<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paul, Shatabdi</style></author><author><style face="normal" font="default" size="100%">Yadav, Binduma</style></author><author><style face="normal" font="default" size="100%">Patil, Mahesh D.</style></author><author><style face="normal" font="default" size="100%">Pujari, Anil Kumar</style></author><author><style face="normal" font="default" size="100%">Singh, Umesh</style></author><author><style face="normal" font="default" size="100%">Rishi, Vikas</style></author><author><style face="normal" font="default" size="100%">Bhaumik, Jayeeta</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">photoarchitectonic hydrogel for synergistic in vitro chemo–phototherapy of breast cancer</style></title><secondary-title><style face="normal" font="default" size="100%">Materials Advances</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">JAN</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">5</style></volume><pages><style face="normal" font="default" size="100%">1903-1916</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;
	&lt;span style=&quot;color: rgba(0, 0, 0, 0.79); font-family: &amp;quot;Source Sans Pro&amp;quot;, source-sans-pro, museo_sans300, museo-sans, Arial, sans-serif; font-size: 16px;&quot;&gt;Currently, combinatorial therapy has evoked interest in cancer treatment, and may promote achieving a synergistic effect using cancer medicines. Laser-assisted and pH-responsive therapies have attracted significant attention, and their combination leads to high efficiency cancer treatment. Herein, we developed a chemo–phototherapeutic hydrogel comprised of doxorubicin (DOX, a chemotherapeutic drug) and zinc phthalocyanine (ZnPc, a phototherapeutic drug) for combinatorial and synergistic treatment of breast cancer. Firstly, we have developed carbon dots (CDs, size of ∼5 nm) utilizing lignin and folic acid as biocompatible sources. Then doxorubicin was loaded on the surface of the carbon dots&amp;nbsp;&lt;/span&gt;&lt;em style=&quot;color: rgba(0, 0, 0, 0.79); font-family: &amp;quot;Source Sans Pro&amp;quot;, source-sans-pro, museo_sans300, museo-sans, Arial, sans-serif; font-size: 16px;&quot;&gt;via&lt;/em&gt;&lt;span style=&quot;color: rgba(0, 0, 0, 0.79); font-family: &amp;quot;Source Sans Pro&amp;quot;, source-sans-pro, museo_sans300, museo-sans, Arial, sans-serif; font-size: 16px;&quot;&gt;&amp;nbsp;conjugation (DOX@CDs). Later on, zinc phthalocyanine and acrylic acid derivatives were utilized to develop a laser-responsive hydrogel (ZnPc-PP H). Afterward, doxorubicin-conjugated carbon dots were incorporated into the photoarchitectonic hydrogel to develop a chemo–phototherapeutic drug-loaded hydrogel (DOX@CDs–ZnPc-PP H). Subsequently, the&amp;nbsp;&lt;/span&gt;&lt;em style=&quot;color: rgba(0, 0, 0, 0.79); font-family: &amp;quot;Source Sans Pro&amp;quot;, source-sans-pro, museo_sans300, museo-sans, Arial, sans-serif; font-size: 16px;&quot;&gt;in vitro&lt;/em&gt;&lt;span style=&quot;color: rgba(0, 0, 0, 0.79); font-family: &amp;quot;Source Sans Pro&amp;quot;, source-sans-pro, museo_sans300, museo-sans, Arial, sans-serif; font-size: 16px;&quot;&gt;&amp;nbsp;pH-triggering experiments demonstrated that the hydrogel loaded with both DOX and ZnPc could release the drugs in an acidic environment. Interestingly,&amp;nbsp;&lt;/span&gt;&lt;em style=&quot;color: rgba(0, 0, 0, 0.79); font-family: &amp;quot;Source Sans Pro&amp;quot;, source-sans-pro, museo_sans300, museo-sans, Arial, sans-serif; font-size: 16px;&quot;&gt;in vitro&lt;/em&gt;&lt;span style=&quot;color: rgba(0, 0, 0, 0.79); font-family: &amp;quot;Source Sans Pro&amp;quot;, source-sans-pro, museo_sans300, museo-sans, Arial, sans-serif; font-size: 16px;&quot;&gt;&amp;nbsp;assays confirmed that DOX@CDs–ZnPc-PP H could effectively target breast cancer cells (MCF-7). Furthermore, the developed chemo–phototherapeutic hydrogel exhibited non-cytotoxic behavior. Owing to laser assisted reactive oxygen species generation from ZnPc present in the hydrogel, the growth of MCF-7 cells was significantly lowered. In conclusion, all experimental outcomes indicate that the photoarchitectonic hydrogel has the potential to be applied in synergistic chemo- and photodynamic therapy of cancer.&lt;/span&gt;&lt;/p&gt;
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