p&gt;
</style></abstract><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">&lt;p&gt;Foreign&lt;/p&gt;
</style></custom3><custom4><style face="normal" font="default" size="100%">&lt;p&gt;2.734&lt;/p&gt;
</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mane, Pramod C.</style></author><author><style face="normal" font="default" size="100%">Kadam, Deepali D.</style></author><author><style face="normal" font="default" size="100%">Khadse, Ashok N.</style></author><author><style face="normal" font="default" size="100%">Chaudhari, Aditya R.</style></author><author><style face="normal" font="default" size="100%">Ughade, Supriya P.</style></author><author><style face="normal" font="default" size="100%">Agawane, Sachin B.</style></author><author><style face="normal" font="default" size="100%">Chaudhari, Ravindra D.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Green adeptness in synthesis of non-toxic copper and cobalt oxide nanocomposites with multifaceted bioactivities</style></title><secondary-title><style face="normal" font="default" size="100%">Cancer Nanotechnology</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Achatina fulica mucus</style></keyword><keyword><style  face="normal" font="default" size="100%">Bio-nanocomposites</style></keyword><keyword><style  face="normal" font="default" size="100%">Biological activities</style></keyword><keyword><style  face="normal" font="default" size="100%">Characterization</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">DEC</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">79</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;
	Background: In the present era, we are facing different health problems mainly concerning with drug resistance in microorganisms as well as in cancer cells. In addition, we are also facing the problems of controlling oxidative stress and insect originated diseases like dengue, malaria, chikungunya, etc. originated from mosquitoes. In this investigation, we unfurled the potential of Achatina fulica mucus in green synthesis of mucus mediated copper oxide bio-nanocomposites (SM-CuONC) and cobalt oxide bio-nanocomposites (SM-Co3O4NC). Herein we carried out the physico-chemical characterization like UV-Vis spectra, X-ray diffraction (XRD), Field Emission Scanning Electron Microscopy (FESEM), Transmission electron microscopy (TEM), Energy Dispersive X-ray Analysis (EDAX) and X-ray photoelectron spectroscopy (XPS) of as synthesized bio-nanocomposites. Both the bio-nanocomposites were tested for their potential as antimicrobial activity using well diffusion assay, anticancer activity by MTT assay, antioxidant activity by phosphomolybdenum assay and mosquito larvicidal activity.Results: The results of this study revealed that, SM-CuONC and SM-Co3O4NC were synthesized successfully using A. fulica mucus. The FESEM and TEM data reveal the formation of nanoparticles with quasi-spherical morphology and average particle size of similar to 18 nm for both nanocomposites. The EDAX peak confirms the presence of elemental copper and cobalt in the analyzed samples. The X-ray diffraction analysis confirmed the crystalline nature of the CuO and Co3O4. The result of anti microbial study exhibited that, SM-CuONC showed maximum antimicrobial activity against Escherichia coli NCIM 2065 and Aspergillus fumigatus NCIM 902 which were noted as 2.36 +/- 0.31 and 2.36 +/- 0.59 cm resp. at 60 mu g/well concentration. The result of anticancer activity for SM-CuONC was exhibited as, 68.66 +/- 3.72, 62.66 +/- 3.61 and 71.00 +/- 2.36 percent kill, while SM-Co3O4NC exhibited 61.00 +/- 3.57, 72.66 +/- 4.50 and 71.66 +/- 4.22 percent kill against Human colon cancer (HCT-15), Cervical cancer (HeLa), and Breast cancer (MDA-MB-231) cell lines, respectively, at 20 mu g/well concentration. Both the nanocomposites also exhibited better antioxidant activity. Total antioxidant activity for SM-CuONC at 50 mu g/ml concentration was found to be highest as 55.33 +/- 3.72 while that of SM-Co(3)O(4)Ns was 52.00 +/- 3.22 mM of ascorbic acid/mu g respectively. Both bio-nanocomposites also exhibited 100% mosquito larvicidal activity at concentration ranging from 40 to 50 mg/l. During cytotoxicity study it is noted that at 5 mu g/well concentration, SM-CuO and SM-Co3O4NCs suspension showed more than 97% viability of normal (L929) cell lines. We also studied phytotoxicity of both bio-nanocomposites on Triticum aestivum. In this study, 100% seed germination was observed when seeds are treated with SM-CuONC and SM-Co3O4NC at 500 mg/l and 250 mg/l concentration respectively.Conclusions: This study concludes that in future as synthesized SM-CuONC and SM-Co3O4NC can be used in pharmaceutical, health care system for betterment and welfare of human life as both bio-nanocomposites exhibits better antimicrobial, anticancer, antioxidant and mosquito larvicidal potential.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">&lt;p&gt;
	Foreign&lt;/p&gt;
</style></custom3><custom4><style face="normal" font="default" size="100%">&lt;p&gt;
	5.7&lt;/p&gt;
</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Pramod C.</style></author><author><style face="normal" font="default" size="100%">Pawar, Jayant</style></author><author><style face="normal" font="default" size="100%">Mane, Deepali P.</style></author><author><style face="normal" font="default" size="100%">Khadase, Ashok N.</style></author><author><style face="normal" font="default" size="100%">Chaudhari, Aditya R.</style></author><author><style face="normal" font="default" size="100%">Ughade, Supriya P.</style></author><author><style face="normal" font="default" size="100%">Chaudhari, Ravindra D.</style></author><author><style face="normal" font="default" size="100%">Agawane, Sachin B.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Green synthesis of silver and gold ultra nanocomposites from silk fibroin and their application for treatment of endodontic infections</style></title><secondary-title><style face="normal" font="default" size="100%">Emergent Materials</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">JUN</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">2645–2660</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;
	&lt;span style=&quot;font-family: Merriweather, serif; font-size: 18px;&quot;&gt;The present study is designed to investigate the antibacterial efficacy of&amp;nbsp;&lt;/span&gt;&lt;i style=&quot;box-sizing: inherit; font-family: Merriweather, serif; font-size: 18px;&quot;&gt;B. mori&lt;/i&gt;&lt;span style=&quot;font-family: Merriweather, serif; font-size: 18px;&quot;&gt;&amp;nbsp;silk fibroin based silver and gold ultra bio-nanocomposites (SF-AgUNC and SF-AuUNC) against&amp;nbsp;&lt;/span&gt;&lt;i style=&quot;box-sizing: inherit; font-family: Merriweather, serif; font-size: 18px;&quot;&gt;Enterococcus faecalis&lt;/i&gt;&lt;span style=&quot;font-family: Merriweather, serif; font-size: 18px;&quot;&gt;&amp;nbsp;for endodontic disinfection. The SF-AgUNC and SF-AuUNC based irrigant solution was tested&amp;nbsp;&lt;/span&gt;&lt;i style=&quot;box-sizing: inherit; font-family: Merriweather, serif; font-size: 18px;&quot;&gt;in- vitro&lt;/i&gt;&lt;span style=&quot;font-family: Merriweather, serif; font-size: 18px;&quot;&gt;&amp;nbsp;against&amp;nbsp;&lt;/span&gt;&lt;i style=&quot;box-sizing: inherit; font-family: Merriweather, serif; font-size: 18px;&quot;&gt;Enterococcus faecalis&lt;/i&gt;&lt;span style=&quot;font-family: Merriweather, serif; font-size: 18px;&quot;&gt;&amp;nbsp;(ATCC: 29212). In this direction, SF-AgUNC and SF-AuUNC synthesized by silk fibroin are very important as they are economically cheap and easy to biosynthesize. The synthesis of SF-AgUNC and SF-AuUNC was accomplished by dissolving 1 mM silver nitrate and 0.5 mM auric chloride respectively in 10 ml of fibroin as precursors. The structural and morphological analysis was executed by UV-Vis Spectroscopy, X-ray diffraction (XRD), Fourier transform infrared spectroscopic analysis (FTIR), Field Emission Scanning Electron Microscopy (FESEM), Transmission electron microscopy (TEM), Energy-dispersive X-ray spectroscopy (EDAX) and X-ray photoelectron spectroscopy (XPS). The qualitative antimicrobial activity of SF-AgUNC and SF-AuUNC were performed against inoculum of&amp;nbsp;&lt;/span&gt;&lt;i style=&quot;box-sizing: inherit; font-family: Merriweather, serif; font-size: 18px;&quot;&gt;Enterococcus faecalis&lt;/i&gt;&lt;span style=&quot;font-family: Merriweather, serif; font-size: 18px;&quot;&gt;&amp;nbsp;containing 1⨯10&lt;/span&gt;&lt;sup style=&quot;box-sizing: inherit; font-family: Merriweather, serif;&quot;&gt;5&lt;/sup&gt;&lt;span style=&quot;font-family: Merriweather, serif; font-size: 18px;&quot;&gt;&amp;nbsp;CFU/ ml. The same solutions were tested on dentine specimens inoculated with bacterial cultures and found remarkable biofilm reduction. The structural and morphological analysis reveals the formation of SF-AgUNC and SF-AuUNC having quasi-spherical morphology. The average particle size for SF-AgUNC and SF-AuUNC was same (~ 8 nm). The XRD study confirms that, both SF-AgUNC and SF-AuUNC were crystalline in nature. The bacterial growth inhibition and significant biofilm reduction was observed on dentine specimens treated with SF-AgUNC, SF-AuUNC and positive control. In antibacterial study, at 30 μg/well concentration of SF-AgUNC and SF-AuUNC, 3.13 ± 0.22 and 1.13 ± 0.22 cm of zone of inhibition was noted respectively. Moreover, growth of&amp;nbsp;&lt;/span&gt;&lt;i style=&quot;box-sizing: inherit; font-family: Merriweather, serif; font-size: 18px;&quot;&gt;Enterococcus faecalis&lt;/i&gt;&lt;span style=&quot;font-family: Merriweather, serif; font-size: 18px;&quot;&gt;&amp;nbsp;was completely inhibited at 20 μg/ml and 30 μg/ml when treated with SF-AgUNC and SF-AuUNC respectively. Hence, the present study concludes that SF-AgUNC and SF-AuUNC can be used as an effective intracanal medicament for the treatment of dental problems with no cyto toxicity.&lt;/span&gt;&lt;/p&gt;
</style></abstract><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">&lt;p&gt;Foreign&lt;/p&gt;
</style></custom3><custom4><style face="normal" font="default" size="100%">&lt;p&gt;
	4.8&lt;/p&gt;
</style></custom4></record></records></xml>