01985nas a2200301   4500008004100000022001400041245011300055210006900168260006700237300001200304490000700316520091400323653001601237653003001253653001601283100002601299700002401325700002801349700002801377700001801405700002001423700002301443700002401466700002001490700002201510700002101532856013001553       2015                        eng d  a1744-309100aIron superoxide dismutases in eukaryotic pathogens: new insights from apicomplexa and trypanosoma structures0 aIron superoxide dismutases in eukaryotic pathogens new insights   a111 RIVER ST, HOBOKEN 07030-5774, NJ USAbWILEY-BLACKWELLcMAY  a615-6210 v713 a<p>Prior studies have highlighted the potential of superoxide dismutases as drug targets in eukaryotic pathogens. This report presents the structures of three iron-dependent superoxide dismutases (FeSODs) from Trypanosoma cruzi, Leishmania major and Babesia bovis. Comparison with existing structures from Plasmodium and other trypanosome isoforms shows a very conserved overall fold with subtle differences. In particular, structural data suggest that B. bovis FeSOD may display similar resistance to peroxynitrite-mediated inactivation via an intramolecular electron-transfer pathway as previously described in T. cruzi FeSOD isoform B, thus providing valuable information for structure-based drug design. Furthermore, lysine-acetylation results in T. cruzi indicate that acetylation occurs at a position close to that responsible for the regulation of acetylation-mediated activity in the human enzyme.</p>10aApicomplexa10airon superoxide dismutase10aTrypanosoma1 aPhan, Isabelle, Q. H.1 aDavies, Douglas, R.1 aMoretti, Nilmar, Silvio1 aShanmugam, Dhanasekaran1 aCestari, Igor1 aAnupama, Atashi1 aFairman, James, W.1 aEdwards, Thomas, E.1 aStuart, Kenneth1 aSchenkman, Sergio1 aMyler, Peter, J.  uhttps://library.ncl.res.in/content/iron-superoxide-dismutases-eukaryotic-pathogens-new-insights-apicomplexa-and-trypanosoma-001129nas a2200241   4500008004100000022001400041245007400055210006900129260000900198300001400207490000900221520036100230653001800591653001500609653002300624653001600647100002700663700002300690700001900713700002800732700002100760856010600781       2021                        eng d  a1434-193X00aSynthesis and biological evaluation of hoshionolactam-based compounds0 aSynthesis and biological evaluation of hoshionolactambased compo  cAPR   a2212-22180 v20213 aIn search of novel antitrypanosomal agents based on hoshinolactam (IC50=3.9 nM), we disclose the synthesis and biological evaluations of 14 different analogues of the natural product using combinations of different acids and lactams. Antitrypanosomal activity assays revealed that the synthesized analogues were less potent than the parent natural product.10aHoshinolactam10aOzonolysis10aParasitic diseases10aTrypanosoma1 aJachak, Gorakhnath, R.1 aElizebath, Drishya1 aShukla, Anurag1 aShanmugam, Dhanasekaran1 aReddy, Srinivasa  uhttps://library.ncl.res.in/content/synthesis-and-biological-evaluation-hoshionolactam-based-compounds