<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kasture, Sangita M.</style></author><author><style face="normal" font="default" size="100%">Varma, R</style></author><author><style face="normal" font="default" size="100%">Kalkote, Uttam R.</style></author><author><style face="normal" font="default" size="100%">Nene, S</style></author><author><style face="normal" font="default" size="100%">Kulkarni, Bhaskar D.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Novel enzymatic route for kinetic resolution of (+/-)1,4-benzodioxan-2-carboxylic acid</style></title><secondary-title><style face="normal" font="default" size="100%">Biochemical Engineering Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">1</style></keyword><keyword><style  face="normal" font="default" size="100%">4-benzodioxan-2-carboxylate</style></keyword><keyword><style  face="normal" font="default" size="100%">4-benzodioxan-2-carboxylic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">doxazosin</style></keyword><keyword><style  face="normal" font="default" size="100%">enantio selectivity</style></keyword><keyword><style  face="normal" font="default" size="100%">enantiomeric ratio</style></keyword><keyword><style  face="normal" font="default" size="100%">ethyl 1</style></keyword><keyword><style  face="normal" font="default" size="100%">ethyl acetate</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipases</style></keyword><keyword><style  face="normal" font="default" size="100%">transesterfication</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2005</style></year><pub-dates><date><style  face="normal" font="default" size="100%">DEC</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">1</style></number><publisher><style face="normal" font="default" size="100%">ELSEVIER SCIENCE SA</style></publisher><pub-location><style face="normal" font="default" size="100%">PO BOX 564, 1001 LAUSANNE, SWITZERLAND</style></pub-location><volume><style face="normal" font="default" size="100%">27</style></volume><pages><style face="normal" font="default" size="100%">66-71</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">Ethyl 1,4-benzodioxan-2-carboxylate is used as an intermediate compound for the production of drug doxazosin mesylate. The title compound was kinetically resolved to get S-enantiomer of ethyl 1,4-benzodioxan 2-carboxylate in a simple lipase catalyzed transesterificafion reaction. Ethyl acetate was used as reaction medium as well as acyl donor. The influence of the enzyme source and time of reaction on the enantio selectivity of product were studied. Lipase from Candida antartica-B (Novozyme A/S) catalyzed transesterification reaction with good enantio selectivity towards S-enantiomer. The high enantiomeric ratio, E= 160, provided S-2 an acceptable chemical yield (50%) and enaritiomeric excess (&gt;95%). (c) 2005 Elsevier B.V. All rights reserved.</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><custom3><style face="normal" font="default" size="100%">&lt;p&gt;Foreign&lt;/p&gt;</style></custom3><custom4><style face="normal" font="default" size="100%">2.463</style></custom4></record></records></xml>