<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sharma, Mrityunjay</style></author><author><style face="normal" font="default" size="100%">Acharya, Roopashree B.</style></author><author><style face="normal" font="default" size="100%">Kulkarni, Amol A</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%"> Exploring the steady operation of a continuous pilot plant for the di-nitration reaction </style></title><secondary-title><style face="normal" font="default" size="100%">Chemical Engineering &amp; Technology</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">AUG</style></date></pub-dates></dates><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;span class=&quot;hitHilite&quot;&gt;Continuous&lt;/span&gt;-flow synthesis &lt;span class=&quot;hitHilite&quot;&gt;of&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; selective herbicide pendimethalin was demonstrated in both &lt;span class=&quot;hitHilite&quot;&gt;a&lt;/span&gt; laboratory-scale and &lt;span class=&quot;hitHilite&quot;&gt;a&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;pilot&lt;/span&gt;-scale reactor using only concentrated nitric acid as nitrating agent. &lt;span class=&quot;hitHilite&quot;&gt;The&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;di-nitration&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;reaction&lt;/span&gt; follows second-order kinetics where &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;reaction&lt;/span&gt; is first order with respect to both reactant and nitric acid. &lt;span class=&quot;hitHilite&quot;&gt;The&lt;/span&gt; pinched-tube reactor was chosen &lt;span class=&quot;hitHilite&quot;&gt;for&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;pilot&lt;/span&gt;-scale reactor fabrication due to its excellent mixing and mass transfer characteristics compared to &lt;span class=&quot;hitHilite&quot;&gt;a&lt;/span&gt; straight-tube reactor. &lt;span class=&quot;hitHilite&quot;&gt;The&lt;/span&gt; estimated mass transfer coefficient showed similar nature in &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; laboratory-scale and &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;pilot&lt;/span&gt;-scale pinched-tube reactor, ensuring similar performance at &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;pilot&lt;/span&gt; scale. &lt;span class=&quot;hitHilite&quot;&gt;Di-nitration&lt;/span&gt; in &lt;span class=&quot;hitHilite&quot;&gt;continuous&lt;/span&gt; flow, inline quenching, extraction, and phase separation are some &lt;span class=&quot;hitHilite&quot;&gt;of&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; salient features &lt;span class=&quot;hitHilite&quot;&gt;of&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; developed &lt;span class=&quot;hitHilite&quot;&gt;pilot&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;plant&lt;/span&gt;. &lt;span class=&quot;hitHilite&quot;&gt;The&lt;/span&gt; importance &lt;span class=&quot;hitHilite&quot;&gt;of&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; start-up time &lt;span class=&quot;hitHilite&quot;&gt;for&lt;/span&gt; achieving &lt;span class=&quot;hitHilite&quot;&gt;steady&lt;/span&gt; state in &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; flow system at &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; large scale is highlighted.&lt;br /&gt;
	&amp;nbsp;&lt;/p&gt;
</style></abstract><work-type><style face="normal" font="default" size="100%">Article; Early Access</style></work-type><custom3><style face="normal" font="default" size="100%">&lt;p&gt;Foreign&lt;/p&gt;
</style></custom3><custom4><style face="normal" font="default" size="100%">&lt;p&gt;&lt;span class=&quot;info_value&quot;&gt;2.418&lt;/span&gt;&lt;/p&gt;
</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hussain, Arshad</style></author><author><style face="normal" font="default" size="100%">Sharma, Mrityunjay</style></author><author><style face="normal" font="default" size="100%">Patil, Suneha</style></author><author><style face="normal" font="default" size="100%">Acharya, Roopashree B.</style></author><author><style face="normal" font="default" size="100%">Kute, Mahesh</style></author><author><style face="normal" font="default" size="100%">Waghchaure, Aishwarya</style></author><author><style face="normal" font="default" size="100%">Kulkarni, Amol A.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Design and scale-up of continuous di-nitration reaction using pinched tube flow reactor</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Flow Chemistry</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">continuous flow</style></keyword><keyword><style  face="normal" font="default" size="100%">nitration</style></keyword><keyword><style  face="normal" font="default" size="100%">Pinched tube</style></keyword><keyword><style  face="normal" font="default" size="100%">RTD</style></keyword><keyword><style  face="normal" font="default" size="100%">scale-up</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">SEP</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">611-624</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Scale-up of the di-nitration reaction for synthesis of selective herbicide pendimethalin using only nitric acid in continuous flow is presented in this work. This work showcases an approach for smooth scale-up for an herbicide for a production capacity of 50 kg/day using a pinched tube reactor. The approach begins with the batch experiments followed by flow synthesis using a 1/8-inchSS316 helical coil tube where kinetics of the di-nitration was determined, and process optimization was done. Systematic approach was followed for quantification of heat transfer, mass transfer and residence time distribution and scale-up. Detailed scale-up methodology is presented with effect of relevant parameters for successful scale-up. Modular pilot plant with inline quenching, extraction and separation are some of the salient features presented in this work.</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">Foreign</style></custom3><custom4><style face="normal" font="default" size="100%">2.786</style></custom4></record></records></xml>