<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Allaka, Bhargava Sai</style></author><author><style face="normal" font="default" size="100%">Kanchrana, Madhu</style></author><author><style face="normal" font="default" size="100%">Gamidi, Rama Krishna</style></author><author><style face="normal" font="default" size="100%">Basavoju, Srinivas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">     Synthesis of quinazolinone based spirocyclopropanes via [3?+?2] cycloaddition reaction: in silico anti-tubercular molecular docking studies and ADME prediction</style></title><secondary-title><style face="normal" font="default" size="100%">Polycyclic Aromatic Compounds</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">SEP</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">44</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;
	&lt;span style=&quot;color: rgb(51, 51, 51); font-family: &amp;quot;Open Sans&amp;quot;, sans-serif; font-size: 17.6px;&quot;&gt;A highly efficient cascade annulation approach is developed for the synthesis of novel quinazolinone-based spirocyclopropanes&amp;nbsp;&lt;/span&gt;&lt;i style=&quot;box-sizing: border-box; color: rgb(51, 51, 51); font-family: &amp;quot;Open Sans&amp;quot;, sans-serif; font-size: 17.6px;&quot;&gt;via&lt;/i&gt;&lt;span style=&quot;color: rgb(51, 51, 51); font-family: &amp;quot;Open Sans&amp;quot;, sans-serif; font-size: 17.6px;&quot;&gt;&amp;nbsp;three-component [3 + 2] cycloaddition reaction with aldehydes, tosylhydrazide and quinazolinyl chalcones. The reaction features the formation of two C–C bonds and three stereogenic centers. A variety of highly functionalized spirocyclopropyl quinazolinones were obtained in good yields under mild reaction conditions. Furthermore,&amp;nbsp;&lt;/span&gt;&lt;i style=&quot;box-sizing: border-box; color: rgb(51, 51, 51); font-family: &amp;quot;Open Sans&amp;quot;, sans-serif; font-size: 17.6px;&quot;&gt;in silico&lt;/i&gt;&lt;span style=&quot;color: rgb(51, 51, 51); font-family: &amp;quot;Open Sans&amp;quot;, sans-serif; font-size: 17.6px;&quot;&gt;&amp;nbsp;anti-tubercular (anti-TB) molecular docking studies were performed for the generated compounds against three Mycobacterium tuberculosis proteins with PDBID: 1DF7, 1P44 and 4TZK. ADME prediction were evaluated for the drug like properties of the synthesized compounds.&lt;/span&gt;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">7</style></issue><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">&lt;p&gt;
	Foreign&lt;/p&gt;
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	2.5&lt;/p&gt;
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