<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nangia, Ashwini Kumar</style></author><author><style face="normal" font="default" size="100%">Battini, Swapna</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Epalrestat-cytosine cocrystal and salt structures: attempt to control E,Z -&gt; Z,Z isomerization</style></title><secondary-title><style face="normal" font="default" size="100%">Crystal Growth &amp; Design</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">MAY</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">3350–3360</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Cocrystallization of the anti-diabetic drug Eparlestat (EPR) with cytosine (CYT) gave EPR‒‒CYT-H+ form I, a salt-cocrystal hybrid structure, salt hydrate (EPR‒‒CYT-H+‒H2O, 1:2:1), and non-stoichiometric solvates of EPR‒‒CYT-H+ with EtOH/n-PrOH included in the rhombohedral symmetry voids, referred to as form II. Desolvation of EPR‒‒CYT-H+ form II solvates resulted in an unsolvated form II of EPR‒‒CYT-H+ which was characterized by DSC, TGA and NMR. The carboxylate•••cytosinium synthon was observed in the salts structure along with the uncommon CYT-H+•••H+-CYT base pairing in the structures of salt-cocrystal hybrid and salt hydrate. The crystalline forms were characterized by spectroscopic (IR, NMR), thermal (DSC, HSM, TGA), powder X-ray diffraction (PXRD) and single crystal X-ray diffraction (SC-XRD) techniques. The intent of using the salt/ salt-cocrystal forms as a means to stop the E,Z  Z,Z isomerization of EPR was not successful in photo-irradiation experiments.</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">Foreign</style></custom3><custom4><style face="normal" font="default" size="100%">4.425</style></custom4></record></records></xml>