<style face="normal" font="default" size="100%">Synthesis of key intermediate for (+)-tofacitinib through CoIII(salen)-catalyzed two stereocentered hydrolytic kinetic resolution of (Â±)-methyl-3-(oxiran-2-yl)butanoate</style>

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<style face="normal" font="default" size="100%">Synthesis of key intermediate for (+)-tofacitinib through CoIII(salen)-catalyzed two stereocentered hydrolytic kinetic resolution of (Â±)-methyl-3-(oxiran-2-yl)butanoate</style>

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<style face="normal" font="default" size="100%">Short enantioselective total synthesis of (+)-tofacitinib</style>