01363nas a2200241 4500008004100000022001400041245011400055210006900169260000800238520051600246653002700762653001900789653001900808653001500827653002600842100002700868700002200895700001500917700001800932700002200950700002100972856012800993 2019 eng d a1861-472800aOrtho-oxygenative 1,2-difunctionalization of diarylalkynes under merged gold/organophotoredox relay catalysis0 aOrthooxygenative 12difunctionalization of diarylalkynes under me cOCT3 a

Reported herein is an ortho-oxygenative 1,2-difunctionalization of diarylalkynes under merged gold/organophotoredox catalysis to access highly functionalized 2-(2-hydroxyaryl)-2-alkoxy-1-arylethan-1-ones. Detailed mechanistic studies suggested a relay process, initiating with gold-catalyzed hydroalkoxylation of alkynes, to generate enol-ether followed by a key formal [4+2]-cycloaddition reaction. The successful application of the present methodology was also shown for the synthesis of benzofurans.

10abinary catalyst system10aGold catalysis10aorganocatalyst10aphotoredox10asynthetic methodology1 aSancheti, Shashank, P.1 aAkram, Manjur, O.1 aRoy, Rupam1 aBedi, Vaibhav1 aKundu, Shubhankar1 aPatil, Nitin, T. uhttps://library.ncl.res.in/content/ortho-oxygenative-12-difunctionalization-diarylalkynes-under-merged-goldorganophotoredox01470nas a2200229 4500008004100000022001400041245009300055210006900148260000900217300000700226490000800233520072600241653001100967653001900978653002800997653002401025653001501049653001901064100001601083700002001099856012101119 2026 eng d a0974-362600aPhosphine radical cation catalysis for Markovnikov hydroamination of unactivated alkenes0 aPhosphine radical cation catalysis for Markovnikov hydroaminatio cAPR  a510 v1383 a

Markovnikov-selective hydroamination of unactivated terminal alkenes has long remained a challenging transformation in C-N bond formation. Fan and co-workers1 addressed this using a metal-free phosphine photoredox system that operates via an unprecedented phosphine radical cation (P(IV)) mechanism, enabling alkene activation toward azole addition. This work highlights a powerful new strategy for C(sp3)-N bond construction beyond traditional transition-metal catalysis.Graphical abstractMetal-free phosphine photoredox catalysis enables Markovnikov-selective hydroamination of unactivated terminalalkenes via a novel phosphine radical cation mechanism, off ering a new strategy for C(sp3)-N bond formation.

10aazoles10ahydroamination10aMarkovnikov selectivity10aPhosphine catalysis10aphotoredox10aradical cation1 aDas, Nirmal1 aBarsu, Nagaraju uhttps://library.ncl.res.in/content/phosphine-radical-cation-catalysis-markovnikov-hydroamination-unactivated-alkenes