<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Choudhari, Dinkar</style></author><author><style face="normal" font="default" size="100%">Salunke-Gawali, Sunita</style></author><author><style face="normal" font="default" size="100%">Chakravarty, Debamitra</style></author><author><style face="normal" font="default" size="100%">Shaikh, Samir R.</style></author><author><style face="normal" font="default" size="100%">Lande, Dipali N.</style></author><author><style face="normal" font="default" size="100%">Gejji, Shridhar P.</style></author><author><style face="normal" font="default" size="100%">Rao, Pradeep Kumar</style></author><author><style face="normal" font="default" size="100%">Satpute, Surekha</style></author><author><style face="normal" font="default" size="100%">Puranik, Vedavati G.</style></author><author><style face="normal" font="default" size="100%">Gonnade, Rajesh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Synthesis and biological activity of imidazole based 1,4-naphthoquinones</style></title><secondary-title><style face="normal" font="default" size="100%">New Journal of Chemistry</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">MAY </style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">44</style></volume><pages><style face="normal" font="default" size="100%">6889-6901</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Design and development of drugs in multi-drug resistant (MDR) infections have been of growing interest. We report the syntheses, and antibacterial and antifungal activities of imidazole-based 1,4-naphthoquinones (I-1 to I-4; 1-alkyl-2-methyl-1H-naphtho[2,3-d]imidazole-4,9-dione (alkyl = methyl to butyl)) and their precursors (B-3; N-(3-chloro-1,-dioxo-1,4-dihydronaphthalen-2-yl)acetamide) and A-1 to A-4; N-(3-(alkylamino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)acetamide (alkyl = methyl to butyl). Crystal structures of B-3, A-1 to A-3 and I-2 to I-4 were obtained through single crystal X-ray diffraction experiments. Electronic structure and charge distribution have further been characterized with the use of Density Functional Theory. Seven of these derivatives display a broad spectrum of antibacterial activity against few selected bacterial strains (Gram-positive and Gram-negative). As demonstrated MIC values with B-2 and B-3 against bacterial isolates were 8-64 mu g ml(-1) and those against pathogenic yeast, C. albicans, were observed in the range of 128-256 mu g ml(-1). MIC data of these derivatives suggest them to be promising against pathogens.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">17</style></issue><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">&lt;p&gt;Foreign&lt;/p&gt;
</style></custom3><custom4><style face="normal" font="default" size="100%">&lt;p&gt;3.288&lt;/p&gt;
</style></custom4></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Enumula, Sreenivasulu</style></author><author><style face="normal" font="default" size="100%">Shaikh, Javed</style></author><author><style face="normal" font="default" size="100%">Shaikh, Amin</style></author><author><style face="normal" font="default" size="100%">Sheikh, Kounsar N.</style></author><author><style face="normal" font="default" size="100%">Tambe, Pranav</style></author><author><style face="normal" font="default" size="100%">Lande, Dipali N.</style></author><author><style face="normal" font="default" size="100%">Gejji, Shridhar P.</style></author><author><style face="normal" font="default" size="100%">Shaligram, Parth</style></author><author><style face="normal" font="default" size="100%">Gonnade, Rajesh</style></author><author><style face="normal" font="default" size="100%">Bhadbhade, Mohan</style></author><author><style face="normal" font="default" size="100%">Ahmed, Khursheed</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Structural characterisation, anticancer properties, and BSA binding of 2,6-dipyrazinylpyridines: Insights from experiment and theory</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Molecular Structure</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">2</style></keyword><keyword><style  face="normal" font="default" size="100%">6-dipyrazinylpyridines</style></keyword><keyword><style  face="normal" font="default" size="100%">Bovine serum albumin interaction</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity (HCT-116 cells)</style></keyword><keyword><style  face="normal" font="default" size="100%">Density functional theory</style></keyword><keyword><style  face="normal" font="default" size="100%">Halogenated derivatives</style></keyword><keyword><style  face="normal" font="default" size="100%">Single-crystal X-ray diffraction</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2026</style></year><pub-dates><date><style  face="normal" font="default" size="100%">FEB </style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">1351</style></volume><pages><style face="normal" font="default" size="100%">144225</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;
	The phenyl-(2,6-di-2-pyrazinyl)pyridine derivatives (L1, L2) were synthesized using a one-pot Krohnke-type method, starting from 2-acetylpyrazine and substituted benzaldehydes. Their structures were characterized using a combination of spectroscopic (NMR, HRMS) and single-crystal X-ray diffraction techniques, complemented by density functional theory (DFT). Single-crystal X-ray diffraction reveals that L1 crystallizes in the C2/c space group (T = 296 K) with its supramolecular assembly being stabilized by C-H &amp;amp; ctdot;N and pi-pi stacking interactions, whereas L2 facilitates C-H &amp;amp; ctdot;N, N-H &amp;amp; ctdot;pi bifurcated, and pi-pi* interactions. The bio-interaction properties of L1 were studied using fluorescence spectroscopy with bovine serum albumin (BSA) as a model protein. Fluorescence studies demonstrated L1 induces static quenching of BSA, with a binding constant of 5.15 x 104 mol &amp;amp; sdot;dm-3. Synchronous and three-dimensional fluorescence spectra further demonstrated that L1 brings forth significant conformational changes in BSA. The compounds were evaluated for cytotoxicity against the HCT-116 human colorectal cancer cell line.&lt;/p&gt;
</style></abstract><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">&lt;p&gt;
	Foreign&lt;/p&gt;
</style></custom3><custom4><style face="normal" font="default" size="100%">&lt;p&gt;
	4.0&lt;/p&gt;
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