<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>47</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nikalje, Anna Pratima G.</style></author><author><style face="normal" font="default" size="100%">Nimbalkar, Ms Urja D.</style></author><author><style face="normal" font="default" size="100%">Tupe, Santosh</style></author><author><style face="normal" font="default" size="100%">Vazquez, Julio A. Seijas</style></author><author><style face="normal" font="default" size="100%">Tato, Maria Pilar Vazquez</style></author></authors><secondary-authors><author><style face="normal" font="default" size="100%">Seijas, JA</style></author><author><style face="normal" font="default" size="100%">Tato, MPV</style></author><author><style face="normal" font="default" size="100%">Lin, SK</style></author></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Molecular sieves and ultrasound-assisted synthesis of novel 1,3,4-oxadiazole-2-thiones derivatives as potential antifungal agents</style></title><secondary-title><style face="normal" font="default" size="100%">19TH INTERNATIONAL ELECTRONIC CONFERENCE ON SYNTHETIC ORGANIC CHEMISTRY</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">1</style></keyword><keyword><style  face="normal" font="default" size="100%">3</style></keyword><keyword><style  face="normal" font="default" size="100%">4-oxadiazoles</style></keyword><keyword><style  face="normal" font="default" size="100%">Antifungal activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Mannich reaction</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular sieves</style></keyword><keyword><style  face="normal" font="default" size="100%">Ultrasound -assisted</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year></dates><publisher><style face="normal" font="default" size="100%">MDPI; Univ Sanitiago Compostila; SES; Flow Chemistry; REGAL S; Molecules</style></publisher><pub-location><style face="normal" font="default" size="100%">ST. ALBAN-ANLAGE 66, BASEL, CH-4052, SWITZERLAND</style></pub-location><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;In the category of microorganism, fungi are considered as the special class of microbes responsible for opportunistic pathogenic infections in humans species. Due to the side effects of commercially available antifungal drugs and the emergence of new drug resistant fungal species in the past few years, has forced the researchers to search for novel and efficient antifungal drug molecules. The 1,3,4-oxadiazoles scaffold is associated with diverse biological activities. The multipurpose use of the Mannich bases in pharmaceutical chemistry promote us to prepare a new series of 5-(4-(benzyloxy)substituted phenyl)-3-((phenyl amino)methyl)-1,3,4oxadiazole-2(3H)-thione as antifungal agents. Herein, we report molecular sieves and ultrasound assisted synthesis of novel series of Mannich bases of the 5-substituted 1,3,4-oxadiazole-2-thiones by amino methylation with paraformaldehyde and substituted primary / secondary amines and their evaluation for antifungal activity. The structures of the newly synthesized compounds were determined by IR, NMR and Mass spectral study. The synthesized compounds exhibited interesting moderate to excellent antifungal activity against Candida albicans (NCIM 3557), Candida albicans(NCIM3471), Candida glabrata(NCIM3237), Cryptococcus neoformans (NCIM 3542), Cryptococcus neoformans(NCIM 3378), Aspergillus fumigates(NCIM 902), Aspergillus niger(NCIM 628) using Flucanazole as a standard reference drug. The synthesised compounds 6d, 6f,6g, 6h and 6j exhibited promising antifungal activity as antifungal agents.&lt;/p&gt;</style></abstract></record></records></xml>