<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">SreeHarsha, Nagaraja</style></author><author><style face="normal" font="default" size="100%">Ghorpade, Ravindra, V.</style></author><author><style face="normal" font="default" size="100%">Alzahrani, Abdullah Mossa</style></author><author><style face="normal" font="default" size="100%">Al-Dhubiab, Bandar E.</style></author><author><style face="normal" font="default" size="100%">Venugopala, Katharigatta N.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Immobilization studies of Candida Antarctica lipase B on gallic acid resin-grafted magnetic iron oxide nanoparticles</style></title><secondary-title><style face="normal" font="default" size="100%">International Journal of nanomedicine</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">MAY</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">3235-3244</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Purpose: Here, we present &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; successful preparation &lt;span class=&quot;hitHilite&quot;&gt;of&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;a&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;highly&lt;/span&gt; efficient &lt;span class=&quot;hitHilite&quot;&gt;gallic&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;acid&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;resin grafted&lt;/span&gt; with &lt;span class=&quot;hitHilite&quot;&gt;magnetic&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;nanoparticles&lt;/span&gt; (MNPs) and containing &lt;span class=&quot;hitHilite&quot;&gt;a&lt;/span&gt; branched brush polymeric shell.&lt;br /&gt;
	&lt;br /&gt;
	Methods: &lt;span class=&quot;hitHilite&quot;&gt;Using&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;a&lt;/span&gt; convenient co-precipitation &lt;span class=&quot;hitHilite&quot;&gt;method&lt;/span&gt;, we prepared Fe3O4 &lt;span class=&quot;hitHilite&quot;&gt;nanoparticles&lt;/span&gt; stabilized by citric &lt;span class=&quot;hitHilite&quot;&gt;acid&lt;/span&gt;. These &lt;span class=&quot;hitHilite&quot;&gt;nanoparticles&lt;/span&gt; underwent further silica modification and amino functionalization followed by &lt;span class=&quot;hitHilite&quot;&gt;gallic&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;acid&lt;/span&gt; functionalization &lt;span class=&quot;hitHilite&quot;&gt;on&lt;/span&gt; their surface. Under alkaline conditions, we used &lt;span class=&quot;hitHilite&quot;&gt;a&lt;/span&gt; condensation &lt;span class=&quot;hitHilite&quot;&gt;reaction&lt;/span&gt; that combined formaldehyde and &lt;span class=&quot;hitHilite&quot;&gt;gallic&lt;/span&gt;, &lt;span class=&quot;hitHilite&quot;&gt;to&lt;/span&gt; graft &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;gallic&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;acid&lt;/span&gt;-formaldehyde resin &lt;span class=&quot;hitHilite&quot;&gt;on&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; surface. We then evaluated &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; polymer-grafted MNPs &lt;span class=&quot;hitHilite&quot;&gt;to&lt;/span&gt; assay &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;Candida&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;Antarctica&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;B&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;lipase&lt;/span&gt;(Cal-&lt;span class=&quot;hitHilite&quot;&gt;B&lt;/span&gt;) &lt;span class=&quot;hitHilite&quot;&gt;immobilization&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;via&lt;/span&gt; physical adsorption.&lt;br /&gt;
	&lt;br /&gt;
	Conclusion: Furthermore, during optimization &lt;span class=&quot;hitHilite&quot;&gt;of&lt;/span&gt; parameters that defined conditions &lt;span class=&quot;hitHilite&quot;&gt;of&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;immobilization&lt;/span&gt;, we found that &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; optimum &lt;span class=&quot;hitHilite&quot;&gt;immobilization&lt;/span&gt; was achieved in 15 mins Also, optimal &lt;span class=&quot;hitHilite&quot;&gt;immobilization&lt;/span&gt; temperature and pH were 38 degrees C and 7.5, respectively. In addition, &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; reusability study &lt;span class=&quot;hitHilite&quot;&gt;of&lt;/span&gt; immobilized &lt;span class=&quot;hitHilite&quot;&gt;lipase&lt;/span&gt; polymer-grafted MNPs was done by isolating &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; MNPs from &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;reaction&lt;/span&gt; medium &lt;span class=&quot;hitHilite&quot;&gt;using&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;magnetic&lt;/span&gt; separation, which showed that grafted MNPs reached 5 cycles with 91% activity retention.&lt;/p&gt;
</style></abstract><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">&lt;p&gt;Foreign&lt;/p&gt;
</style></custom3><custom4><style face="normal" font="default" size="100%">&lt;p&gt;4.471&lt;/p&gt;
</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bairagi, Keshab M.</style></author><author><style face="normal" font="default" size="100%">Younis, Nancy S.</style></author><author><style face="normal" font="default" size="100%">Emeka, Promise M.</style></author><author><style face="normal" font="default" size="100%">Sangtani, Ekta</style></author><author><style face="normal" font="default" size="100%">Gonnade, Rajesh G.</style></author><author><style face="normal" font="default" size="100%">Venugopala, Katharigatta N.</style></author><author><style face="normal" font="default" size="100%">Alwassil, I. Osama</style></author><author><style face="normal" font="default" size="100%">Khalil, Hany E.</style></author><author><style face="normal" font="default" size="100%">Nayak, Susanta K.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antidiabetic activity of dihydropyrimidine scaffolds and structural insight by single crystal x-ray studies</style></title><secondary-title><style face="normal" font="default" size="100%">Medicinal Chemistry</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">anti-Diabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">blood glucose levels</style></keyword><keyword><style  face="normal" font="default" size="100%">dihydropyrimidine</style></keyword><keyword><style  face="normal" font="default" size="100%">hypoglycemic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Streptozotocin</style></keyword><keyword><style  face="normal" font="default" size="100%">type 2 diabetes mellitus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">JAN</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">996-1003</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Background: This research project is designed to identify the anti-diabetic effects of the newly synthesized compounds to conclude the perspective of consuming one or more of these new synthetic compounds for diabetes management. Introduction: A series of dihydropyrimidine (DHPM) derivative bearing electron releasing and electron-withdrawing substituent's on phenyl ring (a-j) were synthesized and screened for antihyperglycemic(anti-diabetic) activity on streptozotocin (STZ) induced diabetic rat model. The newly synthesized compounds were characterized by using FT-IR, melting point, H-1 and C-13 NMR analysis. The crystal structure and supramolecular features were analyzed through single-crystal X-ray study. Anti-diabetic activity testing of newly prepared DHPM scaffolds was mainly based on their relative substituent on the phenyl ring along with urea and thiourea. Among the synthesized DHPM scaffold, the test compound c having chlorine group on phenyl ring at the ortho position to the hydropyrimidine ring with urea and methyl acetoacetate derivative shows moderate lowering of glucose level. However, the title compounds methyl 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimi dine-5-carboxylate(g) and ethyl 4-(3-ethoxy-4-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydroprimidine- 5-carboxylate(h) having methoxy and ethoxy substituents on phenyl ring show significant hypoglycemic activity compared to the remaining compounds from the Scheme 1. Methods: The experimental rat models for the study were divided into 13 groups (n = 10); group 1 animals were treated with 0.5% CMC (0.5mL) (vehicle); group 2 were considered the streptozotocin (STZ)/nicotinamide diabetic control group (DC) and untreated, group 3 diabetic animals were administered with gliclazide 50 mg/kg and act as a reference drug group. The remaining groups of the diabetic animals were administered with the newly synthesized dihydropyrimidine compounds in a single dose of 50 mg/kg orally using the oral gavage, daily for 7 days continuously. The blood glucose level was measured before and 72 hrs after nicotinamide-STZ injection, for confirmation of hyperglycemia and type 2 diabetes development. Results: Blood glucose levels were significantly (p&amp;lt;0.05) reduced after treatment with these derivatives. The mean percentage reduction for gliclazide was 50%, while that of synthesized compounds were approximately 36%. Conclusion: Our result suggests that the synthesized new DEEM derivative containing alkoxy group on the phenyl ring shows a significant lowering of glucose level compared to other derivatives.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">7</style></issue><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">&lt;p&gt;Foreign&lt;/p&gt;
</style></custom3><custom4><style face="normal" font="default" size="100%">&lt;p&gt;2.577&lt;/p&gt;
</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ingle, Kapil S.</style></author><author><style face="normal" font="default" size="100%">Mohurle, Smital A.</style></author><author><style face="normal" font="default" size="100%">Bairagi, Keshab M.</style></author><author><style face="normal" font="default" size="100%">Shaikh, Tabrez R.</style></author><author><style face="normal" font="default" size="100%">Venugopala, Katharigatta N.</style></author><author><style face="normal" font="default" size="100%">Chandrashekharappa, Sandeep</style></author><author><style face="normal" font="default" size="100%">Gonnade, Rajesh G.</style></author><author><style face="normal" font="default" size="100%">Nayak, Susanta K.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Synthesis, crystal structure and Hirshfeld surface analysis of the hydrated form of N’, N-(1,4-phenylenebis(methanylylidene) di(iso-nicotinic hydrazide)</style></title><secondary-title><style face="normal" font="default" size="100%">Chemical Data Collections</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">AUG</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">28</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;span style=&quot;color: rgb(46, 46, 46); font-family: NexusSerif, Georgia, &amp;quot;Times New Roman&amp;quot;, Times, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif; font-size: 18px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400;&quot;&gt;The title compound, C&lt;/span&gt;&lt;span style=&quot;font-size: 13.5px; line-height: 0; position: relative; bottom: -0.25em; color: rgb(46, 46, 46); font-family: NexusSerif, Georgia, &amp;quot;Times New Roman&amp;quot;, Times, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400;&quot;&gt;20&lt;/span&gt;&lt;span style=&quot;color: rgb(46, 46, 46); font-family: NexusSerif, Georgia, &amp;quot;Times New Roman&amp;quot;, Times, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif; font-size: 18px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400;&quot;&gt;H&lt;/span&gt;&lt;span style=&quot;font-size: 13.5px; line-height: 0; position: relative; bottom: -0.25em; color: rgb(46, 46, 46); font-family: NexusSerif, Georgia, &amp;quot;Times New Roman&amp;quot;, Times, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400;&quot;&gt;16&lt;/span&gt;&lt;span style=&quot;color: rgb(46, 46, 46); font-family: NexusSerif, Georgia, &amp;quot;Times New Roman&amp;quot;, Times, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif; font-size: 18px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400;&quot;&gt;N&lt;/span&gt;&lt;span style=&quot;font-size: 13.5px; line-height: 0; position: relative; bottom: -0.25em; color: rgb(46, 46, 46); font-family: NexusSerif, Georgia, &amp;quot;Times New Roman&amp;quot;, Times, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400;&quot;&gt;6&lt;/span&gt;&lt;span style=&quot;color: rgb(46, 46, 46); font-family: NexusSerif, Georgia, &amp;quot;Times New Roman&amp;quot;, Times, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif; font-size: 18px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400;&quot;&gt;O&lt;/span&gt;&lt;span style=&quot;font-size: 13.5px; line-height: 0; position: relative; bottom: -0.25em; color: rgb(46, 46, 46); font-family: NexusSerif, Georgia, &amp;quot;Times New Roman&amp;quot;, Times, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400;&quot;&gt;2&lt;/span&gt;&lt;span style=&quot;color: rgb(46, 46, 46); font-family: NexusSerif, Georgia, &amp;quot;Times New Roman&amp;quot;, Times, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif; font-size: 18px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400;&quot;&gt;&amp;nbsp;was synthesized by reflux with isonicotinic hydrazide and terephthaldehyde in ethanol solvent with the acidic condition. The single-crystal X-ray structure determination of the title compound,&amp;nbsp;&lt;/span&gt;&lt;em style=&quot;color: rgb(46, 46, 46); font-family: NexusSerif, Georgia, &amp;quot;Times New Roman&amp;quot;, Times, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif; font-size: 18px; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400;&quot;&gt;N, N&lt;/em&gt;&lt;span style=&quot;color: rgb(46, 46, 46); font-family: NexusSerif, Georgia, &amp;quot;Times New Roman&amp;quot;, Times, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif; font-size: 18px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400;&quot;&gt;-(1,4-phenylene bis (methanylylidene) di(iso-nicotinic hydrazide), reveals that the molecule crystallizes in center of symmetry with water molecules (Dihydrated form, C&lt;/span&gt;&lt;span style=&quot;font-size: 13.5px; line-height: 0; position: relative; bottom: -0.25em; color: rgb(46, 46, 46); font-family: NexusSerif, Georgia, &amp;quot;Times New Roman&amp;quot;, Times, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400;&quot;&gt;20&lt;/span&gt;&lt;span style=&quot;color: rgb(46, 46, 46); font-family: NexusSerif, Georgia, &amp;quot;Times New Roman&amp;quot;, Times, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif; font-size: 18px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400;&quot;&gt;H&lt;/span&gt;&lt;span style=&quot;font-size: 13.5px; line-height: 0; position: relative; bottom: -0.25em; color: rgb(46, 46, 46); font-family: NexusSerif, Georgia, &amp;quot;Times New Roman&amp;quot;, Times, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400;&quot;&gt;16&lt;/span&gt;&lt;span style=&quot;color: rgb(46, 46, 46); font-family: NexusSerif, Georgia, &amp;quot;Times New Roman&amp;quot;, Times, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif; font-size: 18px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400;&quot;&gt;N&lt;/span&gt;&lt;span style=&quot;font-size: 13.5px; line-height: 0; position: relative; bottom: -0.25em; color: rgb(46, 46, 46); font-family: NexusSerif, Georgia, &amp;quot;Times New Roman&amp;quot;, Times, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400;&quot;&gt;6&lt;/span&gt;&lt;span style=&quot;color: rgb(46, 46, 46); font-family: NexusSerif, Georgia, &amp;quot;Times New Roman&amp;quot;, Times, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif; font-size: 18px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400;&quot;&gt;O&lt;/span&gt;&lt;span style=&quot;font-size: 13.5px; line-height: 0; position: relative; bottom: -0.25em; color: rgb(46, 46, 46); font-family: NexusSerif, Georgia, &amp;quot;Times New Roman&amp;quot;, Times, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400;&quot;&gt;2&lt;/span&gt;&lt;span style=&quot;color: rgb(46, 46, 46); font-family: NexusSerif, Georgia, &amp;quot;Times New Roman&amp;quot;, Times, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif; font-size: 18px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400;&quot;&gt;.2H&lt;/span&gt;&lt;span style=&quot;font-size: 13.5px; line-height: 0; position: relative; bottom: -0.25em; color: rgb(46, 46, 46); font-family: NexusSerif, Georgia, &amp;quot;Times New Roman&amp;quot;, Times, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400;&quot;&gt;2&lt;/span&gt;&lt;span style=&quot;color: rgb(46, 46, 46); font-family: NexusSerif, Georgia, &amp;quot;Times New Roman&amp;quot;, Times, STIXGeneral, &amp;quot;Cambria Math&amp;quot;, &amp;quot;Lucida Sans Unicode&amp;quot;, &amp;quot;Microsoft Sans Serif&amp;quot;, &amp;quot;Segoe UI Symbol&amp;quot;, &amp;quot;Arial Unicode MS&amp;quot;, serif; font-size: 18px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight: 400;&quot;&gt;O) through N-H∙∙∙O and C-H∙∙∙O hydrogen bondings. Further, the crystal structure is stabilized by O-H∙∙∙O and weak C-H∙∙∙N hydrogen bondings with the formation of infinite chain and dimer. Further, surface analysis and fingerprint plot reveal that the significant hydrogen bonding such as H•••O (15.9%) and N•••H (11.4%) interactions play the most crucial role for its molecular packing.&lt;/span&gt;&lt;/p&gt;</style></abstract><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">&lt;p&gt;Foreign&lt;/p&gt;</style></custom3><custom4><style face="normal" font="default" size="100%">&lt;p&gt;2.22&lt;/p&gt;</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bairagi, Keshab M.</style></author><author><style face="normal" font="default" size="100%">Younis, Nancy Safwat</style></author><author><style face="normal" font="default" size="100%">Emeka, Promise Madu</style></author><author><style face="normal" font="default" size="100%">Venugopala, Katharigatta N.</style></author><author><style face="normal" font="default" size="100%">Alwassil, I, Osama</style></author><author><style face="normal" font="default" size="100%">Khalil, Hany Ezzat</style></author><author><style face="normal" font="default" size="100%">Sangtani, Ekta</style></author><author><style face="normal" font="default" size="100%">Gonnade, Rajesh G.</style></author><author><style face="normal" font="default" size="100%">Mohanlall, Viresh</style></author><author><style face="normal" font="default" size="100%">Nayak, Susanta K.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemistry, anti-diabetic activity and structural analysis of substituted dihydropyrimidine analogues</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Molecular Structure</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Dihydropyrimidine (DHPM)</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypoglycemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Streptozotocin (STZ)</style></keyword><keyword><style  face="normal" font="default" size="100%">Type-2 diabetes mellitus (T2DM)</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">MAR </style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">1227</style></volume><pages><style face="normal" font="default" size="100%">129412</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;In an effort to identify an anti-diabetic agent, a series of methyl/ethyl 4-(hydroxyphenyl)-6-methyl-2-oxo/thioxo-1,2,3,4 tetrahydropyrimidine-5-carboxylate analogues (4a-h) have been synthesized, purified, and characterized by using Fourier-Transform Infrared Spectroscopy (FT-IR) and NMR (H-1 and C-13). The synthesized compounds were screened for anti-hyperglycemic activity using Streptozotocin (STZ) induced diabetic rat model. The anti-hyperglycemic activity of dihydropyrimidine (DHPM) compound is mainly analyzed with the variation of substituents present on the phenyl ring and urea/thiourea group on pharmacophoric features. Further, the crystal structure and supramolecular characteristics of two compounds 4c and 4f were analyzed through a single-crystal X-ray method and the Hirshfeld Surface Analysis, which shows hydrogen bonding through N-H center dot center dot center dot O and N-H center dot center dot center dot S interactions with the formation of ring motif in the crystal structure. It is interesting to note that among the title compounds, the 4a, 4e, 4f, and 4g significantly displayed a better hypoglycemic effect in vivo rat model study. (C) 2020 Elsevier B.V. All rights reserved.&lt;/p&gt;
</style></abstract><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">&lt;p&gt;Foreign&lt;/p&gt;
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