<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sultanat</style></author><author><style face="normal" font="default" size="100%">Ali, Abad</style></author><author><style face="normal" font="default" size="100%">Asif, Mohd</style></author><author><style face="normal" font="default" size="100%">Rizvi, Asim</style></author><author><style face="normal" font="default" size="100%">Farhan, Mohd</style></author><author><style face="normal" font="default" size="100%">Zaman, Shamsuz</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Discovery of a novel oxadiazine derivative of glucocorticoids endowed with DNA binding activities and molecular docking studies</style></title><secondary-title><style face="normal" font="default" size="100%">Journal of Taibah University for Science</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">APR</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">536-546</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;span class=&quot;hitHilite&quot;&gt;A&lt;/span&gt; series &lt;span class=&quot;hitHilite&quot;&gt;of&lt;/span&gt; new glucocorticoid oxadiazines (4-6) were synthesized by reacting &lt;span class=&quot;hitHilite&quot;&gt;glucocorticoids&lt;/span&gt; (1-&lt;span class=&quot;hitHilite&quot;&gt;3&lt;/span&gt;) &lt;span class=&quot;hitHilite&quot;&gt;with&lt;/span&gt; thiosemicarbazide and its derivatives. &lt;span class=&quot;hitHilite&quot;&gt;The&lt;/span&gt; structural assignment &lt;span class=&quot;hitHilite&quot;&gt;of&lt;/span&gt; products is confirmed &lt;span class=&quot;hitHilite&quot;&gt;on&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; basis &lt;span class=&quot;hitHilite&quot;&gt;of&lt;/span&gt; IR, H-1 NMR, C-13 NMR, MS and analytical data. &lt;span class=&quot;hitHilite&quot;&gt;The&lt;/span&gt; synthesized compounds (4-6) obeyed &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; Lipinski's &quot;Rule &lt;span class=&quot;hitHilite&quot;&gt;of&lt;/span&gt; Five&quot; analysis based &lt;span class=&quot;hitHilite&quot;&gt;on&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;a&lt;/span&gt; computational prediction &lt;span class=&quot;hitHilite&quot;&gt;of&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;molecular&lt;/span&gt; and pharmacokinetic properties. &lt;span class=&quot;hitHilite&quot;&gt;The&lt;/span&gt; interaction &lt;span class=&quot;hitHilite&quot;&gt;studies&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;of&lt;/span&gt; compounds (4-6) &lt;span class=&quot;hitHilite&quot;&gt;with&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;DNA&lt;/span&gt; were carried out by employing single-cell gel electrophoresis (comet assay), UV-vis and fluorescence spectroscopy. Compounds (4-6) were found capable &lt;span class=&quot;hitHilite&quot;&gt;of&lt;/span&gt; cellular &lt;span class=&quot;hitHilite&quot;&gt;DNA&lt;/span&gt; degradation breakage in isolated normal human lymphocytes. Viscometric and steady-state measurements further correlated &lt;span class=&quot;hitHilite&quot;&gt;with&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; comet assay &lt;span class=&quot;hitHilite&quot;&gt;studies&lt;/span&gt;. Hence, it could be suggested that &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; glucocorticoid compounds bearing &lt;span class=&quot;hitHilite&quot;&gt;a&lt;/span&gt; core &lt;span class=&quot;hitHilite&quot;&gt;oxadiazine&lt;/span&gt; scaffold would be &lt;span class=&quot;hitHilite&quot;&gt;a&lt;/span&gt; potent biological agent. &lt;span class=&quot;hitHilite&quot;&gt;Molecular&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;docking&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;studies&lt;/span&gt; further characterize &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; interaction &lt;span class=&quot;hitHilite&quot;&gt;of&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;the&lt;/span&gt; synthesized compounds &lt;span class=&quot;hitHilite&quot;&gt;with&lt;/span&gt; &lt;span class=&quot;hitHilite&quot;&gt;DNA&lt;/span&gt;.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Article</style></work-type><custom3><style face="normal" font="default" size="100%">&lt;p&gt;Foreign&lt;/p&gt;
</style></custom3><custom4><style face="normal" font="default" size="100%">&lt;p&gt;1.640&lt;/p&gt;
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